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A0KSN0 (FTHS_SHESA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Shewana3_0560
OrganismShewanella sp. (strain ANA-3) [Complete proteome] [HAMAP]
Taxonomic identifier94122 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length570 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 570570Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000300538

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A0KSN0 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: E48879BB808BCCBA

FASTA57059,643
        10         20         30         40         50         60 
MLTDMDISRR AHLKDIAALG AEFGLLPDEM QLFGKTKAKV DLRAQQRLAE QQQGKLIIVT 

        70         80         90        100        110        120 
AVTPTPHGEG KTVTTIGLTQ SLKALGNKVC ACIRQPSMGP VFGVKGGAAG GGYAQVVPMQ 

       130        140        150        160        170        180 
ELNLHLTGDI HAVSSAHNLG AAAIASRLYH ETRLGKAEFE SQSGQNYLDI APNGIRWHRV 

       190        200        210        220        230        240 
VDHNDRCLRE IEVGLGENNG PAYTSGFDIT AASELMAILA LSRNLADMRA RIGKLVLAVN 

       250        260        270        280        290        300 
RQGAAISAED LGVAGAMTAI MADAVKPTLM QTLNGAPCLI HAGPFANIAH GNSSVIADDI 

       310        320        330        340        350        360 
ALKLADFVVT EGGFGSDMGF EKFCNIKARQ SGLAPSAAVL VTTLKALKAN SGLTSDADIN 

       370        380        390        400        410        420 
APDQARLEAG FANLNWHINN VARYGIPVVV AINRFATDTD AELNWLIEAV AGTAAFGCEL 

       430        440        450        460        470        480 
SEAFSQGEAG ALTLAQTVMR ACEQPSEFTL LYPDEMALEA KLSTLAEVGY GATGVSLSEA 

       490        500        510        520        530        540 
AKLQLQELSA LGYADLPVCM AKTPLSISHD PQLKGVPQGF IVPVRELVLN AGAGFITALV 

       550        560        570 
GNVMTMPGLG LVPGYLKVDI GADGEITGLG 

« Hide

References

[1]"Complete sequence of chromosome 1 of Shewanella sp. ANA-3."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Newman D., Salticov C., Konstantinidis K., Klappenback J., Tiedje J., Richardson P.
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ANA-3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000469 Genomic DNA. Translation: ABK46799.1.
RefSeqYP_868205.1. NC_008577.1.

3D structure databases

ProteinModelPortalA0KSN0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING94122.Shewana3_0560.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK46799; ABK46799; Shewana3_0560.
GeneID4476521.
KEGGshn:Shewana3_0560.
PATRIC23568704. VBISheSp134792_0812.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.
ProtClustDBPRK13506.

Enzyme and pathway databases

BioCycSSP94122:GJ9K-581-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_SHESA
AccessionPrimary (citable) accession number: A0KSN0
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 12, 2006
Last modified: April 16, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways