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A0KIK9

- GMHA_AERHH

UniProt

A0KIK9 - GMHA_AERHH

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Protein
Phosphoheptose isomerase
Gene
gmhA, AHA_1574
Organism
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate By similarity.UniRule annotation

Catalytic activityi

D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi61 – 611Zinc By similarity
Metal bindingi65 – 651Zinc By similarity
Binding sitei65 – 651Substrate By similarity
Binding sitei124 – 1241Substrate By similarity
Metal bindingi172 – 1721Zinc By similarity
Binding sitei172 – 1721Substrate By similarity
Metal bindingi180 – 1801Zinc By similarity

GO - Molecular functioni

  1. D-sedoheptulose 7-phosphate isomerase activity Source: UniProtKB-HAMAP
  2. carbohydrate binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-glycero-D-manno-heptose 7-phosphate biosynthetic process Source: UniProtKB-UniPathway
  2. lipopolysaccharide core region biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciAHYD380703:GH2M-1574-MONOMER.
UniPathwayiUPA00041; UER00436.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoheptose isomerase (EC:5.3.1.28)
Alternative name(s):
Sedoheptulose 7-phosphate isomerase
Gene namesi
Name:gmhA
Ordered Locus Names:AHA_1574
OrganismiAeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
Taxonomic identifieri380703 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas
ProteomesiUP000000756: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 192192Phosphoheptose isomeraseUniRule annotation
PRO_1000009047Add
BLAST

Proteomic databases

PRIDEiA0KIK9.

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi380703.AHA_1574.

Structurei

3D structure databases

ProteinModelPortaliA0KIK9.
SMRiA0KIK9. Positions 1-192.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 192156SIS
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni52 – 543Substrate binding By similarity
Regioni93 – 942Substrate binding By similarity
Regioni119 – 1213Substrate binding By similarity

Sequence similaritiesi

Belongs to the SIS family. GmhA subfamily.
Contains 1 SIS domain.

Phylogenomic databases

eggNOGiCOG0279.
HOGENOMiHOG000237571.
KOiK03271.
OMAiHVFSRYV.
OrthoDBiEOG6384PC.

Family and domain databases

HAMAPiMF_00067. GmhA.
InterProiIPR004515. Phosphoheptose_Isoase.
IPR001347. SIS.
[Graphical view]
PfamiPF13580. SIS_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00441. gmhA. 1 hit.
PROSITEiPS51464. SIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0KIK9-1 [UniParc]FASTAAdd to Basket

« Hide

MYQELIRNEL TEAASVLQAF LADEQNLKDI EAAAKLLADS FKQEGKVLSC    50
GNGGSHCDAM HFAEELTGRY RENRPGYAGI AISDPSHLSC VSNDFGYDYV 100
FSRYVEAVGR RGDVLLGIST SGNSGNILKA IEAAHAKGMK VIALTGKDGG 150
KMAGLADVEI RVPHFGYADR IQEVHIKVIH ILIQLVEKEM AK 192
Length:192
Mass (Da):20,868
Last modified:December 12, 2006 - v1
Checksum:iDDE30BA4C885CA57
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000462 Genomic DNA. Translation: ABK36369.1.
RefSeqiYP_856110.1. NC_008570.1.

Genome annotation databases

EnsemblBacteriaiABK36369; ABK36369; AHA_1574.
GeneIDi4487049.
KEGGiaha:AHA_1574.
PATRICi20780718. VBIAerHyd135212_1585.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000462 Genomic DNA. Translation: ABK36369.1 .
RefSeqi YP_856110.1. NC_008570.1.

3D structure databases

ProteinModelPortali A0KIK9.
SMRi A0KIK9. Positions 1-192.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 380703.AHA_1574.

Proteomic databases

PRIDEi A0KIK9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK36369 ; ABK36369 ; AHA_1574 .
GeneIDi 4487049.
KEGGi aha:AHA_1574.
PATRICi 20780718. VBIAerHyd135212_1585.

Phylogenomic databases

eggNOGi COG0279.
HOGENOMi HOG000237571.
KOi K03271.
OMAi HVFSRYV.
OrthoDBi EOG6384PC.

Enzyme and pathway databases

UniPathwayi UPA00041 ; UER00436 .
BioCyci AHYD380703:GH2M-1574-MONOMER.

Family and domain databases

HAMAPi MF_00067. GmhA.
InterProi IPR004515. Phosphoheptose_Isoase.
IPR001347. SIS.
[Graphical view ]
Pfami PF13580. SIS_2. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00441. gmhA. 1 hit.
PROSITEi PS51464. SIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 7966 / NCIB 9240.

Entry informationi

Entry nameiGMHA_AERHH
AccessioniPrimary (citable) accession number: A0KIK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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