Reviewed, UniProtKB/Swiss-Prot A0KPE4 (DEOC_AERHH)

Names and origin

Protein names

Recommended name:
    Deoxyribose-phosphate aldolase
    EC=4.1.2.4
Alternative name(s):
    Phosphodeoxyriboaldolase
      Short name=Deoxyriboaldolase
      Short name=DERA

Gene names

Name:	deoC
Ordered Locus Names:	AHA_3690

Organism

Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) [Complete proteome] [HAMAP]

Taxonomic identifier

380703 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP MF_00592
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose 1-phosphate: step 2/2. HAMAP MF_00592
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the deoC/fbaB aldolase family. DeoC type 2 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate catabolic process Inferred from electronic annotation. Source: HAMAP deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 257	257	Deoxyribose-phosphate aldolase HAMAP MF_00592		PRO_1000072592
Sites
	Active site	166	1	Schiff-base intermediate with acetaldehyde By similarity
	Active site	198	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0KPE4-1 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 110C82AD8682F609	FASTA	257	27,359
	10 20 30 40 50 60 MTDLKLAAQR ALNLMDLTTL NDDDTDQKVI DLCRKAKSPA GLTAAVCIYP RFIPIARKTL 70 80 90 100 110 120 REIGAADVRI ATVTNFPHGN DDIEIAVAET RAAVAYGADE VDVVFPYRAF MAGNEQVGFD 130 140 150 160 170 180 LVKACKEACG SQALLKVIIE TGELKEEALI RRASEISIDA GADFIKTSTG KVPVNATPEA 190 200 210 220 230 240 ARIMMEVIKA KNPKVGFKPA GGVKDAAVAG QYLAMAEEIL GKDWVSARTF RFGASSLLAS 250 LLATLGHGDK PANTSGY

References

[1]

"Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades." Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.H., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F. J. Bacteriol. 188:8272-8282(2006) [PubMed: 16980456] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000462 Genomic DNA. Translation: ABK36815.1.
RefSeq	YP_858145.1.
3D structure databases
SMR	A0KPE4. Positions 1-248.
ModBase	Search...
Genome annotation databases
GeneID	4488016.
GenomeReviews	Gene locus AHA_3690 in contig CP000462_GR.
KEGG	aha:AHA_3690.
TIGR	AHA_3690.
Phylogenomic databases
OMA	A0KPE4. CKEACGD.
Family and domain databases
HAMAP	MF_00592. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/AroFGH_arch. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR10889. DeoC. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. deoC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DEOC_AERHH

Accession

Primary (citable) accession number: A0KPE4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	December 12, 2006
Last modified:	June 16, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)