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A0KJ03 (GCST_AERHH) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Aminomethyltransferase
EC=2.1.2.10
Alternative name(s):
Glycine cleavage system T protein
Gene names
Name:gcvT
Ordered Locus Names:AHA_1718
OrganismAeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) [Complete proteome] [HAMAP]
Taxonomic identifier380703 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length365 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259

Catalytic activity

[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvT family.

Ontologies

Keywords
   Molecular functionAminotransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycine catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular functionaminomethyltransferase activity

Inferred from electronic annotation. Source: EC

transaminase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 365365Aminomethyltransferase HAMAP MF_00259
PRO_1000047641

Sequences

Sequence LengthMass (Da)Tools
A0KJ03 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 1E5E390E15C1FF80

FASTA36539,715
        10         20         30         40         50         60 
MIQTTVLHPK HLEAGAKMVD FHGWEMPINY GSQLEEHHQV RTDAGMFDVS HMTIVDLTGE 

        70         80         90        100        110        120 
RVKAFLQHLL ANDVAKLTVF GKALYSGMLT PEGGVIDDLI TYYLGETFYR LVVNSATREK 

       130        140        150        160        170        180 
DLAWIRHHAQ DFGVTVTERP ELAMIAVQGS NAKAKAAKVF SAEQNAAVEG MKPFFGVQAG 

       190        200        210        220        230        240 
ELFIATTGYT GEDGYEIVVP QEQACDLWQA LLDNGVAPCG LGARDTLRLE AGMNLYGQDM 

       250        260        270        280        290        300 
DETVSPLAAN MAWTIAWEPS DRQFIGRAAL EAQKAAGSQP KLVGLVMEEK GVLRSGMPVT 

       310        320        330        340        350        360 
FTTAAGEERE GVITSGSFSP TLGYSIALAR VPRDIGEQAS VEIRKKLVTV KVTKPAFVRN 


GQKLV

« Hide

References

[1]"Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades."
Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.H., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.
J. Bacteriol. 188:8272-8282(2006) [PubMed: 16980456] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 7966 / NCIB 9240.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000462 Genomic DNA. Translation: ABK37780.1.
RefSeqYP_856254.1. NC_008570.1.

3D structure databases

ProteinModelPortalA0KJ03.
SMRA0KJ03. Positions 5-364.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0KJ03.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4488170.
GenomeReviewsGene locus AHA_1718 in contig CP000462_GR.
KEGGaha:AHA_1718.
PATRIC20781014. VBIAerHyd135212_1733.
TIGRAHA_1718.

Phylogenomic databases

eggNOGCOG0404.
HOGENOMHBG299834.
OMAKALYGGM.
PhylomeDBA0KJ03.
ProtClustDBPRK00389.

Enzyme and pathway databases

BioCycAHYD196024:AHA_1718-MONOMER.

Family and domain databases

HAMAPMF_00259. GcvT.
[Tree]
InterProIPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR006223. GcvT.
IPR022903. NH2_Me_Trfase.
[Graphical view]
KOK00605.
PANTHERPTHR13847:SF5. PTHR13847:SF5. 1 hit.
PfamPF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view]
PIRSFPIRSF006487. GcvT. 1 hit.
TIGRFAMsTIGR00528. GcvT. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCST_AERHH
AccessionPrimary (citable) accession number: A0KJ03
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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