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Protein

Biosynthetic peptidoglycan transglycosylase

Gene

mtgA

Organism
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.UniRule annotation

Catalytic activityi

(GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n)-diphosphoundecaprenol + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = (GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n+1)-diphosphoundecaprenol + undecaprenyl diphosphate.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciAHYD380703:G1G7B-2129-MONOMER
UniPathwayiUPA00219

Protein family/group databases

CAZyiGT51 Glycosyltransferase Family 51

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic peptidoglycan transglycosylaseUniRule annotation (EC:2.4.1.129UniRule annotation)
Alternative name(s):
Glycan polymeraseUniRule annotation
Peptidoglycan glycosyltransferase MtgAUniRule annotation
Short name:
PGTUniRule annotation
Gene namesi
Name:mtgAUniRule annotation
Ordered Locus Names:AHA_2130
OrganismiAeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240)
Taxonomic identifieri380703 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas
Proteomesi
  • UP000000756 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 34HelicalUniRule annotationAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000172981 – 235Biosynthetic peptidoglycan transglycosylaseAdd BLAST235

Proteomic databases

PRIDEiA0KK53

Interactioni

Protein-protein interaction databases

STRINGi380703.AHA_2130

Structurei

3D structure databases

ProteinModelPortaliA0KK53
SMRiA0KK53
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 51 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108VKV Bacteria
COG0744 LUCA
HOGENOMiHOG000288117
KOiK03814
OMAiPAPKCFD

Family and domain databases

Gene3Di1.10.3810.10, 1 hit
HAMAPiMF_00766 PGT_MtgA, 1 hit
InterProiView protein in InterPro
IPR001264 Glyco_trans_51
IPR023346 Lysozyme-like_dom_sf
IPR036950 PBP_transglycosylase
IPR011812 Pep_trsgly
PANTHERiPTHR30400 PTHR30400, 1 hit
PfamiView protein in Pfam
PF00912 Transgly, 1 hit
SUPFAMiSSF53955 SSF53955, 1 hit
TIGRFAMsiTIGR02070 mono_pep_trsgly, 1 hit

Sequencei

Sequence statusi: Complete.

A0KK53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPALARRLL SGLGKLLLAA LLSTIVSVAL LRFIDPPMWT WRLERALFPP
60 70 80 90 100
AKVAEVKHDW VPLEQISREL QLAVIAAEDQ RFAEHNGFDM DAISSALKHN
110 120 130 140 150
QHSERVRGAS TLSQQTAKNL FMWSDRSFLR KGIEAWFTLL MELGWDKSRI
160 170 180 190 200
LEMYLNIVEF GPGIYGAEAA ARHYFGKPAA RLTRYEASLL AAALPNPWRY
210 220 230
RVKPPSPYVQ QRSAWIRRQM GQLGQITLNK VHQAD
Length:235
Mass (Da):26,801
Last modified:December 12, 2006 - v1
Checksum:iF0F77935E173BE47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000462 Genomic DNA Translation: ABK38359.1
RefSeqiWP_011705989.1, NC_008570.1
YP_856654.1, NC_008570.1

Genome annotation databases

EnsemblBacteriaiABK38359; ABK38359; AHA_2130
GeneIDi4487631
KEGGiaha:AHA_2130
PATRICifig|380703.7.peg.2131

Similar proteinsi

Entry informationi

Entry nameiMTGA_AERHH
AccessioniPrimary (citable) accession number: A0KK53
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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