A0KEJ0 (NORR_AERHH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anaerobic nitric oxide reductase transcription regulator NorR

Gene names

Name:	norR
Ordered Locus Names:	AHA_0118

Organism

Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) [Complete proteome] [HAMAP]

Taxonomic identifier

380703 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas › Aeromonas hydrophila › Aeromonas hydrophila subsp. hydrophila

Protein attributes

Sequence length	508 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54 By similarity. HAMAP-Rule MF_01314
Pathway	Nitrogen metabolism; nitric oxide reduction. HAMAP-Rule MF_01314
Sequence similarities	Contains 1 sigma-54 factor interaction domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	ATP-binding DNA-binding Nucleotide-binding
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	phosphorelay signal transduction system Inferred from electronic annotation. Source: HAMAP sensory perception Inferred from electronic annotation. Source: HAMAP transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 508	508	Anaerobic nitric oxide reductase transcription regulator NorR HAMAP-Rule MF_01314		PRO_0000305616
Regions
	Domain	186 – 415	230	Sigma-54 factor interaction
	Nucleotide binding	214 – 221	8	ATP Potential
	Nucleotide binding	277 – 286	10	ATP Potential
	DNA binding	483 – 502	20	H-T-H motif By similarity
Amino acid modifications
	Modified residue	56	1	4-aspartylphosphate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0KEJ0 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: A53D06D5653CFFD9	FASTA	508	55,065
	10 20 30 40 50 60 MISTDSLARI ALDLQLGISH QDRFHRLIQS VRSLLNSDAS ALLRYEGGQF IPLAIDGLMQ 70 80 90 100 110 120 DVLGRRFALK DHPRMEAIAR AGDVVRFPAD SSLPDPYDGL LPDHDDFKVH ACVGLPLFSD 130 140 150 160 170 180 QALIGALTID GMNPTQFDAI SDEELRLVGA LAAAALNNAL LLERLARQSS EPLVPGTRPG 190 200 210 220 230 240 PEQPEMIGQS PAMARLRHEI EVVANSELNV LILGETGVGK ELIAKAVHRG SQRAKAPLVY 250 260 270 280 290 300 LNCAALPESV AESELFGHVK GAFTGAIHNR AGKFELADQG TLFLDEIGEL SLPLQAKLLR 310 320 330 340 350 360 VLQYGDLQRI GDDTPLKVNV RILAATNRDL KQAVVEGQFR ADLYHRLSVF PIHAPALRER 370 380 390 400 410 420 PGDIPLLAGY FCERCRLSLG LEQLRIQPQA LQLLERHDWP GNVRELEHAI HRAAVLARAE 430 440 450 460 470 480 QGSQTPTLAS HHFNLAAGPL PPSTSPAMAP MTPLPGGLGL RAATDAFQLA LIEQTLAAHN 490 500 GNWAATARAL ELDSGNLHRL AKRLGLKA

References

[1]

"Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades." Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.H., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F. J. Bacteriol. 188:8272-8282(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 7966 / NCIB 9240.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000462 Genomic DNA. Translation: ABK35919.1.
RefSeq	YP_854649.1. NC_008570.1.
3D structure databases
ProteinModelPortal	A0KEJ0.
ModBase	Search...
Protein-protein interaction databases
STRING	380703.AHA_0118.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABK35919; ABK35919; AHA_0118.
GeneID	4487498.
KEGG	aha:AHA_0118.
PATRIC	20777700. VBIAerHyd135212_0111.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3604.
HOGENOM	HOG000058487.
KO	K12266.
OMA	DSEAKMS.
ProtClustDB	PRK05022.
Enzyme and pathway databases
BioCyc	AHYD380703:GH2M-269-MONOMER.
UniPathway	UPA00638.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
HAMAP	MF_01314. NorR.
InterPro	IPR003593. AAA+_ATPase. IPR003018. GAF. IPR009057. Homeodomain-like. IPR023944. NorR. IPR002078. Sigma_54_int. IPR025662. Sigma_54_int_dom_ATP-bd_1. IPR025944. Sigma_54_int_dom_CS. [Graphical view]
Pfam	PF13185. GAF_2. 1 hit. PF00158. Sigma54_activat. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. SM00065. GAF. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00675. SIGMA54_INTERACT_1. 1 hit. PS00676. SIGMA54_INTERACT_2. False negative. PS00688. SIGMA54_INTERACT_3. 1 hit. PS50045. SIGMA54_INTERACT_4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NORR_AERHH

Accession

Primary (citable) accession number: A0KEJ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	December 12, 2006
Last modified:	May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program