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A0KJ55

- NUON_AERHH

UniProt

A0KJ55 - NUON_AERHH

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Protein

NADH-quinone oxidoreductase subunit N

Gene

nuoN

Organism
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

Catalytic activityi

NADH + quinone = NAD+ + quinol.UniRule annotation

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: InterPro
  2. quinone binding Source: UniProtKB-KW

GO - Biological processi

  1. ATP synthesis coupled electron transport Source: InterPro
  2. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Transport

Keywords - Ligandi

NAD, Ubiquinone

Enzyme and pathway databases

BioCyciAHYD380703:GH2M-1770-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit NUniRule annotation (EC:1.6.99.5UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit NUniRule annotation
NDH-1 subunit NUniRule annotation
Gene namesi
Name:nuoNUniRule annotation
Ordered Locus Names:AHA_1770
OrganismiAeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
Taxonomic identifieri380703 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas
ProteomesiUP000000756: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 487487NADH-quinone oxidoreductase subunit NPRO_0000391091Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

Protein-protein interaction databases

STRINGi380703.AHA_1770.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821HelicalUniRule annotationAdd
BLAST
Transmembranei37 – 5721HelicalUniRule annotationAdd
BLAST
Transmembranei71 – 9121HelicalUniRule annotationAdd
BLAST
Transmembranei104 – 12421HelicalUniRule annotationAdd
BLAST
Transmembranei125 – 14521HelicalUniRule annotationAdd
BLAST
Transmembranei159 – 17921HelicalUniRule annotationAdd
BLAST
Transmembranei203 – 22321HelicalUniRule annotationAdd
BLAST
Transmembranei235 – 25521HelicalUniRule annotationAdd
BLAST
Transmembranei269 – 28921HelicalUniRule annotationAdd
BLAST
Transmembranei303 – 32321HelicalUniRule annotationAdd
BLAST
Transmembranei327 – 34721HelicalUniRule annotationAdd
BLAST
Transmembranei374 – 39421HelicalUniRule annotationAdd
BLAST
Transmembranei408 – 42720HelicalUniRule annotationAdd
BLAST
Transmembranei449 – 46921HelicalUniRule annotationAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 2 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1007.
HOGENOMiHOG000100796.
KOiK00343.
OMAiSIVQLAM.
OrthoDBiEOG64JFNZ.

Family and domain databases

HAMAPiMF_00445. NDH1_NuoN_1.
InterProiIPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01770. NDH_I_N. 1 hit.

Sequencei

Sequence statusi: Complete.

A0KJ55-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTFTASQLLA LLPLLLTTGA MVALMLAIAW KRCDDTAFVV TIAGLNLALF
60 70 80 90 100
SLPIVMAQGD QGVTPLLQID GYAVFYMGLV LIGALATCTF GRSWLKGYPD
110 120 130 140 150
NREEFYLLLL IATAGGLVLA GSRHLASLFI GIEMLTLPMF GLVGYAYRER
160 170 180 190 200
HSLEASIKYM VLSAAATAFL LFGMALLYAQ AGSLSFSDLG LTLATTPAHH
210 220 230 240 250
PLLMGGLGLM LVGFAFKLSL APFHLWTPDV YEGAPAPVAT FLATVSKIAV
260 270 280 290 300
FCVLLRFYLA VPAAADPMIH WLLAAMAVIS IVIGNLLALL QTNIKRMMGY
310 320 330 340 350
SSISHFGYLL AVIVASRLGQ MPVEAAGVYL LMYLFTSLGA FGVISMMSSP
360 370 380 390 400
YRGKDADSLH SYRGLFWRRP YLTAVLTVMM LSLAGIPMTL GFIGKFYLIG
410 420 430 440 450
VTVDAKLWWL SGAIVLGSAL GLYYYLRVMV TLYLREPGMQ LRDAKGDWAI
460 470 480
TSGGLVVLLS AALVVALGLY PQPVISLVQG FQNVVLH
Length:487
Mass (Da):52,486
Last modified:December 12, 2006 - v1
Checksum:i55445AC63FC249F0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000462 Genomic DNA. Translation: ABK39107.1.
RefSeqiWP_011705656.1. NC_008570.1.
YP_856306.1. NC_008570.1.

Genome annotation databases

EnsemblBacteriaiABK39107; ABK39107; AHA_1770.
GeneIDi4486788.
KEGGiaha:AHA_1770.
PATRICi20781120. VBIAerHyd135212_1786.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000462 Genomic DNA. Translation: ABK39107.1 .
RefSeqi WP_011705656.1. NC_008570.1.
YP_856306.1. NC_008570.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 380703.AHA_1770.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK39107 ; ABK39107 ; AHA_1770 .
GeneIDi 4486788.
KEGGi aha:AHA_1770.
PATRICi 20781120. VBIAerHyd135212_1786.

Phylogenomic databases

eggNOGi COG1007.
HOGENOMi HOG000100796.
KOi K00343.
OMAi SIVQLAM.
OrthoDBi EOG64JFNZ.

Enzyme and pathway databases

BioCyci AHYD380703:GH2M-1770-MONOMER.

Family and domain databases

HAMAPi MF_00445. NDH1_NuoN_1.
InterProi IPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
[Graphical view ]
Pfami PF00361. Oxidored_q1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01770. NDH_I_N. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 7966 / NCIB 9240.

Entry informationi

Entry nameiNUON_AERHH
AccessioniPrimary (citable) accession number: A0KJ55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: December 12, 2006
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3