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Protein

Phosphonoacetaldehyde hydrolase

Gene

phnX

Organism
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in phosphonate degradation.UniRule annotation

Catalytic activityi

Phosphonoacetaldehyde + H2O = acetaldehyde + phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei20NucleophileUniRule annotation1
Metal bindingi20MagnesiumUniRule annotation1
Metal bindingi22Magnesium; via carbonyl oxygenUniRule annotation1
Active sitei62Schiff-base intermediate with substrateUniRule annotation1
Metal bindingi196MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Metal-binding, Schiff base

Enzyme and pathway databases

BioCyciAHYD380703:G1G7B-1939-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphonoacetaldehyde hydrolaseUniRule annotation (EC:3.11.1.1UniRule annotation)
Short name:
PhosphonataseUniRule annotation
Alternative name(s):
Phosphonoacetaldehyde phosphonohydrolaseUniRule annotation
Gene namesi
Name:phnXUniRule annotation
Ordered Locus Names:AHA_1940
OrganismiAeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240)
Taxonomic identifieri380703 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas
Proteomesi
  • UP000000756 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002845731 – 279Phosphonoacetaldehyde hydrolaseAdd BLAST279

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi380703.AHA_1940

Structurei

3D structure databases

ProteinModelPortaliA0KJM0
SMRiA0KJM0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HAD-like hydrolase superfamily. PhnX family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108KAZ Bacteria
COG0637 LUCA
HOGENOMiHOG000217971
KOiK05306
OMAiKAVIFDW

Family and domain databases

CDDicd02586 HAD_PHN, 1 hit
Gene3Di1.10.150.240, 1 hit
3.40.50.1000, 2 hits
HAMAPiMF_01375 PhnX, 1 hit
InterProiView protein in InterPro
IPR036412 HAD-like_sf
IPR006439 HAD-SF_hydro_IA
IPR023214 HAD_sf
IPR023198 PGP-like_dom2
IPR006323 Phosphonoacetald_hydro
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR01509 HAD-SF-IA-v3, 1 hit
TIGR01422 phosphonatase, 1 hit

Sequencei

Sequence statusi: Complete.

A0KJM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDLQIAVDP TTDVEALILD WAGTVVDFGS FAPTSIFVEA FARAYDFPVT
60 70 80 90 100
LDEARQPMGL GKWDHIAALG RLPSVDARWQ ARFGHPMSHA EVDHLYHTFM
110 120 130 140 150
PLQIAAVTRF ADPIPGVLPV LDALRGQGMK IGSCSGYPRP VMETLVPAAA
160 170 180 190 200
DHGYRPDHWV ATDDLKAGGR PGPWMALANV IELGVNAVHR CIKVDDAVPG
210 220 230 240 250
ISEGLNAGMW TVGLSVSGNE FGATWEAFAA MSEAEIAARR APAEAKLRAA
260 270
GAHYVIDTLA DIAPVIADIN RRLAAGERP
Length:279
Mass (Da):29,882
Last modified:December 12, 2006 - v1
Checksum:i5599F76509E3D2AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000462 Genomic DNA Translation: ABK38391.1
RefSeqiWP_011705810.1, NC_008570.1
YP_856471.1, NC_008570.1

Genome annotation databases

EnsemblBacteriaiABK38391; ABK38391; AHA_1940
GeneIDi4489099
KEGGiaha:AHA_1940
PATRICifig|380703.7.peg.1955

Similar proteinsi

Entry informationi

Entry nameiPHNX_AERHH
AccessioniPrimary (citable) accession number: A0KJM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 12, 2006
Last modified: March 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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