Reviewed, UniProtKB/Swiss-Prot A0KIP8 (SPEA_AERHH)

Names and origin

Protein names

Recommended name:
    Biosynthetic arginine decarboxylase
      Short name=ADC
    EC=4.1.1.19

Gene names

Name:	speA
Ordered Locus Names:	AHA_1613

Organism

Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) [Complete proteome] [HAMAP]

Taxonomic identifier

380703 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length	633 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the biosynthesis of agmatine from arginine By similarity.
Catalytic activity	L-arginine = agmatine + CO2. HAMAP MF_01417
Cofactor	Magnesium By similarity. Pyridoxal phosphate By similarity.
Pathway	Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1. HAMAP MF_01417
Sequence similarities	Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Ontologies

Keywords
Biological process	Polyamine biosynthesis Spermidine biosynthesis
Ligand	Magnesium Metal-binding Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process Inferred from electronic annotation. Source: InterPro spermidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	arginine decarboxylase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 633	633	Biosynthetic arginine decarboxylase HAMAP MF_01417		PRO_1000024251
Regions
	Region	284 – 294	11	Substrate-binding Potential
Amino acid modifications
	Modified residue	101	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0KIP8-1 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 4D1B8EDFA2EE42A4	FASTA	633	70,227
	10 20 30 40 50 60 MTNWSSKDSL KVYNVPYWGA GFFNINDAGH VTVAPDKSRP DAQIVLSDAI EQLRQSGLTT 70 80 90 100 110 120 PVLLRFPDIL KSRVDALFNA FGQAIEKSGY EGDYLCVYPI KVNQQRRVIE TISQSYSDKP 130 140 150 160 170 180 RLGLEAGSKP ELLAVLSHHH EQGSVIVCNG YKDREYIRHA LLGNLMGHKV YIVVEKPSEL 190 200 210 220 230 240 EMVLDESARL NIKPNIGVRA KLASTGSGMW ESSGGSMSKF GLSASQILAL IERLRGLGKL 250 260 270 280 290 300 DCLQLLHFHL GSQIANIRDI QGGIRECGRF YAELRRLGAN IEVVDVGGGL GVDYEGTRSQ 310 320 330 340 350 360 SHCSANYSLS EYANNVVWGI GDVCREFDLP HPTIISESGR ALTAHHAVLV TNIIGAEGVE 370 380 390 400 410 420 MNDISAPDDD APTILQNMWK GWLDLRSEDP SLLEIFHDSV ADLGDVNTQY TMGLLNLEQR 430 440 450 460 470 480 AWAEMLHQNT CLALKELLNP VNRNHRALAD ELSEKLADKC FANFSLFQSL PDAWGIGQVF 490 500 510 520 530 540 PVMPLAGLER PLTRRGILMD ITCDSDGQVE HYVDGLGVES TLPMPVYGEH EECHVGFFLV 550 560 570 580 590 600 GAYQEILGDL HNLFGDTHCA EVWLDDEGKM DIRNVVRGDT VDQLLRYVNI DPSVIRENYQ 610 620 630 RIVSHPALDD ATRKALLDEL ELGLQGYAYL EDE

References

[1]

"Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades." Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.H., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F. J. Bacteriol. 188:8272-8282(2006) [PubMed: 16980456] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000462 Genomic DNA. Translation: ABK38605.1.
RefSeq	YP_856149.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A0KIP8.
Genome annotation databases
GeneID	4489158.
GenomeReviews	Gene locus AHA_1613 in contig CP000462_GR.
KEGG	aha:AHA_1613.
TIGR	AHA_1613.
Phylogenomic databases
OMA	LICNGYK.
Family and domain databases
HAMAP	MF_01417. [Tree]
InterPro	IPR002985. Arg_decrbxlase. IPR000183. De-COase2. [Graphical view]
PANTHER	PTHR11482:SF3. Arg_decrbxlase. 1 hit.
Pfam	PF02784. Orn_Arg_deC_N. 1 hit. PF00278. Orn_DAP_Arg_deC. 1 hit. [Graphical view]
PIRSF	PIRSF001336. Arg_decrbxlase. 1 hit.
PRINTS	PR01180. ARGDCRBXLASE. PR01179. ODADCRBXLASE.
TIGRFAMs	TIGR01273. speA. 1 hit.
PROSITE	PS00878. ODR_DC_2_1. False negative. PS00879. ODR_DC_2_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SPEA_AERHH

Accession

Primary (citable) accession number: A0KIP8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	December 12, 2006
Last modified:	November 3, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)