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Protein

Cytidine deaminase

Gene

cdd

Organism
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.UniRule annotation

Catalytic activityi

Cytidine + H2O = uridine + NH3.UniRule annotation
2'deoxycytidine + H2O = 2'-deoxyuridine + NH3.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi101Zinc; catalyticUniRule annotation1
Active sitei103Proton donorUniRule annotation1
Metal bindingi128Zinc; catalyticUniRule annotation1
Metal bindingi131Zinc; catalyticUniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cytidine deaminaseUniRule annotation (EC:3.5.4.5UniRule annotation)
Alternative name(s):
Cytidine aminohydrolaseUniRule annotation
Short name:
CDAUniRule annotation
Gene namesi
Name:cddUniRule annotation
Ordered Locus Names:AHA_1894
OrganismiAeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240)
Taxonomic identifieri380703 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas
Proteomesi
  • UP000000756 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000689451 – 293Cytidine deaminaseAdd BLAST293

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi380703.AHA_1894.

Structurei

3D structure databases

ProteinModelPortaliA0KJH4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 166CMP/dCMP-type deaminase 1PROSITE-ProRule annotationAdd BLAST120
Domaini186 – 293CMP/dCMP-type deaminase 2PROSITE-ProRule annotationAdd BLAST108

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni88 – 90Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the cytidine and deoxycytidylate deaminase family.UniRule annotation
Contains 2 CMP/dCMP-type deaminase domains.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4107T42. Bacteria.
COG0295. LUCA.
HOGENOMiHOG000218617.
KOiK01489.
OMAiNQSHAPY.

Family and domain databases

HAMAPiMF_01558. Cyt_deam. 1 hit.
InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR013171. Cyd/dCyd_deaminase_Zn-bd.
IPR006263. Cyt_deam_dimer.
IPR016193. Cytidine_deaminase-like.
IPR020797. Cytidine_deaminase_bacteria.
[Graphical view]
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
PF08211. dCMP_cyt_deam_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006334. Cdd_plus_pseudo. 1 hit.
SUPFAMiSSF53927. SSF53927. 2 hits.
TIGRFAMsiTIGR01355. cyt_deam_dimer. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES_1. 1 hit.
PS51747. CYT_DCMP_DEAMINASES_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0KJH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPRFAKPLD TLSAPLKAAL LPMLGDDFQA RFTPDQVATL KAATGLDDRA
60 70 80 90 100
LRLALLPLAA ACSVAPISKF FVGAIACGLS GNWYFGANME FAGQGLFHSV
110 120 130 140 150
HAEQSAISNA WLGGETGISE ITVNYTPCGH CRQFMNELST AKILKVSLPD
160 170 180 190 200
DLSALQSFLP HSFGPADLDI TDALMSPQAH DELTLVSDDP LWQAALAAAR
210 220 230 240 250
QSYAPYSQGY AAVALQFADG RIFCGRYAEN AAFNPSLPPM QMACAHAVLG
260 270 280 290
GEDLATIRRA VLLESKDGQI SQQDSARATL KALGSVELEY QAV
Length:293
Mass (Da):31,202
Last modified:December 12, 2006 - v1
Checksum:i48C342569AD0C2A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000462 Genomic DNA. Translation: ABK36838.1.
RefSeqiWP_011705769.1. NC_008570.1.
YP_856425.1. NC_008570.1.

Genome annotation databases

EnsemblBacteriaiABK36838; ABK36838; AHA_1894.
GeneIDi4488666.
KEGGiaha:AHA_1894.
PATRICi20781370. VBIAerHyd135212_1906.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000462 Genomic DNA. Translation: ABK36838.1.
RefSeqiWP_011705769.1. NC_008570.1.
YP_856425.1. NC_008570.1.

3D structure databases

ProteinModelPortaliA0KJH4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi380703.AHA_1894.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK36838; ABK36838; AHA_1894.
GeneIDi4488666.
KEGGiaha:AHA_1894.
PATRICi20781370. VBIAerHyd135212_1906.

Phylogenomic databases

eggNOGiENOG4107T42. Bacteria.
COG0295. LUCA.
HOGENOMiHOG000218617.
KOiK01489.
OMAiNQSHAPY.

Family and domain databases

HAMAPiMF_01558. Cyt_deam. 1 hit.
InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR013171. Cyd/dCyd_deaminase_Zn-bd.
IPR006263. Cyt_deam_dimer.
IPR016193. Cytidine_deaminase-like.
IPR020797. Cytidine_deaminase_bacteria.
[Graphical view]
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
PF08211. dCMP_cyt_deam_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006334. Cdd_plus_pseudo. 1 hit.
SUPFAMiSSF53927. SSF53927. 2 hits.
TIGRFAMsiTIGR01355. cyt_deam_dimer. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES_1. 1 hit.
PS51747. CYT_DCMP_DEAMINASES_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDD_AERHH
AccessioniPrimary (citable) accession number: A0KJH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 12, 2006
Last modified: November 2, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.