A0KGP5 (A0KGP5_AERHH) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137
EC=6.3.2.6 HAMAP MF_00137

Alternative name(s):
SAICAR synthetase HAMAP MF_00137

Gene names

Name:	purC HAMAP MF_00137 EMBL ABK39370.1
Ordered Locus Names:	AHA_0898

Organism

Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) [Complete proteome] [HAMAP]

Taxonomic identifier

380703 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length	371 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137 SAAS SAAS001636
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137 SAAS SAAS001636
Sequence similarities	Belongs to the SAICAR synthetase family. HAMAP MF_00137 RuleBase RU004193

Ontologies

Keywords
Biological process	Purine biosynthesis HAMAP MF_00137 SAAS SAAS001636
Ligand	ATP-binding HAMAP MF_00137 SAAS SAAS001636 Nucleotide-binding
Molecular function	Ligase HAMAP MF_00137 SAAS SAAS001636 EMBL ABK39370.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A0KGP5 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 1C6DF93D4A921AA6	FASTA	371	41,495
	10 20 30 40 50 60 MLLTMSLADQ VLAVNDDLPI RTDKPVHSGK VRSVYWLTAA DSARLIREKG YDVPADAPLA 70 80 90 100 110 120 IMVISDRISA FDCIWQGVDG LNGVPGKGAA LNAISSHWFK LFKEKGLADS HILDIPHPFV 130 140 150 160 170 180 WIVQKARPVM IEAIARQYIT GSMWRAYKDG EREFCGITLP EGLKKDQKLP EILITPSTKG 190 200 210 220 230 240 VLTGLDGVPE ADDVNVSRAD IERHYQGFNF SKPADIDRYE VLLKEGFSVI SDALAELDQI 250 260 270 280 290 300 FVDTKFEFGY VNDAAGNEKL IYMDEVGTPD SSRIWDGAAL RDGQIVEKSK EGFRQWLLNH 310 320 330 340 350 360 FPDPDILLNK HRMPERFALA RDNKLPTEVM MDISNTYVGI AEKIIGQPLV RSANPKQEII 370 EVLRAQYGLI D

References

[1]

"Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades." Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.H., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F. J. Bacteriol. 188:8272-8282(2006) [PubMed: 16980456] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000462 Genomic DNA. Translation: ABK39370.1.
RefSeq	YP_855441.1. NC_008570.1.
3D structure databases
ProteinModelPortal	A0KGP5.
ModBase	Search...
Protein-protein interaction databases
STRING	A0KGP5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4490870.
GenomeReviews	Gene locus AHA_0898 in contig CP000462_GR.
KEGG	aha:AHA_0898.
PATRIC	20779328. VBIAerHyd135212_0899.
TIGR	AHA_0898.
Phylogenomic databases
eggNOG	COG0152.
HOGENOM	HBG555040.
OMA	SSRIWDG.
PhylomeDB	A0KGP5.
ProtClustDB	PRK13960.
Family and domain databases
HAMAP	MF_00137. SAICAR_synth. [Tree]
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR014106. PurC_vibrio. IPR001636. SAICAR_synth. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
KO	K01923.
PANTHER	PTHR11609. SAICAR_synt. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
TIGRFAMs	TIGR02735. PurC_vibrio. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A0KGP5_AERHH

Accession

Primary (citable) accession number: A0KGP5

Entry history

Integrated into UniProtKB/TrEMBL:	December 12, 2006
Last sequence update:	December 12, 2006
Last modified:	December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)