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A0KJM0 (PHNX_AERHH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphonoacetaldehyde hydrolase

Short name=Phosphonatase
EC=3.11.1.1
Alternative name(s):
Phosphonoacetaldehyde phosphonohydrolase
Gene names
Name:phnX
Ordered Locus Names:AHA_1940
OrganismAeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) [Complete proteome] [HAMAP]
Taxonomic identifier380703 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas

Protein attributes

Sequence length279 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in phosphonate degradation By similarity. HAMAP-Rule MF_01375

Catalytic activity

Phosphonoacetaldehyde + H2O = acetaldehyde + phosphate. HAMAP-Rule MF_01375

Cofactor

Binds 1 Mg2+ ion per subunit By similarity. HAMAP-Rule MF_01375

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01375

Sequence similarities

Belongs to the HAD-like hydrolase superfamily. PhnX family.

Ontologies

Keywords
   LigandMagnesium
Metal-binding
Schiff base
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processorganic phosphonate catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionmagnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

phosphonoacetaldehyde hydrolase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 279279Phosphonoacetaldehyde hydrolase HAMAP-Rule MF_01375
PRO_0000284573

Sites

Active site201Nucleophile By similarity
Active site621Schiff-base intermediate with substrate By similarity
Metal binding201Magnesium By similarity
Metal binding221Magnesium; via carbonyl oxygen By similarity
Metal binding1961Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
A0KJM0 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 5599F76509E3D2AF

FASTA27929,882
        10         20         30         40         50         60 
MTDLQIAVDP TTDVEALILD WAGTVVDFGS FAPTSIFVEA FARAYDFPVT LDEARQPMGL 

        70         80         90        100        110        120 
GKWDHIAALG RLPSVDARWQ ARFGHPMSHA EVDHLYHTFM PLQIAAVTRF ADPIPGVLPV 

       130        140        150        160        170        180 
LDALRGQGMK IGSCSGYPRP VMETLVPAAA DHGYRPDHWV ATDDLKAGGR PGPWMALANV 

       190        200        210        220        230        240 
IELGVNAVHR CIKVDDAVPG ISEGLNAGMW TVGLSVSGNE FGATWEAFAA MSEAEIAARR 

       250        260        270 
APAEAKLRAA GAHYVIDTLA DIAPVIADIN RRLAAGERP 

« Hide

References

[1]"Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades."
Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.H., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.
J. Bacteriol. 188:8272-8282(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 7966 / NCIB 9240.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000462 Genomic DNA. Translation: ABK38391.1.
RefSeqYP_856471.1. NC_008570.1.

3D structure databases

ProteinModelPortalA0KJM0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING380703.AHA_1940.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK38391; ABK38391; AHA_1940.
GeneID4489099.
KEGGaha:AHA_1940.
PATRIC20781468. VBIAerHyd135212_1955.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0637.
HOGENOMHOG000217971.
KOK05306.
OMAFDWAGTM.
OrthoDBEOG6ZH2FH.
ProtClustDBPRK13478.

Enzyme and pathway databases

BioCycAHYD380703:GH2M-1940-MONOMER.

Family and domain databases

Gene3D1.10.150.240. 1 hit.
3.40.50.1000. 2 hits.
HAMAPMF_01375. PhnX.
InterProIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR023198. PGP_dom2.
IPR006323. Phosphonoacetald_hydro.
[Graphical view]
PfamPF13419. HAD_2. 1 hit.
[Graphical view]
SUPFAMSSF56784. SSF56784. 1 hit.
TIGRFAMsTIGR01509. HAD-SF-IA-v3. 1 hit.
TIGR01422. phosphonatase. 1 hit.
ProtoNetSearch...

Entry information

Entry namePHNX_AERHH
AccessionPrimary (citable) accession number: A0KJM0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 12, 2006
Last modified: February 19, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families