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A0KHH6

- LPXB_AERHH

UniProt

A0KHH6 - LPXB_AERHH

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, AHA_1186
Organism
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciAHYD380703:GH2M-1186-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:AHA_1186
OrganismiAeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
Taxonomic identifieri380703 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas
ProteomesiUP000000756: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 379379Lipid-A-disaccharide synthaseUniRule annotation
PRO_1000049382Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi380703.AHA_1186.

Structurei

3D structure databases

ProteinModelPortaliA0KHH6.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

A0KHH6-1 [UniParc]FASTAAdd to Basket

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MPDPVRIGIV AGEVSGDILA AGLVRELQAR YPDAQFEGIA GPRMQALGVK    50
ALFEMEELSV MGITEVLGRL PRILKVRREL LRHFIANPPD IFIGVDAPDF 100
NIGVELKLRR AGIKTVHYVS PSVWAWRQNR IHKIKAATDM VLAFLPFEKA 150
FYDRFDAPCR FVGHTMADDI PLVPDQAAVR RTLGIDANRR WLAVLPGSRS 200
AEVGFMSPLF LEACKHLTVR YPDLGFIVPL VNQKRREQFL AIKAELAPDL 250
DMVLLEGQGR EAMIAADVVM LASGTAALEA MLVKKPMVVG YKLKPFSYWL 300
AQRLVKTEFV SLPNLLAGRM LVPELIQHEC TPENLVVEVS KFFEHDNSAL 350
VNTFTELHQL IRCNADQQAA EAVAELLGR 379
Length:379
Mass (Da):42,254
Last modified:December 12, 2006 - v1
Checksum:i9072311339DF4824
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000462 Genomic DNA. Translation: ABK36186.1.
RefSeqiYP_855727.1. NC_008570.1.

Genome annotation databases

EnsemblBacteriaiABK36186; ABK36186; AHA_1186.
GeneIDi4487261.
KEGGiaha:AHA_1186.
PATRICi20779926. VBIAerHyd135212_1193.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000462 Genomic DNA. Translation: ABK36186.1 .
RefSeqi YP_855727.1. NC_008570.1.

3D structure databases

ProteinModelPortali A0KHH6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 380703.AHA_1186.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK36186 ; ABK36186 ; AHA_1186 .
GeneIDi 4487261.
KEGGi aha:AHA_1186.
PATRICi 20779926. VBIAerHyd135212_1193.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci AHYD380703:GH2M-1186-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 7966 / NCIB 9240.

Entry informationi

Entry nameiLPXB_AERHH
AccessioniPrimary (citable) accession number: A0KHH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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