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Protein

tRNA1(Val) (adenine(37)-N6)-methyltransferase

Gene

AHA_3669

Organism
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Specifically methylates the adenine in position 37 of tRNA1(Val) (anticodon cmo5UAC).UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + adenine(37) in tRNA1(Val) = S-adenosyl-L-homocysteine + N(6)-methyladenine(37) in tRNA1(Val).UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA1(Val) (adenine(37)-N6)-methyltransferaseUniRule annotation (EC:2.1.1.223UniRule annotation)
Alternative name(s):
tRNA m6A37 methyltransferaseUniRule annotation
Gene namesi
Ordered Locus Names:AHA_3669
OrganismiAeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240)
Taxonomic identifieri380703 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas
Proteomesi
  • UP000000756 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003873361 – 236tRNA1(Val) (adenine(37)-N6)-methyltransferaseAdd BLAST236

Interactioni

Protein-protein interaction databases

STRINGi380703.AHA_3669.

Structurei

3D structure databases

ProteinModelPortaliA0KPC4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107S47. Bacteria.
COG4123. LUCA.
HOGENOMiHOG000283147.
KOiK15460.
OMAiCQPFYLK.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01872. tRNA_methyltr_YfiC. 1 hit.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR029063. SAM-dependent_MTases.
IPR007848. Small_mtfrase_dom.
IPR022882. tRNA_adenine-N6_MeTrfase.
[Graphical view]
PfamiPF05175. MTS. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0KPC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRNSGFTFK QFHVDHDRCA MKVGTDGILL GAWAPVTNAR RVLDIGSGSG
60 70 80 90 100
LIALMLAQRS PADCRIDAVE LDSNAARQAR ENAAASPWHE RVTVIESAIQ
110 120 130 140 150
TYQATPYDLI VSNPPYFVAG QSFRDPARAL ARHTGGLDSR DLLAACDRLL
160 170 180 190 200
APNGEVALVV PTAMADEILC ISADYDLHAV CYTAVITRAG KEANRVLLRL
210 220 230
GRGLNKCEQG EIVIHSADGT YSDRYIQLTS PFYLKM
Length:236
Mass (Da):25,649
Last modified:December 12, 2006 - v1
Checksum:i40EB3978AB345E08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000462 Genomic DNA. Translation: ABK36818.1.
RefSeqiWP_011707393.1. NC_008570.1.
YP_858125.1. NC_008570.1.

Genome annotation databases

EnsemblBacteriaiABK36818; ABK36818; AHA_3669.
GeneIDi4487751.
KEGGiaha:AHA_3669.
PATRICi20784992. VBIAerHyd135212_3645.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000462 Genomic DNA. Translation: ABK36818.1.
RefSeqiWP_011707393.1. NC_008570.1.
YP_858125.1. NC_008570.1.

3D structure databases

ProteinModelPortaliA0KPC4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi380703.AHA_3669.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK36818; ABK36818; AHA_3669.
GeneIDi4487751.
KEGGiaha:AHA_3669.
PATRICi20784992. VBIAerHyd135212_3645.

Phylogenomic databases

eggNOGiENOG4107S47. Bacteria.
COG4123. LUCA.
HOGENOMiHOG000283147.
KOiK15460.
OMAiCQPFYLK.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01872. tRNA_methyltr_YfiC. 1 hit.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR029063. SAM-dependent_MTases.
IPR007848. Small_mtfrase_dom.
IPR022882. tRNA_adenine-N6_MeTrfase.
[Graphical view]
PfamiPF05175. MTS. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRMN6_AERHH
AccessioniPrimary (citable) accession number: A0KPC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: December 12, 2006
Last modified: November 2, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.