Reviewed, UniProtKB/Swiss-Prot A0KFV4 (ARLY_AERHH)

Names and origin

Protein names

Recommended name:
    Argininosuccinate lyase
      Short name=ASAL
    EC=4.3.2.1
Alternative name(s):
    Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	AHA_0597

Organism

Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) [Complete proteome] [HAMAP]

Taxonomic identifier

380703 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length	461 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm Probable HAMAP MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 461	461	Argininosuccinate lyase HAMAP MF_00006		PRO_1000000448

Sequences

	Sequence		Length	Mass (Da)
	A0KFV4-1 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 8835D7E751FE8980	FASTA	461	50,266
	10 20 30 40 50 60 MALWGGRFSQ GADSRFKQFN DSLRFDYRLA EQDIQGSMAW AKALVKVGVL TADEQGKLQQ 70 80 90 100 110 120 AMEVLLASVQ QDPQQILISD AEDIHSWVES ALIAAVGDLG KKLHTGRSRN DQVATDLKLW 130 140 150 160 170 180 CKAQGELLLG SITALQQGLV ASARANQAAV LPGYTHLQRA QPVTYAHWAL AYVEMLERDY 190 200 210 220 230 240 SRLQDALKRL DTSPLGCGAL AGTAYAIDRE ALALDMGFAG ATRNSLDSVS DRDHVVELMH 250 260 270 280 290 300 VASLSMTHLS RFAEDLIFYN TGEAGFVELS DAVTSGSSLM PQKKNPDALE LIRGKTGRVV 310 320 330 340 350 360 GAQMGMLMSL KALPLAYNKD MQEDKEGLFD ALDTWHDCLD MAALVLIDLK VNGERTMAAA 370 380 390 400 410 420 QGGYANATEL ADYLVAKGIP FREAHHIVGE TVVYAIQVKK PLEELTIGEF QRFSPVIEFD 430 440 450 460 VYPNLELEAT LAKRVAKGGV AREQVEAALI AAETWLAKRA G

References

[1]

"Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades." Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.H., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F. J. Bacteriol. 188:8272-8282(2006) [PubMed: 16980456] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000462 Genomic DNA. Translation: ABK36163.1.
RefSeq	YP_855130.1.
3D structure databases
SMR	A0KFV4. Positions 3-457.
ModBase	Search...
Protein-protein interaction databases
STRING	A0KFV4.
Genome annotation databases
GeneID	4489264.
GenomeReviews	Gene locus AHA_0597 in contig CP000462_GR.
KEGG	aha:AHA_0597.
TIGR	AHA_0597.
Phylogenomic databases
eggNOG	COG0165.
HOGENOM	HBG539632.
OMA	MAEDLIF.
PhylomeDB	A0KFV4.
Family and domain databases
HAMAP	MF_00006. Arg_succ_lyase. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. IPR008948. L-Aspartase-like. [Graphical view]
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
TIGRFAMs	TIGR00838. argH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_AERHH

Accession

Primary (citable) accession number: A0KFV4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	December 12, 2006
Last modified:	February 9, 2010
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)