A0KEP8 (UBIC_AERHH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable chorismate--pyruvate lyase
Short name=CL
Short name=CPL
EC=4.1.3.40

Gene names

Name:	ubiC
Ordered Locus Names:	AHA_0180

Organism

Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) [Complete proteome] [HAMAP]

Taxonomic identifier

380703 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length	178 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway By similarity. HAMAP MF_01632
Catalytic activity	Chorismate = 4-hydroxybenzoate + pyruvate. HAMAP MF_01632
Pathway	Cofactor biosynthesis; ubiquinone biosynthesis. HAMAP MF_01632
Subcellular location	Cytoplasm By similarity HAMAP MF_01632.
Sequence similarities	Belongs to the ubiC family.

Ontologies

Keywords
Biological process	Ubiquinone biosynthesis
Cellular component	Cytoplasm
Ligand	Pyruvate
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ubiquinone biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	chorismate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 178	178	Probable chorismate--pyruvate lyase HAMAP MF_01632		PRO_1000069740
Sites
	Binding site	37	1	Substrate; via amide nitrogen By similarity
	Binding site	78	1	Substrate By similarity
	Binding site	114	1	Substrate; via amide nitrogen By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0KEP8 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 7BD810730997C01E	FASTA	178	20,132
	10 20 30 40 50 60 MKSELTVPLA RLVPWQTPAQ CEPPEALLPW LLEADSMTRR LRRHNRHFSV QLFGNRSVAL 70 80 90 100 110 120 DADEQQLVVA EQPMGLCREV ILHGDHGPAV LGWTLFAEAA LQESGLRELG EQPLGERIFG 130 140 150 160 170 DEPARRDHLQ LACFEIASNP WCPAGTVWGR RSRLFLGQWP LLVHELFLPS LSCNKELE

References

[1]

"Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades." Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.H., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F. J. Bacteriol. 188:8272-8282(2006) [PubMed: 16980456] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 7966 / NCIB 9240.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000462 Genomic DNA. Translation: ABK37637.1.
RefSeq	YP_854713.1. NC_008570.1.
3D structure databases
ProteinModelPortal	A0KEP8.
ModBase	Search...
Protein-protein interaction databases
STRING	A0KEP8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4486810.
GenomeReviews	Gene locus AHA_0180 in contig CP000462_GR.
KEGG	aha:AHA_0180.
PATRIC	20777828. VBIAerHyd135212_0171.
TIGR	AHA_0180.
Phylogenomic databases
eggNOG	COG3161.
HOGENOM	HBG644467.
OMA	LQITHTH.
ProtClustDB	CLSK729363.
Enzyme and pathway databases
BioCyc	AHYD196024:AHA_0180-MONOMER.
Family and domain databases
HAMAP	MF_01632. UbiC. [Tree]
InterPro	IPR007440. Chorismate--pyruvate_lyase. [Graphical view]
KO	K03181.
Pfam	PF04345. Chor_lyase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UBIC_AERHH

Accession

Primary (citable) accession number: A0KEP8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	December 12, 2006
Last modified:	December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program