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A0KSN0

- FTHS_SHESA

UniProt

A0KSN0 - FTHS_SHESA

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Shewanella sp. (strain ANA-3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSSP94122:GJ9K-581-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Shewana3_0560
    OrganismiShewanella sp. (strain ANA-3)
    Taxonomic identifieri94122 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000002589: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 570570Formate--tetrahydrofolate ligasePRO_0000300538Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi94122.Shewana3_0560.

    Structurei

    3D structure databases

    ProteinModelPortaliA0KSN0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0KSN0-1 [UniParc]FASTAAdd to Basket

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    MLTDMDISRR AHLKDIAALG AEFGLLPDEM QLFGKTKAKV DLRAQQRLAE    50
    QQQGKLIIVT AVTPTPHGEG KTVTTIGLTQ SLKALGNKVC ACIRQPSMGP 100
    VFGVKGGAAG GGYAQVVPMQ ELNLHLTGDI HAVSSAHNLG AAAIASRLYH 150
    ETRLGKAEFE SQSGQNYLDI APNGIRWHRV VDHNDRCLRE IEVGLGENNG 200
    PAYTSGFDIT AASELMAILA LSRNLADMRA RIGKLVLAVN RQGAAISAED 250
    LGVAGAMTAI MADAVKPTLM QTLNGAPCLI HAGPFANIAH GNSSVIADDI 300
    ALKLADFVVT EGGFGSDMGF EKFCNIKARQ SGLAPSAAVL VTTLKALKAN 350
    SGLTSDADIN APDQARLEAG FANLNWHINN VARYGIPVVV AINRFATDTD 400
    AELNWLIEAV AGTAAFGCEL SEAFSQGEAG ALTLAQTVMR ACEQPSEFTL 450
    LYPDEMALEA KLSTLAEVGY GATGVSLSEA AKLQLQELSA LGYADLPVCM 500
    AKTPLSISHD PQLKGVPQGF IVPVRELVLN AGAGFITALV GNVMTMPGLG 550
    LVPGYLKVDI GADGEITGLG 570
    Length:570
    Mass (Da):59,643
    Last modified:December 12, 2006 - v1
    Checksum:iE48879BB808BCCBA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000469 Genomic DNA. Translation: ABK46799.1.
    RefSeqiWP_011715760.1. NC_008577.1.
    YP_868205.1. NC_008577.1.

    Genome annotation databases

    EnsemblBacteriaiABK46799; ABK46799; Shewana3_0560.
    GeneIDi4476521.
    KEGGishn:Shewana3_0560.
    PATRICi23568704. VBISheSp134792_0812.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000469 Genomic DNA. Translation: ABK46799.1 .
    RefSeqi WP_011715760.1. NC_008577.1.
    YP_868205.1. NC_008577.1.

    3D structure databases

    ProteinModelPortali A0KSN0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 94122.Shewana3_0560.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK46799 ; ABK46799 ; Shewana3_0560 .
    GeneIDi 4476521.
    KEGGi shn:Shewana3_0560.
    PATRICi 23568704. VBISheSp134792_0812.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci SSP94122:GJ9K-581-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ANA-3.

    Entry informationi

    Entry nameiFTHS_SHESA
    AccessioniPrimary (citable) accession number: A0KSN0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3