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Protein

Aspartate ammonia-lyase

Gene

aspA

Organism
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-aspartate = fumarate + NH3.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotationImported

Enzyme and pathway databases

BioCyciAHYD380703:GH2M-857-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate ammonia-lyaseUniRule annotation (EC:4.3.1.1UniRule annotation)
Short name:
AspartaseUniRule annotation
Gene namesi
Name:aspAImported
Ordered Locus Names:AHA_0856Imported
OrganismiAeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240)Imported
Taxonomic identifieri380703 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas
Proteomesi
  • UP000000756 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi380703.AHA_0856.

Structurei

3D structure databases

ProteinModelPortaliA0KGK7.
SMRiA0KGK7. Positions 6-461.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 347333Lyase_1InterPro annotationAdd
BLAST
Domaini413 – 46553FumaraseC_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108IJ0. Bacteria.
COG1027. LUCA.
HOGENOMiHOG000061737.
KOiK01744.
OMAiEICENYV.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
InterProiIPR004708. ApsA.
IPR024083. Fumarase/histidase_N.
IPR018951. Fumarase_C_C.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF10415. FumaraseC_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00839. aspA. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0KGK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDIKNVRIE EDLLGTKEVS NDLYYGVHTL RAVENFKIST QKISDVPEFV
60 70 80 90 100
RGMVLTKKAA ALANGELGTI RPEIADKIVE ACDLMLNTGK CFDQFPVDVY
110 120 130 140 150
QGGAGTSVNM NTNEVLANIA LEIMGLAKGR YDVINPNDHV NKCQSTNDAY
160 170 180 190 200
PTGFRVAVVN STDTTLHALE ALIAAFDAKA AEFKGILKMG RTQLQDAVPM
210 220 230 240 250
TLGQEFHAFA VTLREEIKSI KRCQELLLEV NLGATAIGTG LNTPPEYSAL
260 270 280 290 300
AIKRLAEITG RAYVPAEDLI EATSDCGAYV MLHGAIKRMA MKLSKICNDL
310 320 330 340 350
RLLSSGPRTA LKEINLPEMQ AGSSIMPAKV NPVIPEVVNQ SCFKVFGNDV
360 370 380 390 400
TITFAAEAGQ LQLNVMEPVI GQAMFESLSL MEKACISLRE KCVEGITANP
410 420 430 440 450
EICMNHVLNS IGIVTYLNPF IGHHEGDIVG KICAQTGKNV REVVLERGLL
460 470 480
TAEQLDEILS IENLMNPQYK AKRYTREATV
Length:480
Mass (Da):52,338
Last modified:December 12, 2006 - v1
Checksum:i6B580E9C473BBE2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000462 Genomic DNA. Translation: ABK36406.1.
RefSeqiWP_011704801.1. NC_008570.1.
YP_855398.1. NC_008570.1.

Genome annotation databases

EnsemblBacteriaiABK36406; ABK36406; AHA_0856.
GeneIDi4487240.
KEGGiaha:AHA_0856.
PATRICi20779240. VBIAerHyd135212_0859.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000462 Genomic DNA. Translation: ABK36406.1.
RefSeqiWP_011704801.1. NC_008570.1.
YP_855398.1. NC_008570.1.

3D structure databases

ProteinModelPortaliA0KGK7.
SMRiA0KGK7. Positions 6-461.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi380703.AHA_0856.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK36406; ABK36406; AHA_0856.
GeneIDi4487240.
KEGGiaha:AHA_0856.
PATRICi20779240. VBIAerHyd135212_0859.

Phylogenomic databases

eggNOGiENOG4108IJ0. Bacteria.
COG1027. LUCA.
HOGENOMiHOG000061737.
KOiK01744.
OMAiEICENYV.

Enzyme and pathway databases

BioCyciAHYD380703:GH2M-857-MONOMER.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
InterProiIPR004708. ApsA.
IPR024083. Fumarase/histidase_N.
IPR018951. Fumarase_C_C.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF10415. FumaraseC_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00839. aspA. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA0KGK7_AERHH
AccessioniPrimary (citable) accession number: A0KGK7
Entry historyi
Integrated into UniProtKB/TrEMBL: December 12, 2006
Last sequence update: December 12, 2006
Last modified: September 7, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.