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A0KN87

- SYL_AERHH

UniProt

A0KN87 - SYL_AERHH

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei622 – 6221ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAHYD380703:GH2M-3246-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:AHA_3247
OrganismiAeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
Taxonomic identifieri380703 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas
ProteomesiUP000000756: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 859859Leucine--tRNA ligasePRO_0000334725Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi380703.AHA_3247.

Structurei

3D structure databases

ProteinModelPortaliA0KN87.
SMRiA0KN87. Positions 228-413.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi619 – 6235"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0KN87-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQEQYVPQSI EPAVQKHWDA KKTFKAVEKV DKEKFYCLSM FPYPSGRLHM
60 70 80 90 100
GHVRNYTIGD VISRYQRLNG KNVLQPIGWD AFGLPAENAA IKNNTAPAPW
110 120 130 140 150
TYENIEYMKN QLKMLGLGYD WDRELATCKP DYYRWEQWFF TKLYEKGLVY
160 170 180 190 200
KKTSSVNWCP NDMTVLANEQ VVDNCCWRCD TPVEQKEIPQ WFIKITDYAE
210 220 230 240 250
ELLNDIDNLE GWPEMVKTMQ RNWIGRSEGV NISFAIEGQT EHLEVYTTRP
260 270 280 290 300
DTFMGVTYVG IAAGHPLALQ AAESNPELAA FIEECKNTKV AEAELATMEK
310 320 330 340 350
KGMATGLYAI HPLDGRKVPV WVANFVLMNY GTGAVMAVPG HDLRDHEFAT
360 370 380 390 400
KYGLEIKPVI KPVDGELPNV IDAAYTDKGV LFNSGEFDGL EFQPAFDAIA
410 420 430 440 450
SKLESLGCGK RTVNFRLRDW GVSRQRYWGA PIPMLTLADG TVVPTPEDQL
460 470 480 490 500
PVLLPEDVVM DGIQSPIKAD AEWAKTTYNG QEAFRETDTF DTFMESSWYY
510 520 530 540 550
ARYCSPDYDK GMLDPAAANH WLPVDQYIGG IEHACMHLLY ARFFHKLLRD
560 570 580 590 600
AGLVNSDEPF KRLLCQGMVL ADAFYYKDEK GGNVWVSPTD VKVERDEKGR
610 620 630 640 650
ITKAVDNEGR EVIHSGMTKM SKSKNNGIDP QLMVERYGAD TVRLFMMFAS
660 670 680 690 700
PAEMTLEWSD SGVEGAQRFL RRLWRITFEH VSAGVAPALN VAALSVDQKA
710 720 730 740 750
VRRELHKTIA KVSDDVGRRQ TFNTAIAAIM ELMNNLAKLG SDEQDRALMQ
760 770 780 790 800
EALEAVVVML YPITPHIGFE LWKMLGKGDD VDHATWPVAD EAAMVETEKL
810 820 830 840 850
VVVQINGKMR GKLTVPAEIS QADVEKLAMA DASVQKFTDG LTVRKVIYVP

GKLLNIVAN
Length:859
Mass (Da):96,865
Last modified:May 20, 2008 - v2
Checksum:i07D0C1F52ABAE7E3
GO

Sequence cautioni

The sequence ABK38227.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000462 Genomic DNA. Translation: ABK38227.1. Different initiation.
RefSeqiYP_857738.1. NC_008570.1.

Genome annotation databases

EnsemblBacteriaiABK38227; ABK38227; AHA_3247.
GeneIDi4490701.
KEGGiaha:AHA_3247.
PATRICi20784116. VBIAerHyd135212_3242.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000462 Genomic DNA. Translation: ABK38227.1 . Different initiation.
RefSeqi YP_857738.1. NC_008570.1.

3D structure databases

ProteinModelPortali A0KN87.
SMRi A0KN87. Positions 228-413.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 380703.AHA_3247.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK38227 ; ABK38227 ; AHA_3247 .
GeneIDi 4490701.
KEGGi aha:AHA_3247.
PATRICi 20784116. VBIAerHyd135212_3242.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci AHYD380703:GH2M-3246-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 7966 / NCIB 9240.

Entry informationi

Entry nameiSYL_AERHH
AccessioniPrimary (citable) accession number: A0KN87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: October 29, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3