A0KFV1 (ARGB_AERHH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylglutamate kinase
EC=2.7.2.8

Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK

Gene names

Name:	argB
Ordered Locus Names:	AHA_0594

Organism

Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) [Complete proteome] [HAMAP]

Taxonomic identifier

380703 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length	259 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082_B
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00082_B.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetylglutamate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 259	259	Acetylglutamate kinase HAMAP MF_00082_B		PRO_1000092845
Regions
	Region	45 – 46	2	Substrate binding By similarity
Sites
	Binding site	67	1	Substrate By similarity
	Binding site	159	1	Substrate By similarity
	Site	9	1	Transition state stabilizer By similarity
	Site	218	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0KFV1 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 9874CB5A5CD74386	FASTA	259	26,455
	10 20 30 40 50 60 MDKQTLVIKL GGALIENDEA LTALFATLKT FLDEQHRPLV LVHGGGCLVD DLLKGLGLTS 70 80 90 100 110 120 TKKNGLRVTP FEQIPFIAGA LAGTANKMMM AKAIATDIPA VGLCLADGGL CQVTQLDPAL 130 140 150 160 170 180 GAVGDCQPGN PALVTGILGQ GFLPVVSSIG ITAQGQLMNV NADQAATAIA EALGADLVML 190 200 210 220 230 240 SDVSGILDGK GKLVPQLDKV TALDLMEKGV ISDGMAVKVK AALHAAETLG KPVCVASWRY 250 PDQLLKLLAG GAVGTQVAI

References

[1]

"Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades." Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.H., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F. J. Bacteriol. 188:8272-8282(2006) [PubMed: 16980456] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 7966 / NCIB 9240.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000462 Genomic DNA. Translation: ABK38661.1.
RefSeq	YP_855127.1. NC_008570.1.
3D structure databases
ProteinModelPortal	A0KFV1.
ModBase	Search...
Protein-protein interaction databases
STRING	A0KFV1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4489261.
GenomeReviews	Gene locus AHA_0594 in contig CP000462_GR.
KEGG	aha:AHA_0594.
PATRIC	20778692. VBIAerHyd135212_0591.
TIGR	AHA_0594.
Phylogenomic databases
eggNOG	COG0548.
HOGENOM	HBG497643.
OMA	GGCLVDD.
PhylomeDB	A0KFV1.
ProtClustDB	PRK00942.
Enzyme and pathway databases
BioCyc	AHYD196024:AHA_0594-MONOMER.
Family and domain databases
HAMAP	MF_00082_B. ArgB_B. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KO	K00930.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. ArgB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_AERHH

Accession

Primary (citable) accession number: A0KFV1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	December 12, 2006
Last modified:	December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program