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Protein

Glycerol-3-phosphate acyltransferase

Gene

plsB

Organism
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.UniRule annotation

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase (plsB)
  2. no protein annotated in this organism
  3. Phosphatidate cytidylyltransferase (cdsA)
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciAHYD380703:G1G7B-182-MONOMER
UniPathwayiUPA00557; UER00612

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate acyltransferaseUniRule annotation (EC:2.3.1.15UniRule annotation)
Short name:
GPATUniRule annotation
Gene namesi
Name:plsBUniRule annotation
Ordered Locus Names:AHA_0182
OrganismiAeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240)
Taxonomic identifieri380703 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas
Proteomesi
  • UP000000756 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000494271 – 807Glycerol-3-phosphate acyltransferaseAdd BLAST807

Proteomic databases

PRIDEiA0KEQ0

Interactioni

Protein-protein interaction databases

STRINGi380703.AHA_0182

Structurei

3D structure databases

ProteinModelPortaliA0KEQ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi309 – 314HXXXXD motif6

Domaini

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.UniRule annotation

Sequence similaritiesi

Belongs to the GPAT/DAPAT family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E55 Bacteria
COG2937 LUCA
HOGENOMiHOG000218231
KOiK00631
OMAiEVIYVPC

Family and domain databases

HAMAPiMF_00393 Glyc3P_acyltrans, 1 hit
InterProiView protein in InterPro
IPR022284 GPAT/DHAPAT
IPR028354 GPAT_PlsB
IPR002123 Plipid/glycerol_acylTrfase
PANTHERiPTHR12563 PTHR12563, 1 hit
PfamiView protein in Pfam
PF01553 Acyltransferase, 1 hit
PIRSFiPIRSF500064 GPAT, 1 hit
PIRSF000437 GPAT_DHAPAT, 1 hit
SMARTiView protein in SMART
SM00563 PlsC, 1 hit
TIGRFAMsiTIGR03703 plsB, 1 hit

Sequencei

Sequence statusi: Complete.

A0KEQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLGQNISRA ILQWPVSGLV NHKSLPENPI TELKLDPARP IVYALKTSSI
60 70 80 90 100
TDLMTLQQCC EDLGLPGPFT PLELNGQLLP RYVCLDRPPP LFGKRSKPLP
110 120 130 140 150
FLQEFHQLLD LHKQDPALDI QVVPVTLFWG RAPGREGEEA SGWNIISSLA
160 170 180 190 200
PNRLKKALIV ILKGRENLVR FSPPLSLRHM ADKHGTDEAI AHKLARVART
210 220 230 240 250
HFSRQQLAAT GPKLPNRNLL FKQLLDSNVI QQAIEEEAQR EGISLEKAQK
260 270 280 290 300
RAHGYMDEIA SDFSYRLIRL GESFLGWLWN KLYRGLSVNG AEKVRQLAQE
310 320 330 340 350
GHEIVYVPCH RSHMDYLLLS YVIYHQGMVP PHIAAGINLN FWPAGPIFRH
360 370 380 390 400
GGAFFIRRTF KGNPLYSTVF REYLNLLFAK GYSVEFFTEG GRSRTGRLLP
410 420 430 440 450
PKTGMLAMTL QAMMRGLDRP VTLVPVYLGY EHVMEVNTYH NELKGSRKEK
460 470 480 490 500
ESFLQVLGIL RKLRNYGRGF VNFGEPLTLN NYLNEHVPSW KEHIGEEERP
510 520 530 540 550
EWMAPTVNQL AELLMTRING AAAVNGLTLS ALALLAAERH ALTRDELQAQ
560 570 580 590 600
LNTYLDLLKQ VPYSPHSTIP DEDAKTLLDQ AMELNKFEVS EDKLGQIVSL
610 620 630 640 650
DRYQAILLTY YRNNILHLFA MPSLVAALIE RCEGISRSEI VARCIDIYPL
660 670 680 690 700
LKTELFLRYE EDELPELVDA LLAELQRQQL IEARDGGFWV NPVNQTRLLL
710 720 730 740 750
LAESIQETLQ RYAIVLTRVL AQPRIEAEQL EADGLMMAER LGTLHGINAP
760 770 780 790 800
EFFDQKLFST LIHTLRSEGY LDPGCKPDLG RFQALADNIV PLLSTKIRRT

IQAGNRL
Length:807
Mass (Da):91,472
Last modified:December 12, 2006 - v1
Checksum:i030E2B3C2CCC210E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000462 Genomic DNA Translation: ABK36673.1
RefSeqiWP_011704200.1, NC_008570.1
YP_854715.1, NC_008570.1

Genome annotation databases

EnsemblBacteriaiABK36673; ABK36673; AHA_0182
GeneIDi4486812
KEGGiaha:AHA_0182
PATRICifig|380703.7.peg.173

Similar proteinsi

Entry informationi

Entry nameiPLSB_AERHH
AccessioniPrimary (citable) accession number: A0KEQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: June 20, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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