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A0KIN9

- FTHS_AERHH

UniProt

A0KIN9 - FTHS_AERHH

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi64 – 718ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAHYD380703:GH2M-1604-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:AHA_1604
OrganismiAeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
Taxonomic identifieri380703 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas
ProteomesiUP000000756: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 576576Formate--tetrahydrofolate ligasePRO_0000300514Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi380703.AHA_1604.

Structurei

3D structure databases

ProteinModelPortaliA0KIN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiQLRYIND.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0KIN9 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSDIEISRQ SPRLPIHALA ERLAIPSHQL HPYGHYKGKL SLELLKSLPK
60 70 80 90 100
PAGKLVLVSA ITPTPLGEGK TVTTLGLSMG LNHIGQPSIA TIRQPSLGPV
110 120 130 140 150
FGVKGGAAGG GHAQVVPMEE MNLHLTGDFH ALTAAHNLAA AALDARLFHE
160 170 180 190 200
RKLGDQFSAR TGLQRLDIDA DNILWPRTLD MNDRALRHLT IGQGNAADGV
210 220 230 240 250
ERSDRFVITA ASELMAILAL ASDLKDLRQR IGRIQLARDL RGKPITAEQL
260 270 280 290 300
EVAGAMTVLL KEALQPTLMQ TTEQTSVLVH AGPFANIAHG NSSVIADRMA
310 320 330 340 350
LGLTDYVVTE AGFGSDMGLE KFFNIKHRQS GITPACVVLV ATVRGLKANS
360 370 380 390 400
GLLDIRPGQP LPESLLREDL PTLEQGCANL GWHIANARRY GVPVVVAINR
410 420 430 440 450
FPTDSEAELA LLARAALRAG ACGSAISSAF TQGGAGASEL AQAVVAACEQ
460 470 480 490 500
PGKVKLLYPD QASLGAKLAT LVECGYGGRG VQLSDKARQQ LAQLSAEGWD
510 520 530 540 550
HLPVCVAKTP LSISHDPALK GVPTDFEVPI EEVKLCAGAG FVYALAGPIM
560 570
TMPGLGSLPA YRHIDIDDNG EIVGLS
Length:576
Mass (Da):60,860
Last modified:December 12, 2006 - v1
Checksum:iBF9395B9F24F6500
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000462 Genomic DNA. Translation: ABK36840.1.
RefSeqiYP_856140.1. NC_008570.1.

Genome annotation databases

EnsemblBacteriaiABK36840; ABK36840; AHA_1604.
GeneIDi4488356.
KEGGiaha:AHA_1604.
PATRICi20780780. VBIAerHyd135212_1616.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000462 Genomic DNA. Translation: ABK36840.1 .
RefSeqi YP_856140.1. NC_008570.1.

3D structure databases

ProteinModelPortali A0KIN9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 380703.AHA_1604.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK36840 ; ABK36840 ; AHA_1604 .
GeneIDi 4488356.
KEGGi aha:AHA_1604.
PATRICi 20780780. VBIAerHyd135212_1616.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi QLRYIND.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci AHYD380703:GH2M-1604-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 7966 / NCIB 9240.

Entry informationi

Entry nameiFTHS_AERHH
AccessioniPrimary (citable) accession number: A0KIN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 12, 2006
Last modified: October 1, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3