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A0KHH6

- LPXB_AERHH

UniProt

A0KHH6 - LPXB_AERHH

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciAHYD380703:GH2M-1186-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:AHA_1186
OrganismiAeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
Taxonomic identifieri380703 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas
ProteomesiUP000000756: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 379379Lipid-A-disaccharide synthasePRO_1000049382Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi380703.AHA_1186.

Structurei

3D structure databases

ProteinModelPortaliA0KHH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

A0KHH6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPDPVRIGIV AGEVSGDILA AGLVRELQAR YPDAQFEGIA GPRMQALGVK
60 70 80 90 100
ALFEMEELSV MGITEVLGRL PRILKVRREL LRHFIANPPD IFIGVDAPDF
110 120 130 140 150
NIGVELKLRR AGIKTVHYVS PSVWAWRQNR IHKIKAATDM VLAFLPFEKA
160 170 180 190 200
FYDRFDAPCR FVGHTMADDI PLVPDQAAVR RTLGIDANRR WLAVLPGSRS
210 220 230 240 250
AEVGFMSPLF LEACKHLTVR YPDLGFIVPL VNQKRREQFL AIKAELAPDL
260 270 280 290 300
DMVLLEGQGR EAMIAADVVM LASGTAALEA MLVKKPMVVG YKLKPFSYWL
310 320 330 340 350
AQRLVKTEFV SLPNLLAGRM LVPELIQHEC TPENLVVEVS KFFEHDNSAL
360 370
VNTFTELHQL IRCNADQQAA EAVAELLGR
Length:379
Mass (Da):42,254
Last modified:December 12, 2006 - v1
Checksum:i9072311339DF4824
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000462 Genomic DNA. Translation: ABK36186.1.
RefSeqiYP_855727.1. NC_008570.1.

Genome annotation databases

EnsemblBacteriaiABK36186; ABK36186; AHA_1186.
GeneIDi4487261.
KEGGiaha:AHA_1186.
PATRICi20779926. VBIAerHyd135212_1193.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000462 Genomic DNA. Translation: ABK36186.1 .
RefSeqi YP_855727.1. NC_008570.1.

3D structure databases

ProteinModelPortali A0KHH6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 380703.AHA_1186.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK36186 ; ABK36186 ; AHA_1186 .
GeneIDi 4487261.
KEGGi aha:AHA_1186.
PATRICi 20779926. VBIAerHyd135212_1193.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci AHYD380703:GH2M-1186-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 7966 / NCIB 9240.

Entry informationi

Entry nameiLPXB_AERHH
AccessioniPrimary (citable) accession number: A0KHH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: October 1, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3