Reviewed, UniProtKB/Swiss-Prot A0KFV0 (ARGC_AERHH)

Names and origin

Protein names

Recommended name:
    N-acetyl-gamma-glutamyl-phosphate reductase
      Short name=AGPR
    EC=1.2.1.38
Alternative name(s):
    N-acetyl-glutamate semialdehyde dehydrogenase
      Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	AHA_0593

Organism

Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) [Complete proteome] [HAMAP]

Taxonomic identifier

380703 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD or NADH binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 335	335	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_1000010971
Sites
	Active site	156	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0KFV0-1 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 57116D1349D99C5E	FASTA	335	36,045
	10 20 30 40 50 60 MLNTVIVGAS GYAGAELAAL VQNHPQLKLF GLYVSAGSQD AHKRFSSLHP QWVGALDQPL 70 80 90 100 110 120 LPLDEDGMTR ILTQADLVLL ATAHEVSATL APKFLAKGLP VFDLSGAFRV RDQQFYASYY 130 140 150 160 170 180 GFTHDSEQWL DQAAYGLAEW NAEAVKAAQL IAVPGCYPTA SLCALKPLQQ AGLIAKGWQP 190 200 210 220 230 240 IINAVSGVSG AGRKAAINTS FCEVSLNPYG TFNHRHQPEI SHHLGKEVLF QPHLGNYVRG 250 260 270 280 290 300 ILATIYVQLA DGVTPTQVDQ AYLKAYEGKP LVRLTGQMPS IRGVAGTPYC DLAWQQQGNM 310 320 330 LVVVCAIDNL LKGAASQAMQ CINIKFGFEP ATGLI

References

[1]

"Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades." Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.H., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F. J. Bacteriol. 188:8272-8282(2006) [PubMed: 16980456] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000462 Genomic DNA. Translation: ABK37991.1.
RefSeq	YP_855126.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4489260.
GenomeReviews	Gene locus AHA_0593 in contig CP000462_GR.
KEGG	aha:AHA_0593.
TIGR	AHA_0593.
Phylogenomic databases
OMA	A0KFV0. VCRIAVH.
Family and domain databases
HAMAP	MF_00150. [Tree]
InterPro	IPR000706. AGPR_act_site. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
ProDom	PD003765. AGPR_act_site. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01850. argC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_AERHH

Accession

Primary (citable) accession number: A0KFV0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	December 12, 2006
Last modified:	June 16, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)