Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A0KJM0

- PHNX_AERHH

UniProt

A0KJM0 - PHNX_AERHH

Protein

Phosphonoacetaldehyde hydrolase

Gene

phnX

Organism
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in phosphonate degradation.UniRule annotation

    Catalytic activityi

    Phosphonoacetaldehyde + H2O = acetaldehyde + phosphate.UniRule annotation

    Cofactori

    Binds 1 Mg2+ ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei20 – 201NucleophileUniRule annotation
    Metal bindingi20 – 201MagnesiumUniRule annotation
    Metal bindingi22 – 221Magnesium; via carbonyl oxygenUniRule annotation
    Active sitei62 – 621Schiff-base intermediate with substrateUniRule annotation
    Metal bindingi196 – 1961MagnesiumUniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. phosphonoacetaldehyde hydrolase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. organic phosphonate catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Magnesium, Metal-binding, Schiff base

    Enzyme and pathway databases

    BioCyciAHYD380703:GH2M-1940-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphonoacetaldehyde hydrolaseUniRule annotation (EC:3.11.1.1UniRule annotation)
    Short name:
    PhosphonataseUniRule annotation
    Alternative name(s):
    Phosphonoacetaldehyde phosphonohydrolaseUniRule annotation
    Gene namesi
    Name:phnXUniRule annotation
    Ordered Locus Names:AHA_1940
    OrganismiAeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
    Taxonomic identifieri380703 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas
    ProteomesiUP000000756: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 279279Phosphonoacetaldehyde hydrolasePRO_0000284573Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi380703.AHA_1940.

    Structurei

    3D structure databases

    ProteinModelPortaliA0KJM0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HAD-like hydrolase superfamily. PhnX family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0637.
    HOGENOMiHOG000217971.
    KOiK05306.
    OMAiGATWEEY.
    OrthoDBiEOG6ZH2FH.

    Family and domain databases

    Gene3Di1.10.150.240. 1 hit.
    3.40.50.1000. 2 hits.
    HAMAPiMF_01375. PhnX.
    InterProiIPR023214. HAD-like_dom.
    IPR006439. HAD-SF_hydro_IA.
    IPR023198. PGP_dom2.
    IPR006323. Phosphonoacetald_hydro.
    [Graphical view]
    PfamiPF13419. HAD_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR01509. HAD-SF-IA-v3. 1 hit.
    TIGR01422. phosphonatase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A0KJM0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDLQIAVDP TTDVEALILD WAGTVVDFGS FAPTSIFVEA FARAYDFPVT    50
    LDEARQPMGL GKWDHIAALG RLPSVDARWQ ARFGHPMSHA EVDHLYHTFM 100
    PLQIAAVTRF ADPIPGVLPV LDALRGQGMK IGSCSGYPRP VMETLVPAAA 150
    DHGYRPDHWV ATDDLKAGGR PGPWMALANV IELGVNAVHR CIKVDDAVPG 200
    ISEGLNAGMW TVGLSVSGNE FGATWEAFAA MSEAEIAARR APAEAKLRAA 250
    GAHYVIDTLA DIAPVIADIN RRLAAGERP 279
    Length:279
    Mass (Da):29,882
    Last modified:December 12, 2006 - v1
    Checksum:i5599F76509E3D2AF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000462 Genomic DNA. Translation: ABK38391.1.
    RefSeqiWP_011705810.1. NC_008570.1.
    YP_856471.1. NC_008570.1.

    Genome annotation databases

    EnsemblBacteriaiABK38391; ABK38391; AHA_1940.
    GeneIDi4489099.
    KEGGiaha:AHA_1940.
    PATRICi20781468. VBIAerHyd135212_1955.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000462 Genomic DNA. Translation: ABK38391.1 .
    RefSeqi WP_011705810.1. NC_008570.1.
    YP_856471.1. NC_008570.1.

    3D structure databases

    ProteinModelPortali A0KJM0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 380703.AHA_1940.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK38391 ; ABK38391 ; AHA_1940 .
    GeneIDi 4489099.
    KEGGi aha:AHA_1940.
    PATRICi 20781468. VBIAerHyd135212_1955.

    Phylogenomic databases

    eggNOGi COG0637.
    HOGENOMi HOG000217971.
    KOi K05306.
    OMAi GATWEEY.
    OrthoDBi EOG6ZH2FH.

    Enzyme and pathway databases

    BioCyci AHYD380703:GH2M-1940-MONOMER.

    Family and domain databases

    Gene3Di 1.10.150.240. 1 hit.
    3.40.50.1000. 2 hits.
    HAMAPi MF_01375. PhnX.
    InterProi IPR023214. HAD-like_dom.
    IPR006439. HAD-SF_hydro_IA.
    IPR023198. PGP_dom2.
    IPR006323. Phosphonoacetald_hydro.
    [Graphical view ]
    Pfami PF13419. HAD_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR01509. HAD-SF-IA-v3. 1 hit.
    TIGR01422. phosphonatase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 7966 / NCIB 9240.

    Entry informationi

    Entry nameiPHNX_AERHH
    AccessioniPrimary (citable) accession number: A0KJM0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 17, 2007
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3