ID   AROE_AERHH              Reviewed;         273 AA.
AC   A0KEX8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   16-JUN-2009, entry version 24.
DE   RecName: Full=Shikimate dehydrogenase;
DE            EC=1.1.1.25;
GN   Name=aroE; OrderedLocusNames=AHA_0266;
OS   Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=380703;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16980456; DOI=10.1128/JB.00621-06;
RA   Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J.,
RA   Haft D.H., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M.,
RA   Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
RT   "Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all
RT   trades.";
RL   J. Bacteriol. 188:8272-8282(2006).
CC   -!- CATALYTIC ACTIVITY: Shikimate + NADP(+) = 3-dehydroshikimate +
CC       NADPH.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and PEP:
CC       step 4/7.
CC   -!- SIMILARITY: Belongs to the shikimate dehydrogenase family.
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DR   EMBL; CP000462; ABK36524.1; -; Genomic_DNA.
DR   RefSeq; YP_854794.1; -.
DR   GeneID; 4490197; -.
DR   GenomeReviews; CP000462_GR; AHA_0266.
DR   KEGG; aha:AHA_0266; -.
DR   TIGR; AHA_0266; -.
DR   OMA; A0KEX8; YDMMYGR.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0050661; F:NADP or NADPH binding; IEA:InterPro.
DR   GO; GO:0004764; F:shikimate 5-dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00222; -; 1.
DR   InterPro; IPR011342; Quinate/shikimate_5-DH.
DR   InterPro; IPR013708; Shikimate_DH-bd_N.
DR   InterPro; IPR006151; Shikm_DH/Glu-tRNA_Rdtase.
DR   Pfam; PF01488; Shikimate_DH; 1.
DR   Pfam; PF08501; Shikimate_dh_N; 1.
DR   TIGRFAMs; TIGR00507; aroE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; NADP; Oxidoreductase.
FT   CHAIN         1    273       Shikimate dehydrogenase.
FT                                /FTId=PRO_1000021253.
FT   NP_BIND     126    130       NADP (By similarity).
FT   ACT_SITE     65     65       Proton acceptor (Potential).
SQ   SEQUENCE   273 AA;  29192 MW;  7D837CC96DD7FED7 CRC64;
     MDRYLVFGHP VRHSKSPFIH TLFARQTQQE LEYGLAEPAV EEFATSLRAF FAQGGKGCNV
     TVPFKEQAFA LVDRLSPRAR RAGAVNTIKL TDDGVLLGDN TDGAGLVADL KAHGVALAGS
     RILLLGAGGA ARGALAPLLA EQPEALVIAN RTHARAEQLA AEFRDLGAVS AQTYERLGGH
     FDLIINSTSA SLQGELPPLV PALIHADIAI YDMMYGATDT PFIAWAKGQG ARQTVDGLGM
     LVEQAAEAFT VWRGIRPGTK QVLRELKRNL GTL
//