A0KNY4 (FIS_AERHH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA-binding protein fis

Gene names

Name:	fis
Ordered Locus Names:	AHA_3511

Organism

Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) [Complete proteome] [HAMAP]

Taxonomic identifier

380703 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas › Aeromonas hydrophila › Aeromonas hydrophila subsp. hydrophila

Protein attributes

Sequence length	98 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters By similarity. HAMAP-Rule MF_00166
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the transcriptional regulatory fis family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	DNA-binding
Molecular function	Activator
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 98	98	DNA-binding protein fis HAMAP-Rule MF_00166		PRO_1000023320
Regions
	DNA binding	74 – 93	20	H-T-H motif By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0KNY4 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 8A92F8A109363408	FASTA	98	11,170
	10 20 30 40 50 60 MFEQTLTSDA LVTTTHNHAA EPTQRPLRDS VQQALRNYLA QLNGQEVIDL YDMVLSEVEA 70 80 90 PMLDVIMQYT RGNQTRAAVM MGINRGTLRK KLKRYGMN

References

[1]

"Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades." Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.H., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F. J. Bacteriol. 188:8272-8282(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 7966 / NCIB 9240.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000462 Genomic DNA. Translation: ABK36227.1.
RefSeq	YP_857985.1. NC_008570.1.
3D structure databases
ProteinModelPortal	A0KNY4.
SMR	A0KNY4. Positions 1-98.
ModBase	Search...
Protein-protein interaction databases
STRING	380703.AHA_3511.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABK36227; ABK36227; AHA_3511.
GeneID	4488487.
KEGG	aha:AHA_3511.
PATRIC	20784664. VBIAerHyd135212_3499.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2901.
HOGENOM	HOG000256331.
KO	K03557.
OMA	HNQTRAA.
ProtClustDB	PRK00430.
Enzyme and pathway databases
BioCyc	AHYD380703:GH2M-3565-MONOMER.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
HAMAP	MF_00166. DNA-binding_Fis.
InterPro	IPR005412. Fis_DNA-bd. IPR009057. Homeodomain-like. IPR002197. HTH_Fis. [Graphical view]
Pfam	PF02954. HTH_8. 1 hit. [Graphical view]
PIRSF	PIRSF002097. DNA-binding_Fis. 1 hit.
PRINTS	PR01591. DNABINDNGFIS. PR01590. HTHFIS.
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FIS_AERHH

Accession

Primary (citable) accession number: A0KNY4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	December 12, 2006
Last modified:	May 1, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program