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A0KIN9

- FTHS_AERHH

UniProt

A0KIN9 - FTHS_AERHH

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi64 – 718ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAHYD380703:GH2M-1604-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:AHA_1604
    OrganismiAeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
    Taxonomic identifieri380703 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas
    ProteomesiUP000000756: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 576576Formate--tetrahydrofolate ligasePRO_0000300514Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi380703.AHA_1604.

    Structurei

    3D structure databases

    ProteinModelPortaliA0KIN9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiQLRYIND.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0KIN9-1 [UniParc]FASTAAdd to Basket

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    MLSDIEISRQ SPRLPIHALA ERLAIPSHQL HPYGHYKGKL SLELLKSLPK    50
    PAGKLVLVSA ITPTPLGEGK TVTTLGLSMG LNHIGQPSIA TIRQPSLGPV 100
    FGVKGGAAGG GHAQVVPMEE MNLHLTGDFH ALTAAHNLAA AALDARLFHE 150
    RKLGDQFSAR TGLQRLDIDA DNILWPRTLD MNDRALRHLT IGQGNAADGV 200
    ERSDRFVITA ASELMAILAL ASDLKDLRQR IGRIQLARDL RGKPITAEQL 250
    EVAGAMTVLL KEALQPTLMQ TTEQTSVLVH AGPFANIAHG NSSVIADRMA 300
    LGLTDYVVTE AGFGSDMGLE KFFNIKHRQS GITPACVVLV ATVRGLKANS 350
    GLLDIRPGQP LPESLLREDL PTLEQGCANL GWHIANARRY GVPVVVAINR 400
    FPTDSEAELA LLARAALRAG ACGSAISSAF TQGGAGASEL AQAVVAACEQ 450
    PGKVKLLYPD QASLGAKLAT LVECGYGGRG VQLSDKARQQ LAQLSAEGWD 500
    HLPVCVAKTP LSISHDPALK GVPTDFEVPI EEVKLCAGAG FVYALAGPIM 550
    TMPGLGSLPA YRHIDIDDNG EIVGLS 576
    Length:576
    Mass (Da):60,860
    Last modified:December 12, 2006 - v1
    Checksum:iBF9395B9F24F6500
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000462 Genomic DNA. Translation: ABK36840.1.
    RefSeqiYP_856140.1. NC_008570.1.

    Genome annotation databases

    EnsemblBacteriaiABK36840; ABK36840; AHA_1604.
    GeneIDi4488356.
    KEGGiaha:AHA_1604.
    PATRICi20780780. VBIAerHyd135212_1616.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000462 Genomic DNA. Translation: ABK36840.1 .
    RefSeqi YP_856140.1. NC_008570.1.

    3D structure databases

    ProteinModelPortali A0KIN9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 380703.AHA_1604.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK36840 ; ABK36840 ; AHA_1604 .
    GeneIDi 4488356.
    KEGGi aha:AHA_1604.
    PATRICi 20780780. VBIAerHyd135212_1616.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi QLRYIND.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci AHYD380703:GH2M-1604-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 7966 / NCIB 9240.

    Entry informationi

    Entry nameiFTHS_AERHH
    AccessioniPrimary (citable) accession number: A0KIN9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3