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A0KGD0 (A0KGD0_AERHH) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length396 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP-Rule MF_00218 SAAS SAAS006361

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP-Rule MF_00218 RuleBase RU000554 SAAS SAAS006361

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP-Rule MF_00218 RuleBase RU000554 SAAS SAAS006361

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00218 SAAS SAAS006361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00218 SAAS SAAS006361.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family. HAMAP-Rule MF_00218 RuleBase RU004169

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region68 – 725Substrate binding By similarity HAMAP-Rule MF_00218

Sites

Binding site1181Substrate By similarity HAMAP-Rule MF_00218
Binding site1951Substrate By similarity HAMAP-Rule MF_00218
Binding site2501Substrate By similarity HAMAP-Rule MF_00218
Binding site3681Substrate By similarity HAMAP-Rule MF_00218
Site1181Transition state stabilizer By similarity HAMAP-Rule MF_00218

Sequences

Sequence LengthMass (Da)Tools
A0KGD0 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: E57B132F6C3BD482

FASTA39644,140
        10         20         30         40         50         60 
MFAPLHIFAL QRRRQAFEPP PAAHKVVSYP PFYAGYDSGT GMKELKNDRY LRALLRQEVD 

        70         80         90        100        110        120 
MTPVWMMRQA GRYLPEYKAT RAQAGDFMSL CRNAELACEV TLQPLRRYPL DAAILFSDIL 

       130        140        150        160        170        180 
TVPDAMGLGL YFEQGEGPRF ERPITSMADV QALPVPDPED ELGYVMNAVR TIRRELKGEV 

       190        200        210        220        230        240 
PLIGFSGSPW TLATYMVEGG SSKAFTKIKQ MMYAEPQTLH LLLDKLADSV IAYLNAQIKA 

       250        260        270        280        290        300 
GAQAVMVFDT WGGVLTPRDY RDFSLQYMHK IVDGLIREHD GRRVPVTLFT KNGGQWLEQI 

       310        320        330        340        350        360 
AATGCDALGL DWTTDIADAK RRVGDKVALQ GNMDPSMLYA NPARIREEVA SILAGFGHGN 

       370        380        390 
GHVFNLGHGI HQDVNPEHAG VFVNAVHELS AQYHGR

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References

[1]"Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades."
Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.H., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.
J. Bacteriol. 188:8272-8282(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 7966 / NCIB 9240.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000462 Genomic DNA. Translation: ABK37428.1.
RefSeqYP_855320.1. NC_008570.1.

3D structure databases

ProteinModelPortalA0KGD0.
ModBaseSearch...

Protein-protein interaction databases

STRING380703.AHA_0778.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK37428; ABK37428; AHA_0778.
GeneID4487938.
KEGGaha:AHA_0778.
PATRIC20779072. VBIAerHyd135212_0776.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0407.
HOGENOMHOG000253896.
KOK01599.
OMATLATYMI.
ProtClustDBPRK00115.

Enzyme and pathway databases

BioCycAHYD380703:GH2M-909-MONOMER.
UniPathwayUPA00251; UER00321.

Family and domain databases

HAMAPMF_00218. URO_D.
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
PANTHERPTHR21091:SF2. PTHR21091:SF2. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. hemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA0KGD0_AERHH
AccessionPrimary (citable) accession number: A0KGD0
Entry history
Integrated into UniProtKB/TrEMBL: December 12, 2006
Last sequence update: December 12, 2006
Last modified: May 1, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info