Reviewed, UniProtKB/Swiss-Prot A0KJ03 (GCST_AERHH)

Names and origin

Protein names

Recommended name:
    Aminomethyltransferase
    EC=2.1.2.10
Alternative name(s):
    Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	AHA_1718

Organism

Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) [Complete proteome] [HAMAP]

Taxonomic identifier

380703 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity. HAMAP MF_00259
Sequence similarities	Belongs to the gcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: HAMAP transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 365	365	Aminomethyltransferase HAMAP MF_00259		PRO_1000047641

Sequences

	Sequence		Length	Mass (Da)
	A0KJ03-1 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 1E5E390E15C1FF80	FASTA	365	39,715
	10 20 30 40 50 60 MIQTTVLHPK HLEAGAKMVD FHGWEMPINY GSQLEEHHQV RTDAGMFDVS HMTIVDLTGE 70 80 90 100 110 120 RVKAFLQHLL ANDVAKLTVF GKALYSGMLT PEGGVIDDLI TYYLGETFYR LVVNSATREK 130 140 150 160 170 180 DLAWIRHHAQ DFGVTVTERP ELAMIAVQGS NAKAKAAKVF SAEQNAAVEG MKPFFGVQAG 190 200 210 220 230 240 ELFIATTGYT GEDGYEIVVP QEQACDLWQA LLDNGVAPCG LGARDTLRLE AGMNLYGQDM 250 260 270 280 290 300 DETVSPLAAN MAWTIAWEPS DRQFIGRAAL EAQKAAGSQP KLVGLVMEEK GVLRSGMPVT 310 320 330 340 350 360 FTTAAGEERE GVITSGSFSP TLGYSIALAR VPRDIGEQAS VEIRKKLVTV KVTKPAFVRN GQKLV

References

[1]

"Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades." Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.H., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F. J. Bacteriol. 188:8272-8282(2006) [PubMed: 16980456] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000462 Genomic DNA. Translation: ABK37780.1.
RefSeq	YP_856254.1.
3D structure databases
SMR	A0KJ03. Positions 5-364.
ModBase	Search...
Protein-protein interaction databases
STRING	A0KJ03.
Genome annotation databases
GeneID	4488170.
GenomeReviews	Gene locus AHA_1718 in contig CP000462_GR.
KEGG	aha:AHA_1718.
TIGR	AHA_1718.
Phylogenomic databases
eggNOG	COG0404.
HOGENOM	HBG299834.
OMA	KALYGGM.
PhylomeDB	A0KJ03.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. [Graphical view]
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. gcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_AERHH

Accession

Primary (citable) accession number: A0KJ03

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	December 12, 2006
Last modified:	February 9, 2010
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)