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A0KJ55

- NUON_AERHH

UniProt

A0KJ55 - NUON_AERHH

Protein

NADH-quinone oxidoreductase subunit N

Gene

nuoN

Organism
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

    Catalytic activityi

    NADH + quinone = NAD+ + quinol.UniRule annotation

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: InterPro
    2. quinone binding Source: UniProtKB-KW

    GO - Biological processi

    1. ATP synthesis coupled electron transport Source: InterPro
    2. transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    NAD, Ubiquinone

    Enzyme and pathway databases

    BioCyciAHYD380703:GH2M-1770-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-quinone oxidoreductase subunit NUniRule annotation (EC:1.6.99.5UniRule annotation)
    Alternative name(s):
    NADH dehydrogenase I subunit NUniRule annotation
    NDH-1 subunit NUniRule annotation
    Gene namesi
    Name:nuoNUniRule annotation
    Ordered Locus Names:AHA_1770
    OrganismiAeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
    Taxonomic identifieri380703 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas
    ProteomesiUP000000756: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 487487NADH-quinone oxidoreductase subunit NPRO_0000391091Add
    BLAST

    Keywords - PTMi

    Quinone

    Interactioni

    Subunit structurei

    NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi380703.AHA_1770.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821HelicalUniRule annotationAdd
    BLAST
    Transmembranei37 – 5721HelicalUniRule annotationAdd
    BLAST
    Transmembranei71 – 9121HelicalUniRule annotationAdd
    BLAST
    Transmembranei104 – 12421HelicalUniRule annotationAdd
    BLAST
    Transmembranei125 – 14521HelicalUniRule annotationAdd
    BLAST
    Transmembranei159 – 17921HelicalUniRule annotationAdd
    BLAST
    Transmembranei203 – 22321HelicalUniRule annotationAdd
    BLAST
    Transmembranei235 – 25521HelicalUniRule annotationAdd
    BLAST
    Transmembranei269 – 28921HelicalUniRule annotationAdd
    BLAST
    Transmembranei303 – 32321HelicalUniRule annotationAdd
    BLAST
    Transmembranei327 – 34721HelicalUniRule annotationAdd
    BLAST
    Transmembranei374 – 39421HelicalUniRule annotationAdd
    BLAST
    Transmembranei408 – 42720HelicalUniRule annotationAdd
    BLAST
    Transmembranei449 – 46921HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I subunit 2 family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1007.
    HOGENOMiHOG000100796.
    KOiK00343.
    OMAiSIVQLAM.
    OrthoDBiEOG64JFNZ.

    Family and domain databases

    HAMAPiMF_00445. NDH1_NuoN_1.
    InterProiIPR010096. NADH-Q_OxRdtase_suN/2.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    [Graphical view]
    PfamiPF00361. Oxidored_q1. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01770. NDH_I_N. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A0KJ55-1 [UniParc]FASTAAdd to Basket

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    MTFTASQLLA LLPLLLTTGA MVALMLAIAW KRCDDTAFVV TIAGLNLALF    50
    SLPIVMAQGD QGVTPLLQID GYAVFYMGLV LIGALATCTF GRSWLKGYPD 100
    NREEFYLLLL IATAGGLVLA GSRHLASLFI GIEMLTLPMF GLVGYAYRER 150
    HSLEASIKYM VLSAAATAFL LFGMALLYAQ AGSLSFSDLG LTLATTPAHH 200
    PLLMGGLGLM LVGFAFKLSL APFHLWTPDV YEGAPAPVAT FLATVSKIAV 250
    FCVLLRFYLA VPAAADPMIH WLLAAMAVIS IVIGNLLALL QTNIKRMMGY 300
    SSISHFGYLL AVIVASRLGQ MPVEAAGVYL LMYLFTSLGA FGVISMMSSP 350
    YRGKDADSLH SYRGLFWRRP YLTAVLTVMM LSLAGIPMTL GFIGKFYLIG 400
    VTVDAKLWWL SGAIVLGSAL GLYYYLRVMV TLYLREPGMQ LRDAKGDWAI 450
    TSGGLVVLLS AALVVALGLY PQPVISLVQG FQNVVLH 487
    Length:487
    Mass (Da):52,486
    Last modified:December 12, 2006 - v1
    Checksum:i55445AC63FC249F0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000462 Genomic DNA. Translation: ABK39107.1.
    RefSeqiYP_856306.1. NC_008570.1.

    Genome annotation databases

    EnsemblBacteriaiABK39107; ABK39107; AHA_1770.
    GeneIDi4486788.
    KEGGiaha:AHA_1770.
    PATRICi20781120. VBIAerHyd135212_1786.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000462 Genomic DNA. Translation: ABK39107.1 .
    RefSeqi YP_856306.1. NC_008570.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 380703.AHA_1770.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK39107 ; ABK39107 ; AHA_1770 .
    GeneIDi 4486788.
    KEGGi aha:AHA_1770.
    PATRICi 20781120. VBIAerHyd135212_1786.

    Phylogenomic databases

    eggNOGi COG1007.
    HOGENOMi HOG000100796.
    KOi K00343.
    OMAi SIVQLAM.
    OrthoDBi EOG64JFNZ.

    Enzyme and pathway databases

    BioCyci AHYD380703:GH2M-1770-MONOMER.

    Family and domain databases

    HAMAPi MF_00445. NDH1_NuoN_1.
    InterProi IPR010096. NADH-Q_OxRdtase_suN/2.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    [Graphical view ]
    Pfami PF00361. Oxidored_q1. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01770. NDH_I_N. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 7966 / NCIB 9240.

    Entry informationi

    Entry nameiNUON_AERHH
    AccessioniPrimary (citable) accession number: A0KJ55
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 9, 2010
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3