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A0KIP8 (SPEA_AERHH) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Biosynthetic arginine decarboxylase

Short name=ADC
EC=4.1.1.19
Gene names
Name:speA
Ordered Locus Names:AHA_1613
OrganismAeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) [Complete proteome] [HAMAP]
Taxonomic identifier380703 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas

Protein attributes

Sequence length633 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the biosynthesis of agmatine from arginine By similarity. HAMAP-Rule MF_01417

Catalytic activity

L-arginine = agmatine + CO2. HAMAP-Rule MF_01417

Cofactor

Magnesium By similarity. HAMAP-Rule MF_01417

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01417

Pathway

Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1. HAMAP-Rule MF_01417

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 633633Biosynthetic arginine decarboxylase HAMAP-Rule MF_01417
PRO_1000024251

Regions

Region284 – 29411Substrate-binding Potential

Amino acid modifications

Modified residue1011N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A0KIP8 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 4D1B8EDFA2EE42A4

FASTA63370,227
        10         20         30         40         50         60 
MTNWSSKDSL KVYNVPYWGA GFFNINDAGH VTVAPDKSRP DAQIVLSDAI EQLRQSGLTT 

        70         80         90        100        110        120 
PVLLRFPDIL KSRVDALFNA FGQAIEKSGY EGDYLCVYPI KVNQQRRVIE TISQSYSDKP 

       130        140        150        160        170        180 
RLGLEAGSKP ELLAVLSHHH EQGSVIVCNG YKDREYIRHA LLGNLMGHKV YIVVEKPSEL 

       190        200        210        220        230        240 
EMVLDESARL NIKPNIGVRA KLASTGSGMW ESSGGSMSKF GLSASQILAL IERLRGLGKL 

       250        260        270        280        290        300 
DCLQLLHFHL GSQIANIRDI QGGIRECGRF YAELRRLGAN IEVVDVGGGL GVDYEGTRSQ 

       310        320        330        340        350        360 
SHCSANYSLS EYANNVVWGI GDVCREFDLP HPTIISESGR ALTAHHAVLV TNIIGAEGVE 

       370        380        390        400        410        420 
MNDISAPDDD APTILQNMWK GWLDLRSEDP SLLEIFHDSV ADLGDVNTQY TMGLLNLEQR 

       430        440        450        460        470        480 
AWAEMLHQNT CLALKELLNP VNRNHRALAD ELSEKLADKC FANFSLFQSL PDAWGIGQVF 

       490        500        510        520        530        540 
PVMPLAGLER PLTRRGILMD ITCDSDGQVE HYVDGLGVES TLPMPVYGEH EECHVGFFLV 

       550        560        570        580        590        600 
GAYQEILGDL HNLFGDTHCA EVWLDDEGKM DIRNVVRGDT VDQLLRYVNI DPSVIRENYQ 

       610        620        630 
RIVSHPALDD ATRKALLDEL ELGLQGYAYL EDE 

« Hide

References

[1]"Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades."
Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.H., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.
J. Bacteriol. 188:8272-8282(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 7966 / NCIB 9240.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000462 Genomic DNA. Translation: ABK38605.1.
RefSeqYP_856149.1. NC_008570.1.

3D structure databases

ProteinModelPortalA0KIP8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING380703.AHA_1613.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK38605; ABK38605; AHA_1613.
GeneID4489158.
KEGGaha:AHA_1613.
PATRIC20780800. VBIAerHyd135212_1626.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1166.
HOGENOMHOG000029191.
KOK01585.
OMAIDHYVDG.
OrthoDBEOG676Z0R.

Enzyme and pathway databases

BioCycAHYD380703:GH2M-1613-MONOMER.
UniPathwayUPA00186; UER00284.

Family and domain databases

Gene3D2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPMF_01417. SpeA.
InterProIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMSSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR01273. speA. 1 hit.
PROSITEPS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSPEA_AERHH
AccessionPrimary (citable) accession number: A0KIP8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: June 11, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways