A0KJU1 (A0KJU1_AERHH) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
ATP-dependent Clp protease proteolytic subunit HAMAP MF_00444 RuleBase RU003567
EC=3.4.21.92 HAMAP MF_00444 RuleBase RU000549

Alternative name(s):
Endopeptidase Clp HAMAP MF_00444

Gene names

Name:	clpP HAMAP MF_00444 EMBL ABK38774.1
Ordered Locus Names:	AHA_2011

Organism

Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) [Complete proteome] [HAMAP]

Taxonomic identifier

380703 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length	200 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity. HAMAP MF_00444 RuleBase RU000550
Catalytic activity	Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs). HAMAP MF_00444 RuleBase RU000549
Subcellular location	Cytoplasm By similarity HAMAP MF_00444.
Sequence similarities	Belongs to the peptidase S14 family. HAMAP MF_00444 RuleBase RU003567

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP MF_00444
Ligand	ATP-binding HAMAP MF_00444 Nucleotide-binding
Molecular function	Hydrolase Protease Serine protease HAMAP MF_00444 RuleBase RU000549
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW serine-type endopeptidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	104	1	By similarity HAMAP MF_00444
	Active site	129	1	By similarity HAMAP MF_00444

Sequences

	Sequence		Length	Mass (Da)
	A0KJU1 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 24E809AF47CAEABA	FASTA	200	21,958
	10 20 30 40 50 60 MTESPRNALI PMVVEQTAKG ERSYDIYSRL LKERVIFLTG QVEDHMANLV VAQLLFLESE 70 80 90 100 110 120 NPDQDISIYI NSPGGAVTAG MSIYDTMQFI KPDVSTVCMG QACSMGAFLL AGGAKGKRFC 130 140 150 160 170 180 LPNARVMIHQ PLGGFQGQAS DIQIHAQEIL KIKNTLNERL AFHTGQDMAT IERDTDRDNF 190 200 MSAEQAVAYG LVDGVLSRRG

References

[1]

"Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades." Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.H., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F. J. Bacteriol. 188:8272-8282(2006) [PubMed: 16980456] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000462 Genomic DNA. Translation: ABK38774.1.
RefSeq	YP_856542.1. NC_008570.1.
3D structure databases
ProteinModelPortal	A0KJU1.
SMR	A0KJU1. Positions 8-199.
ModBase	Search...
Protein-protein interaction databases
STRING	A0KJU1.
Protein family/group databases
MEROPS	S14.001.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4489244.
GenomeReviews	Gene locus AHA_2011 in contig CP000462_GR.
KEGG	aha:AHA_2011.
PATRIC	20781622. VBIAerHyd135212_2032.
TIGR	AHA_2011.
Phylogenomic databases
eggNOG	COG0740.
HOGENOM	HBG558421.
OMA	ELMAKHT.
PhylomeDB	A0KJU1.
ProtClustDB	PRK00277.
Family and domain databases
HAMAP	MF_00444. ClpP. [Tree]
InterPro	IPR023562. Pept_S14/S49. IPR001907. Pept_S14_ClpP. IPR018215. Pept_S14_ClpP_AS. [Graphical view]
KO	K01358.
PANTHER	PTHR10381. Pept_S14_ClpP. 1 hit.
Pfam	PF00574. CLP_protease. 1 hit. [Graphical view]
PRINTS	PR00127. CLPPROTEASEP.
TIGRFAMs	TIGR00493. ClpP. 1 hit.
PROSITE	PS00382. CLP_PROTEASE_HIS. 1 hit. PS00381. CLP_PROTEASE_SER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A0KJU1_AERHH

Accession

Primary (citable) accession number: A0KJU1

Entry history

Integrated into UniProtKB/TrEMBL:	December 12, 2006
Last sequence update:	December 12, 2006
Last modified:	December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)