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A0KNV3 (GLSA_AERHH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glutaminase
EC=3.5.1.2
Gene names
Name:glsA
Ordered Locus Names:AHA_3480
OrganismAeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) [Complete proteome] [HAMAP]
Taxonomic identifier380703 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas ›

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-glutamine + H2O = L-glutamate + NH3. HAMAP-Rule MF_00313

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the glutaminase family.

Sequence caution

The sequence ABK36822.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglutamine metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionglutaminase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 306306Glutaminase HAMAP-Rule MF_00313
PRO_0000336020

Sites

Binding site641Substrate By similarity
Binding site1151Substrate By similarity
Binding site1591Substrate By similarity
Binding site1661Substrate By similarity
Binding site1901Substrate By similarity
Binding site2421Substrate By similarity
Binding site2601Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
A0KNV3 [UniParc].

Last modified May 20, 2008. Version 2.
Checksum: 0E9D5B2C1D0DFB64

FASTA30632,818
        10         20         30         40         50         60 
MVLSSELLTS ILDEVRPLLG QGKVADYIPA LAQVPADRLG IAVCTVEGEL FTAGDASEPF 

        70         80         90        100        110        120 
SIQSISKALS LTLALTLYQE EEIWARVGKE PSGQPFNSLV QLEFEQGIPR NPFINAGALV 

       130        140        150        160        170        180 
VSDLLETRLT APRQRTLELV RRLSGNPAIM ADQVVARSEY QHSARNAAIA YLMKAYGNFE 

       190        200        210        220        230        240 
NEVDKVLQSY FNACAIRMSC VDLARAFIYL ANRGVPLGAT TPLLPARTTK QVNALLATCG 

       250        260        270        280        290        300 
LYDEAGDFAY RVGMPGKSGV GGGIIALIPG ELCVCVWSPE LNKAGNSLAG TAALELLAER 


LGRSIF

« Hide

References

[1]"Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades."
Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.H., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.
J. Bacteriol. 188:8272-8282(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 7966 / NCIB 9240.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000462 Genomic DNA. Translation: ABK36822.1. Different initiation.
RefSeqYP_857954.1. NC_008570.1.

3D structure databases

ProteinModelPortalA0KNV3.
ModBaseSearch...

Protein-protein interaction databases

STRING380703.AHA_3480.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK36822; ABK36822; AHA_3480.
GeneID4487815.
KEGGaha:AHA_3480.
PATRIC20784602. VBIAerHyd135212_3468.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2066.
HOGENOMHOG000216890.
KOK01425.
ProtClustDBPRK00971.

Enzyme and pathway databases

BioCycAHYD380703:GH2M-3534-MONOMER.

Family and domain databases

Gene3D3.40.710.10. 1 hit.
HAMAPMF_00313. Glutaminase.
InterProIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERPTHR12544. PTHR12544. 1 hit.
PfamPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMSSF56601. PBP_transp_fold. 1 hit.
TIGRFAMsTIGR03814. Gln_ase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGLSA_AERHH
AccessionPrimary (citable) accession number: A0KNV3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: May 1, 2013
This is version 40 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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