ID   ASTD_AERHH              Reviewed;         489 AA.
AC   A0KN18;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   16-JUN-2009, entry version 20.
DE   RecName: Full=N-succinylglutamate 5-semialdehyde dehydrogenase;
DE            EC=1.2.1.71;
DE   AltName: Full=Succinylglutamic semialdehyde dehydrogenase;
DE            Short=SGSD;
GN   Name=astD; OrderedLocusNames=AHA_3178;
OS   Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=380703;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16980456; DOI=10.1128/JB.00621-06;
RA   Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J.,
RA   Haft D.H., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M.,
RA   Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
RT   "Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all
RT   trades.";
RL   J. Bacteriol. 188:8272-8282(2006).
CC   -!- FUNCTION: Catalyzes the NAD-dependent reduction of
CC       succinylglutamate semialdehyde into succinylglutamate (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: N-succinyl-L-glutamate 5-semialdehyde + NAD(+)
CC       + H(2)O = N-succinyl-L-glutamate + NADH.
CC   -!- PATHWAY: Amino-acid degradation; L-arginine degradation via AST
CC       pathway; L-glutamate and succinate from L-arginine: step 4/5.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family. AstD
CC       subfamily.
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DR   EMBL; CP000462; ABK37081.1; -; Genomic_DNA.
DR   RefSeq; YP_857669.1; -.
DR   GeneID; 4489334; -.
DR   GenomeReviews; CP000462_GR; AHA_3178.
DR   KEGG; aha:AHA_3178; -.
DR   TIGR; AHA_3178; -.
DR   OMA; A0KN18; IRAHDER.
DR   GO; GO:0043824; F:succinylglutamate-semialdehyde dehydrogenas...; IEA:EC.
DR   GO; GO:0019544; P:arginine catabolic process to glutamate; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_01174; -; 1.
DR   InterPro; IPR016160; Ald_DH_CS.
DR   InterPro; IPR015590; Aldehyde_DH.
DR   InterPro; IPR017649; SuccinylGlu_semiald_DH_AstD.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   TIGRFAMs; TIGR03240; arg_catab_astD; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Arginine metabolism; Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    489       N-succinylglutamate 5-semialdehyde
FT                                dehydrogenase.
FT                                /FTId=PRO_1000065745.
FT   NP_BIND     223    228       NAD (By similarity).
FT   ACT_SITE    246    246       By similarity.
FT   ACT_SITE    280    280       By similarity.
SQ   SEQUENCE   489 AA;  52211 MW;  C3855005FAC3DF84 CRC64;
     MSQLVQFIDG QWLAGAGKPF ESKDPAKNQV IWQGEAASAA QVEAAVKAAR HAFYHWSDLA
     LDYRLAIVRR YADLLGEHKE ALALTIARET GKPLWETRTE VAAMQGKIAI SIRAHDERTG
     TVENPMPGAK AFVRHKPHGV VAVFGPYNFP GHLPNGHIVP ALIAGNTVVF KPSELTPMVA
     EAMLKIWQEA GLPKGVLNLV QGEVDTGKAL AGNPDIDGLF FTGSSRTGHF LHQQFAGQPG
     KILALEMGGN NPLIVKDVSD IDGAVHAIVQ SAFITSGQRC TCSRRLFVER SVQGDALVKR
     LVEVVGQIKV GLYDAAEQPF MGAMISEKAA LGMVEAQANL QRLGGESLLT LTHLEAGTGF
     VSPGIIDVTA VSALPDEEYF GPLLQLIRYD DFDAAIDQGN ATSFGLSAGL LGDSEADWQH
     FFKRIRAGIV NWNKPITGAS SAAPFGGIGA SGNHRASAYY AADYCAYPVA SVEDSKAAMP
     DQLSPGLTF
//