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A0KFV4 (ARLY_AERHH) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:AHA_0597
OrganismAeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) [Complete proteome] [HAMAP]
Taxonomic identifier380703 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length461 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006

Subcellular location

Cytoplasm By similarity HAMAP MF_00006.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 461461Argininosuccinate lyase HAMAP MF_00006
PRO_1000000448

Sequences

Sequence LengthMass (Da)Tools
A0KFV4 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 8835D7E751FE8980

FASTA46150,266
        10         20         30         40         50         60 
MALWGGRFSQ GADSRFKQFN DSLRFDYRLA EQDIQGSMAW AKALVKVGVL TADEQGKLQQ 

        70         80         90        100        110        120 
AMEVLLASVQ QDPQQILISD AEDIHSWVES ALIAAVGDLG KKLHTGRSRN DQVATDLKLW 

       130        140        150        160        170        180 
CKAQGELLLG SITALQQGLV ASARANQAAV LPGYTHLQRA QPVTYAHWAL AYVEMLERDY 

       190        200        210        220        230        240 
SRLQDALKRL DTSPLGCGAL AGTAYAIDRE ALALDMGFAG ATRNSLDSVS DRDHVVELMH 

       250        260        270        280        290        300 
VASLSMTHLS RFAEDLIFYN TGEAGFVELS DAVTSGSSLM PQKKNPDALE LIRGKTGRVV 

       310        320        330        340        350        360 
GAQMGMLMSL KALPLAYNKD MQEDKEGLFD ALDTWHDCLD MAALVLIDLK VNGERTMAAA 

       370        380        390        400        410        420 
QGGYANATEL ADYLVAKGIP FREAHHIVGE TVVYAIQVKK PLEELTIGEF QRFSPVIEFD 

       430        440        450        460 
VYPNLELEAT LAKRVAKGGV AREQVEAALI AAETWLAKRA G

« Hide

References

[1]"Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades."
Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.H., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.
J. Bacteriol. 188:8272-8282(2006) [PubMed: 16980456] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 7966 / NCIB 9240.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000462 Genomic DNA. Translation: ABK36163.1.
RefSeqYP_855130.1. NC_008570.1.

3D structure databases

ProteinModelPortalA0KFV4.
SMRA0KFV4. Positions 3-457.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0KFV4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4489264.
GenomeReviewsGene locus AHA_0597 in contig CP000462_GR.
KEGGaha:AHA_0597.
PATRIC20778700. VBIAerHyd135212_0595.
TIGRAHA_0597.

Phylogenomic databases

eggNOGCOG0165.
HOGENOMHBG539632.
OMAMAEDLIF.
PhylomeDBA0KFV4.
ProtClustDBPRK00855.

Enzyme and pathway databases

BioCycAHYD196024:AHA_0597-MONOMER.

Family and domain databases

HAMAPMF_00006. Arg_succ_lyase.
[Tree]
InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR008948. L-Aspartase-like.
IPR022761. Lyase1_N.
[Graphical view]
KOK01755.
PANTHERPTHR11444:SF3. argH. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. ArgH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_AERHH
AccessionPrimary (citable) accession number: A0KFV4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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