Reviewed, UniProtKB/Swiss-Prot A0KQG0 (PYRB_AERHH)

Names and origin

Protein names

Recommended name:
    Aspartate carbamoyltransferase
    EC=2.1.3.2
Alternative name(s):
    Aspartate transcarbamylase
      Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	AHA_4087

Organism

Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) [Complete proteome] [HAMAP]

Taxonomic identifier

380703 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length	306 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 2/6. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 306	306	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000321064

Sequences

	Sequence		Length	Mass (Da)
	A0KQG0-1 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: 5F595B72140AA2BF	FASTA	306	34,084
	10 20 30 40 50 60 MTNPLYKKHV ISISDLTRPD MELVVATAQR LKAEPDTRLL KDKLVASCFF EASTRTRLSF 70 80 90 100 110 120 ETAVQRLGGN IIGFADGGNT SAKKGETLAD SIKIIGSYTD AVVMRHPKEG AARLASEFSR 130 140 150 160 170 180 VPVINGGDGS NQHPTQTLLD LFSIHETQGK LDGLNVAFVG DLKYGRTVHS LAQALSLFNC 190 200 210 220 230 240 RFFFISPEAL AMPDYICEEL EEKGIQFSVH ETMEEVMPEL DILYMTRVQK ERFDETEYKH 250 260 270 280 290 300 MAAKFVLEVA TLEGAKPTMK ILHPLPRVDE IDVAVDKTPH AYYFQQAENG VYARQALLAL VLNETV

References

[1]

"Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades." Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.H., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F. J. Bacteriol. 188:8272-8282(2006) [PubMed: 16980456] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000462 Genomic DNA. Translation: ABK38315.1. Different initiation.
RefSeq	YP_858511.1.
3D structure databases
SMR	A0KQG0. Positions 6-309.
ModBase	Search...
Genome annotation databases
GeneID	4490229.
GenomeReviews	Gene locus AHA_4087 in contig CP000462_GR.
KEGG	aha:AHA_4087.
TIGR	AHA_4087.
Family and domain databases
HAMAP	MF_00001. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002082. Aspartate_carbamoyltransf_euk. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
TIGRFAMs	TIGR00670. asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_AERHH

Accession

Primary (citable) accession number: A0KQG0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	March 3, 2009
This is version 17 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)