Reviewed, UniProtKB/Swiss-Prot A0KN18 (ASTD_AERHH)

Names and origin

Protein names

Recommended name:
    N-succinylglutamate 5-semialdehyde dehydrogenase
    EC=1.2.1.71
Alternative name(s):
    Succinylglutamic semialdehyde dehydrogenase
      Short name=SGSD

Gene names

Name:	astD
Ordered Locus Names:	AHA_3178

Organism

Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) [Complete proteome] [HAMAP]

Taxonomic identifier

380703 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length	489 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity.
Catalytic activity	N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH. HAMAP MF_01174
Pathway	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. HAMAP MF_01174
Sequence similarities	Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process to glutamate Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	succinylglutamate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 489	489	N-succinylglutamate 5-semialdehyde dehydrogenase HAMAP MF_01174		PRO_1000065745
Regions
	Nucleotide binding	223 – 228	6	NAD By similarity
Sites
	Active site	246	1	By similarity
	Active site	280	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0KN18-1 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: C3855005FAC3DF84	FASTA	489	52,211
	10 20 30 40 50 60 MSQLVQFIDG QWLAGAGKPF ESKDPAKNQV IWQGEAASAA QVEAAVKAAR HAFYHWSDLA 70 80 90 100 110 120 LDYRLAIVRR YADLLGEHKE ALALTIARET GKPLWETRTE VAAMQGKIAI SIRAHDERTG 130 140 150 160 170 180 TVENPMPGAK AFVRHKPHGV VAVFGPYNFP GHLPNGHIVP ALIAGNTVVF KPSELTPMVA 190 200 210 220 230 240 EAMLKIWQEA GLPKGVLNLV QGEVDTGKAL AGNPDIDGLF FTGSSRTGHF LHQQFAGQPG 250 260 270 280 290 300 KILALEMGGN NPLIVKDVSD IDGAVHAIVQ SAFITSGQRC TCSRRLFVER SVQGDALVKR 310 320 330 340 350 360 LVEVVGQIKV GLYDAAEQPF MGAMISEKAA LGMVEAQANL QRLGGESLLT LTHLEAGTGF 370 380 390 400 410 420 VSPGIIDVTA VSALPDEEYF GPLLQLIRYD DFDAAIDQGN ATSFGLSAGL LGDSEADWQH 430 440 450 460 470 480 FFKRIRAGIV NWNKPITGAS SAAPFGGIGA SGNHRASAYY AADYCAYPVA SVEDSKAAMP DQLSPGLTF

References

[1]

"Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades." Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.H., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F. J. Bacteriol. 188:8272-8282(2006) [PubMed: 16980456] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000462 Genomic DNA. Translation: ABK37081.1.
RefSeq	YP_857669.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4489334.
GenomeReviews	Gene locus AHA_3178 in contig CP000462_GR.
KEGG	aha:AHA_3178.
TIGR	AHA_3178.
Phylogenomic databases
OMA	A0KN18. IRAHDER.
Family and domain databases
HAMAP	MF_01174. [Tree]
InterPro	IPR016160. Ald_DH_CS. IPR015590. Aldehyde_DH. IPR017649. SuccinylGlu_semiald_DH_AstD. [Graphical view]
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
TIGRFAMs	TIGR03240. arg_catab_astD. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASTD_AERHH

Accession

Primary (citable) accession number: A0KN18

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	December 12, 2006
Last modified:	June 16, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)