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A0KHH6

- LPXB_AERHH

UniProt

A0KHH6 - LPXB_AERHH

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciAHYD380703:GH2M-1186-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:AHA_1186
    OrganismiAeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
    Taxonomic identifieri380703 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas
    ProteomesiUP000000756: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 379379Lipid-A-disaccharide synthasePRO_1000049382Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi380703.AHA_1186.

    Structurei

    3D structure databases

    ProteinModelPortaliA0KHH6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A0KHH6-1 [UniParc]FASTAAdd to Basket

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    MPDPVRIGIV AGEVSGDILA AGLVRELQAR YPDAQFEGIA GPRMQALGVK    50
    ALFEMEELSV MGITEVLGRL PRILKVRREL LRHFIANPPD IFIGVDAPDF 100
    NIGVELKLRR AGIKTVHYVS PSVWAWRQNR IHKIKAATDM VLAFLPFEKA 150
    FYDRFDAPCR FVGHTMADDI PLVPDQAAVR RTLGIDANRR WLAVLPGSRS 200
    AEVGFMSPLF LEACKHLTVR YPDLGFIVPL VNQKRREQFL AIKAELAPDL 250
    DMVLLEGQGR EAMIAADVVM LASGTAALEA MLVKKPMVVG YKLKPFSYWL 300
    AQRLVKTEFV SLPNLLAGRM LVPELIQHEC TPENLVVEVS KFFEHDNSAL 350
    VNTFTELHQL IRCNADQQAA EAVAELLGR 379
    Length:379
    Mass (Da):42,254
    Last modified:December 12, 2006 - v1
    Checksum:i9072311339DF4824
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000462 Genomic DNA. Translation: ABK36186.1.
    RefSeqiYP_855727.1. NC_008570.1.

    Genome annotation databases

    EnsemblBacteriaiABK36186; ABK36186; AHA_1186.
    GeneIDi4487261.
    KEGGiaha:AHA_1186.
    PATRICi20779926. VBIAerHyd135212_1193.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000462 Genomic DNA. Translation: ABK36186.1 .
    RefSeqi YP_855727.1. NC_008570.1.

    3D structure databases

    ProteinModelPortali A0KHH6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 380703.AHA_1186.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK36186 ; ABK36186 ; AHA_1186 .
    GeneIDi 4487261.
    KEGGi aha:AHA_1186.
    PATRICi 20779926. VBIAerHyd135212_1193.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci AHYD380703:GH2M-1186-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 7966 / NCIB 9240.

    Entry informationi

    Entry nameiLPXB_AERHH
    AccessioniPrimary (citable) accession number: A0KHH6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3