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A0KN87

- SYL_AERHH

UniProt

A0KN87 - SYL_AERHH

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Protein
Leucine--tRNA ligase
Gene
leuS, AHA_3247
Organism
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei622 – 6221ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAHYD380703:GH2M-3246-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:AHA_3247
OrganismiAeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
Taxonomic identifieri380703 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas
ProteomesiUP000000756: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 859859Leucine--tRNA ligaseUniRule annotation
PRO_0000334725Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi380703.AHA_3247.

Structurei

3D structure databases

ProteinModelPortaliA0KN87.
SMRiA0KN87. Positions 228-413.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi619 – 6235"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0KN87-1 [UniParc]FASTAAdd to Basket

« Hide

MQEQYVPQSI EPAVQKHWDA KKTFKAVEKV DKEKFYCLSM FPYPSGRLHM    50
GHVRNYTIGD VISRYQRLNG KNVLQPIGWD AFGLPAENAA IKNNTAPAPW 100
TYENIEYMKN QLKMLGLGYD WDRELATCKP DYYRWEQWFF TKLYEKGLVY 150
KKTSSVNWCP NDMTVLANEQ VVDNCCWRCD TPVEQKEIPQ WFIKITDYAE 200
ELLNDIDNLE GWPEMVKTMQ RNWIGRSEGV NISFAIEGQT EHLEVYTTRP 250
DTFMGVTYVG IAAGHPLALQ AAESNPELAA FIEECKNTKV AEAELATMEK 300
KGMATGLYAI HPLDGRKVPV WVANFVLMNY GTGAVMAVPG HDLRDHEFAT 350
KYGLEIKPVI KPVDGELPNV IDAAYTDKGV LFNSGEFDGL EFQPAFDAIA 400
SKLESLGCGK RTVNFRLRDW GVSRQRYWGA PIPMLTLADG TVVPTPEDQL 450
PVLLPEDVVM DGIQSPIKAD AEWAKTTYNG QEAFRETDTF DTFMESSWYY 500
ARYCSPDYDK GMLDPAAANH WLPVDQYIGG IEHACMHLLY ARFFHKLLRD 550
AGLVNSDEPF KRLLCQGMVL ADAFYYKDEK GGNVWVSPTD VKVERDEKGR 600
ITKAVDNEGR EVIHSGMTKM SKSKNNGIDP QLMVERYGAD TVRLFMMFAS 650
PAEMTLEWSD SGVEGAQRFL RRLWRITFEH VSAGVAPALN VAALSVDQKA 700
VRRELHKTIA KVSDDVGRRQ TFNTAIAAIM ELMNNLAKLG SDEQDRALMQ 750
EALEAVVVML YPITPHIGFE LWKMLGKGDD VDHATWPVAD EAAMVETEKL 800
VVVQINGKMR GKLTVPAEIS QADVEKLAMA DASVQKFTDG LTVRKVIYVP 850
GKLLNIVAN 859
Length:859
Mass (Da):96,865
Last modified:May 20, 2008 - v2
Checksum:i07D0C1F52ABAE7E3
GO

Sequence cautioni

The sequence ABK38227.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000462 Genomic DNA. Translation: ABK38227.1. Different initiation.
RefSeqiYP_857738.1. NC_008570.1.

Genome annotation databases

EnsemblBacteriaiABK38227; ABK38227; AHA_3247.
GeneIDi4490701.
KEGGiaha:AHA_3247.
PATRICi20784116. VBIAerHyd135212_3242.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000462 Genomic DNA. Translation: ABK38227.1 . Different initiation.
RefSeqi YP_857738.1. NC_008570.1.

3D structure databases

ProteinModelPortali A0KN87.
SMRi A0KN87. Positions 228-413.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 380703.AHA_3247.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK38227 ; ABK38227 ; AHA_3247 .
GeneIDi 4490701.
KEGGi aha:AHA_3247.
PATRICi 20784116. VBIAerHyd135212_3242.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci AHYD380703:GH2M-3246-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 7966 / NCIB 9240.

Entry informationi

Entry nameiSYL_AERHH
AccessioniPrimary (citable) accession number: A0KN87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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