A0KJI0 (ARAA_AERHH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-arabinose isomerase
EC=5.3.1.4

Gene names

Name:	araA
Ordered Locus Names:	AHA_1900

Organism

Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) [Complete proteome] [HAMAP]

Taxonomic identifier

380703 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length	499 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of L-arabinose to L-ribulose By similarity. HAMAP MF_00519
Catalytic activity	L-arabinose = L-ribulose. HAMAP MF_00519
Cofactor	Binds 1 manganese ion per subunit By similarity. HAMAP MF_00519
Pathway	Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3. HAMAP MF_00519
Sequence similarities	Belongs to the arabinose isomerase family.

Ontologies

Keywords
Biological process	Arabinose catabolism Carbohydrate metabolism
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arabinose catabolic process Inferred from electronic annotation. Source: UniProtKB-KW fucose metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	L-arabinose isomerase activity Inferred from electronic annotation. Source: EC L-fucose isomerase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 499	499	L-arabinose isomerase HAMAP MF_00519		PRO_0000312597
Sites
	Metal binding	306	1	Manganese By similarity
	Metal binding	333	1	Manganese By similarity
	Metal binding	350	1	Manganese By similarity
	Metal binding	449	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0KJI0 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 103263E9E9086862	FASTA	499	55,374
	10 20 30 40 50 60 MELMKQLEVW FLVGSQHLYG AATLKQVADH AHTITSQLNE RAGLPVKIVL KPTGTTLDEI 70 80 90 100 110 120 SAIARDANHD QRCIGLMVWM HTFSPAKMWI PALSQLQKPL LQFHTQFNRD LPWSEIDMDF 130 140 150 160 170 180 MNLNQTAHGG REFGFMGARL RLPRTVVVGH WQDEEAHRKL GNWMRVAAAI HDSRHLKIAR 190 200 210 220 230 240 FGDNMRNVAV TEGDKIEAQI QFGYQVNYHP VGDLVKVIDA VPASDIEALL AEYEESYTLT 250 260 270 280 290 300 EAVQAGGVLR ASLYEAARQE LGMKKFLTDG GFGAFTTTFE DLHGLHQLPG LACQRLMQQG 310 320 330 340 350 360 FGFGAEGDWK TAALLRTLKV MGTGLAGGTS FMEDYTYHLE AGNNLVLGAH MLEVCPSIAA 370 380 390 400 410 420 DKPVLDAQHL GIGKKADPAR LLFAAPAGKA VNASLIDLGN RFRLVVNQLE VVDLPEAMPK 430 440 450 460 470 480 LPVASALWQP MPDLQTSAEA WILAGAAHHS VFTQSVDIEQ LRTFADLMGI EFVVIDKHTR 490 IPELKQTLQW NEVYYKLCH

References

[1]

"Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades." Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.H., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F. J. Bacteriol. 188:8272-8282(2006) [PubMed: 16980456] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 7966 / NCIB 9240.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000462 Genomic DNA. Translation: ABK36959.1.
RefSeq	YP_856431.1. NC_008570.1.
3D structure databases
ProteinModelPortal	A0KJI0.
SMR	A0KJI0. Positions 1-495.
ModBase	Search...
Protein-protein interaction databases
STRING	A0KJI0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4488672.
GenomeReviews	Gene locus AHA_1900 in contig CP000462_GR.
KEGG	aha:AHA_1900.
PATRIC	20781384. VBIAerHyd135212_1913.
TIGR	AHA_1900.
Phylogenomic databases
eggNOG	COG2160.
HOGENOM	HBG297198.
OMA	EVCPTIA.
PhylomeDB	A0KJI0.
ProtClustDB	PRK02929.
Enzyme and pathway databases
BioCyc	AHYD196024:AHA_1900-MONOMER.
Family and domain databases
HAMAP	MF_00519. Arabinose_Isome. [Tree]
InterPro	IPR024664. Ara_Isoase_C. IPR004216. Fuc/Ara_isomerase_C. IPR009015. Fucose_isomerase_N/cen. IPR003762. Lara_isomerase. [Graphical view]
KO	K01804.
Pfam	PF11762. Arabinose_Iso_C. 1 hit. PF02610. Arabinose_Isome. 1 hit. [Graphical view]
PIRSF	PIRSF001478. L-ara_isomerase. 1 hit.
ProDom	PD018364. Lara_isomerase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF50443. Fuc_isomerase_C. 1 hit. SSF53743. Fuc_isomerase_N. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARAA_AERHH

Accession

Primary (citable) accession number: A0KJI0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	December 12, 2006
Last modified:	December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program