Reviewed, UniProtKB/Swiss-Prot A0KEM2 (G6PI_AERHH)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate isomerase
      Short name=GPI
    EC=5.3.1.9
Alternative name(s):
    Phosphoglucose isomerase
      Short name=PGI
    Phosphohexose isomerase
      Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	AHA_0154

Organism

Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) [Complete proteome] [HAMAP]

Taxonomic identifier

380703 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length	549 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: HAMAP glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 549	549	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_1000013937
Sites
	Active site	355	1	Proton donor By similarity
	Active site	386	1	By similarity
	Active site	514	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0KEM2-1 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 4B92705D5DBBA948	FASTA	549	61,277
	10 20 30 40 50 60 MKNINPTQTQ AWQALEAHFA ANKETRLKDL FAQDPKRFDK FSLTFGGDIL VDYSKNLITE 70 80 90 100 110 120 ETLKLLVDLA KETDLRSAID AMFNGDKINM TEGRSVLHVA LRNRSDRPIE CDGKDVMPEV 130 140 150 160 170 180 NAVLAKMKGF CEKIISGEWK GYTGKAIQHV VNIGIGGSDL GPVMITEALR PYKNHLQMHF 190 200 210 220 230 240 VSNVDGTHIA ETLKKIDPET TLFLVASKTF TTQETMTNAL TARDWFIKIA GDKAHVAKHF 250 260 270 280 290 300 AALSTNGKAV AEFGIDTNNM FEFWDWVGGR YSSWSAIGMP IALSVGFENF EALLQGAFEM 310 320 330 340 350 360 DMHFATASYE QNVPVLLALI GLWYNNFYGA ESEAILPYDQ YMHRFPAYFQ QGNMESNGKY 370 380 390 400 410 420 VDRNGKPVDY QTGPIIWGEP GTNGQHAFYQ LIHQGTKLIP CDFLAPAISH NPIGDHHPKL 430 440 450 460 470 480 LANFFAQTEA LAFGKSKEQV EAEFLAAGKT LEQVKDLVPF KVFEGNRPTN SILFKSLTPK 490 500 510 520 530 540 TLGALIAMYE HKIFVQGAIW NIFSFDQWGV ELGKQLANKI LPELNTDAAV TSHDCSTNGL INTWKAWKA

References

[1]

"Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades." Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.H., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F. J. Bacteriol. 188:8272-8282(2006) [PubMed: 16980456] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000462 Genomic DNA. Translation: ABK39217.1.
RefSeq	YP_854687.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A0KEM2.
Genome annotation databases
GeneID	4490335.
GenomeReviews	Gene locus AHA_0154 in contig CP000462_GR.
KEGG	aha:AHA_0154.
TIGR	AHA_0154.
Phylogenomic databases
OMA	GPKIVSQ.
Family and domain databases
HAMAP	MF_00473. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_AERHH

Accession

Primary (citable) accession number: A0KEM2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	December 12, 2006
Last modified:	November 3, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)