Reviewed, UniProtKB/Swiss-Prot A0KQG4 (OTC_AERHH)

Names and origin

Protein names

Recommended name:
    Ornithine carbamoyltransferase
      Short name=OTCase
    EC=2.1.3.3

Gene names

Name:	argF
Ordered Locus Names:	AHA_4091

Organism

Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) [Complete proteome] [HAMAP]

Taxonomic identifier

380703 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3. HAMAP MF_01109
Subcellular location	Cytoplasm Probable HAMAP MF_01109.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 334	334	Ornithine carbamoyltransferase HAMAP MF_01109		PRO_1000065071
Regions
	Region	57 – 61	5	Carbamoyl phosphate binding By similarity
	Region	274 – 277	4	Ornithine binding By similarity
Sites
	Binding site	108	1	Carbamoyl phosphate By similarity
	Binding site	135	1	Carbamoyl phosphate By similarity
	Site	32	1	Important for structural integrity By similarity
	Site	148	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0KQG4-1 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 11E93FB5B4BD64FD	FASTA	334	37,596
	10 20 30 40 50 60 MAFNLRNRNF LKLLDFTPRE IQYMIDLAID LKKAKYGGYE RKHLTGKNIA LIFEKTSTRT 70 80 90 100 110 120 RCAFEVAAFD QGAQVSYLGP SGSQIGHKES MKDTARVLGR MYDGIEYRGY GQEIVEELGA 130 140 150 160 170 180 YAGVPVWNGL TNEFHPTQIL ADFMTMLEHG KGKRLDQIKF AYLGDARNNM GNSLMVGAAK 190 200 210 220 230 240 MGMDIRLVAP KAFWPEEDLV AKCRLIAEET GARITLTEDV KEGVLGADFL YTDVWVSMGE 250 260 270 280 290 300 AKEAWDQRVK LMTPYQVNMD VINATKNPDV KFMHCLPAFH NDETTMGKEV ADKYGMKGLE 310 320 330 VTEDVFESEH SIVFDEAENR MHTIKAVMVA TLGD

References

[1]

"Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades." Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.H., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F. J. Bacteriol. 188:8272-8282(2006) [PubMed: 16980456] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000462 Genomic DNA. Translation: ABK38970.1.
RefSeq	YP_858515.1.
3D structure databases
SMR	A0KQG4. Positions 2-334.
ModBase	Search...
Protein-protein interaction databases
STRING	A0KQG4.
Genome annotation databases
GeneID	4490233.
GenomeReviews	Gene locus AHA_4091 in contig CP000462_GR.
KEGG	aha:AHA_4091.
TIGR	AHA_4091.
Phylogenomic databases
eggNOG	COG0078.
HOGENOM	HBG579429.
OMA	GIEYRGY.
PhylomeDB	A0KQG4.
Family and domain databases
HAMAP	MF_01109. OTCase. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002292. Orn_carbamltrans. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
TIGRFAMs	TIGR00658. orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTC_AERHH

Accession

Primary (citable) accession number: A0KQG4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	December 12, 2006
Last modified:	February 9, 2010
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)