ID   PYRB_AERHH              Reviewed;         306 AA.
AC   A0KQG0;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   03-MAR-2009, entry version 17.
DE   RecName: Full=Aspartate carbamoyltransferase;
DE            EC=2.1.3.2;
DE   AltName: Full=Aspartate transcarbamylase;
DE            Short=ATCase;
GN   Name=pyrB; OrderedLocusNames=AHA_4087;
OS   Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=380703;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16980456; DOI=10.1128/JB.00621-06;
RA   Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J.,
RA   Haft D.H., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M.,
RA   Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
RT   "Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all
RT   trades.";
RL   J. Bacteriol. 188:8272-8282(2006).
CC   -!- CATALYTIC ACTIVITY: Carbamoyl phosphate + L-aspartate = phosphate
CC       + N-carbamoyl-L-aspartate.
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo
CC       pathway; UMP from HCO(3)(-): step 2/6.
CC   -!- SIMILARITY: Belongs to the ATCase/OTCase family.
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DR   EMBL; CP000462; ABK38315.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; YP_858511.1; -.
DR   SMR; A0KQG0; 6-309.
DR   GeneID; 4490229; -.
DR   GenomeReviews; CP000462_GR; AHA_4087.
DR   KEGG; aha:AHA_4087; -.
DR   TIGR; AHA_4087; -.
DR   GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR   GO; GO:0004070; F:aspartate carbamoyltransferase activity; IEA:HAMAP.
DR   GO; GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.
DR   GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR   GO; GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00001; -; 1.
DR   InterPro; IPR006132; Asp/Orn_carbamoyltranf_P_bd.
DR   InterPro; IPR006130; Asp/Orn_carbamoylTrfase.
DR   InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn_bd.
DR   InterPro; IPR002082; Aspartate_carbamoyltransf_euk.
DR   Pfam; PF00185; OTCace; 1.
DR   Pfam; PF02729; OTCace_N; 1.
DR   PRINTS; PR00100; AOTCASE.
DR   PRINTS; PR00101; ATCASE.
DR   TIGRFAMs; TIGR00670; asp_carb_tr; 1.
DR   PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Pyrimidine biosynthesis; Transferase.
FT   CHAIN         1    306       Aspartate carbamoyltransferase.
FT                                /FTId=PRO_0000321064.
SQ   SEQUENCE   306 AA;  34084 MW;  5F595B72140AA2BF CRC64;
     MTNPLYKKHV ISISDLTRPD MELVVATAQR LKAEPDTRLL KDKLVASCFF EASTRTRLSF
     ETAVQRLGGN IIGFADGGNT SAKKGETLAD SIKIIGSYTD AVVMRHPKEG AARLASEFSR
     VPVINGGDGS NQHPTQTLLD LFSIHETQGK LDGLNVAFVG DLKYGRTVHS LAQALSLFNC
     RFFFISPEAL AMPDYICEEL EEKGIQFSVH ETMEEVMPEL DILYMTRVQK ERFDETEYKH
     MAAKFVLEVA TLEGAKPTMK ILHPLPRVDE IDVAVDKTPH AYYFQQAENG VYARQALLAL
     VLNETV
//