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A0KKQ2 (A0KKQ2_AERHH) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length915 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP-Rule MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP-Rule MF_01897 SAAS SAAS005743

Subunit structure

Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis By similarity. HAMAP-Rule MF_01897

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP-Rule MF_01897

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1221O-(5'-phospho-DNA)-tyrosine intermediate By similarity HAMAP-Rule MF_01897

Sequences

Sequence LengthMass (Da)Tools
A0KKQ2 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 03DBFCC80C3DF193

FASTA915100,484
        10         20         30         40         50         60 
MSDLAREITP VNIEEELKSS YLDYAMSVIV GRALPDVRDG LKPVHRRVLY AMNELGNDWN 

        70         80         90        100        110        120 
KPYKKSARVV GDVIGKYHPH GDSAVYDTIV RMAQDFSMRY MLVDGQGNFG SVDGDSAAAM 

       130        140        150        160        170        180 
RYTEVRMARI SHELLADLDK ETVDWVPNYD GTEMIPAVMP TKVPNLLVNG SSGIAVGMAT 

       190        200        210        220        230        240 
NIPPHNLTEI VNGCLALIEN GDLTIDELMT YITGPDFPTG GIINGRSGIV QAYRTGRGSV 

       250        260        270        280        290        300 
YVRAKAEVEV DEKTSRETII VHEIPYQVNK ARLIEKIAEL VKEKKIEGIS ALRDESDKDG 

       310        320        330        340        350        360 
MRIVIEIKRG ESGEIVLNNL YKHTQMQTTF GINMVALDNN QPKVMNLKEI LDAFLLHRRE 

       370        380        390        400        410        420 
VVTRRTVFEL RKARDRAHIL EGLAVALANI DPVIELIRHS ATPADAKAGL VARGWELGNV 

       430        440        450        460        470        480 
ASMLEKAGDD AARPEWLEPE FGIREGHYYL TEQQAQAILD LRLHKLTGLE HEKILEEYQS 

       490        500        510        520        530        540 
LLDLIAELLF ILASPVRLME VIRDELLAVR EQYGDERRTE ISMSSAEINI EDLITPEDVV 

       550        560        570        580        590        600 
VTLSHQGYVK YQPLSDYEAQ RRGGRGKSAT RIKEEDFVER LLVANTHDTI LCFSTRGKVY 

       610        620        630        640        650        660 
WLKVYQLPEA SRGARGRPII NLLPLDEGER ITAILPVKEY DADKYVFFAT ANGTVKKTSL 

       670        680        690        700        710        720 
SDFSRPLSSG IRAINLKEGD ELIGVDITDG SNEIMLFSDA GKVVRFAEGS GRADADATDE 

       730        740        750        760        770        780 
VDTDDDAGND DDGSDNGEGT ESKGTFKGVR PMGRTAAGVR GIKLGAGDKV VSLIVPRGDG 

       790        800        810        820        830        840 
AILTATENGY GKRTALDEYP TKSRGTQGVI SIKVDERNGK VIDAIQVEDT DQIMLITNGG 

       850        860        870        880        890        900 
TLVRTRVSEV SVIGRNTGGV RLIRTGEDET VVGLQRVAES DEDENEVLAV EGEVSEGTDT 

       910 
AADTGAVDAG EAGDE

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References

[1]"Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades."
Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.H., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.
J. Bacteriol. 188:8272-8282(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 7966 / NCIB 9240.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000462 Genomic DNA. Translation: ABK36039.1.
RefSeqYP_856853.1. NC_008570.1.

3D structure databases

ProteinModelPortalA0KKQ2.
SMRA0KKQ2. Positions 30-522, 535-879.
ModBaseSearch...

Protein-protein interaction databases

STRING380703.AHA_2330.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK36039; ABK36039; AHA_2330.
GeneID4489759.
KEGGaha:AHA_2330.
PATRIC20782234. VBIAerHyd135212_2332.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0188.
HOGENOMHOG000076278.
KOK02469.
OMAIAQEDVV.
ProtClustDBPRK05560.

Enzyme and pathway databases

BioCycAHYD380703:GH2M-2434-MONOMER.

Family and domain databases

Gene3D1.10.268.10. 1 hit.
3.30.1360.40. 1 hit.
3.90.199.10. 1 hit.
HAMAPMF_01897. GyrA.
InterProIPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR013760. Topo_IIA_like_dom.
[Graphical view]
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01063. gyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA0KKQ2_AERHH
AccessionPrimary (citable) accession number: A0KKQ2
Entry history
Integrated into UniProtKB/TrEMBL: December 12, 2006
Last sequence update: December 12, 2006
Last modified: May 1, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info