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A0KSN0

- FTHS_SHESA

UniProt

A0KSN0 - FTHS_SHESA

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Shewanella sp. (strain ANA-3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSP94122:GJ9K-581-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Shewana3_0560
OrganismiShewanella sp. (strain ANA-3)
Taxonomic identifieri94122 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002589: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570Formate--tetrahydrofolate ligasePRO_0000300538Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi94122.Shewana3_0560.

Structurei

3D structure databases

ProteinModelPortaliA0KSN0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0KSN0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLTDMDISRR AHLKDIAALG AEFGLLPDEM QLFGKTKAKV DLRAQQRLAE
60 70 80 90 100
QQQGKLIIVT AVTPTPHGEG KTVTTIGLTQ SLKALGNKVC ACIRQPSMGP
110 120 130 140 150
VFGVKGGAAG GGYAQVVPMQ ELNLHLTGDI HAVSSAHNLG AAAIASRLYH
160 170 180 190 200
ETRLGKAEFE SQSGQNYLDI APNGIRWHRV VDHNDRCLRE IEVGLGENNG
210 220 230 240 250
PAYTSGFDIT AASELMAILA LSRNLADMRA RIGKLVLAVN RQGAAISAED
260 270 280 290 300
LGVAGAMTAI MADAVKPTLM QTLNGAPCLI HAGPFANIAH GNSSVIADDI
310 320 330 340 350
ALKLADFVVT EGGFGSDMGF EKFCNIKARQ SGLAPSAAVL VTTLKALKAN
360 370 380 390 400
SGLTSDADIN APDQARLEAG FANLNWHINN VARYGIPVVV AINRFATDTD
410 420 430 440 450
AELNWLIEAV AGTAAFGCEL SEAFSQGEAG ALTLAQTVMR ACEQPSEFTL
460 470 480 490 500
LYPDEMALEA KLSTLAEVGY GATGVSLSEA AKLQLQELSA LGYADLPVCM
510 520 530 540 550
AKTPLSISHD PQLKGVPQGF IVPVRELVLN AGAGFITALV GNVMTMPGLG
560 570
LVPGYLKVDI GADGEITGLG
Length:570
Mass (Da):59,643
Last modified:December 12, 2006 - v1
Checksum:iE48879BB808BCCBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000469 Genomic DNA. Translation: ABK46799.1.
RefSeqiWP_011715760.1. NC_008577.1.
YP_868205.1. NC_008577.1.

Genome annotation databases

EnsemblBacteriaiABK46799; ABK46799; Shewana3_0560.
GeneIDi4476521.
KEGGishn:Shewana3_0560.
PATRICi23568704. VBISheSp134792_0812.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000469 Genomic DNA. Translation: ABK46799.1 .
RefSeqi WP_011715760.1. NC_008577.1.
YP_868205.1. NC_008577.1.

3D structure databases

ProteinModelPortali A0KSN0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 94122.Shewana3_0560.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK46799 ; ABK46799 ; Shewana3_0560 .
GeneIDi 4476521.
KEGGi shn:Shewana3_0560.
PATRICi 23568704. VBISheSp134792_0812.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SSP94122:GJ9K-581-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ANA-3.

Entry informationi

Entry nameiFTHS_SHESA
AccessioniPrimary (citable) accession number: A0KSN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 12, 2006
Last modified: October 1, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3