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Protein

Anaerobic nitric oxide reductase transcription regulator NorR

Gene

norR

Organism
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54.UniRule annotation

Pathway:initric oxide reduction

This protein is involved in the pathway nitric oxide reduction, which is part of Nitrogen metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway nitric oxide reduction and in Nitrogen metabolism.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi214 – 2218ATPUniRule annotation
Nucleotide bindingi277 – 28610ATPUniRule annotation
DNA bindingi483 – 50220H-T-H motifUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAHYD380703:GH2M-118-MONOMER.
UniPathwayiUPA00638.

Names & Taxonomyi

Protein namesi
Recommended name:
Anaerobic nitric oxide reductase transcription regulator NorRUniRule annotation
Gene namesi
Name:norRUniRule annotation
Ordered Locus Names:AHA_0118
OrganismiAeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240)
Taxonomic identifieri380703 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas
ProteomesiUP000000756 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508Anaerobic nitric oxide reductase transcription regulator NorRPRO_0000305616Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei56 – 5614-aspartylphosphateUniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi380703.AHA_0118.

Structurei

3D structure databases

ProteinModelPortaliA0KEJ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini186 – 415230Sigma-54 factor interactionUniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 sigma-54 factor interaction domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG3604.
HOGENOMiHOG000058487.
KOiK12266.
OMAiVHSCIGL.
OrthoDBiEOG6WHNMG.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
3.30.450.40. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01314. NorR.
InterProiIPR003593. AAA+_ATPase.
IPR003018. GAF.
IPR029016. GAF_dom-like.
IPR009057. Homeodomain-like.
IPR023944. NorR.
IPR027417. P-loop_NTPase.
IPR002078. Sigma_54_int.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR025944. Sigma_54_int_dom_CS.
[Graphical view]
PfamiPF01590. GAF. 1 hit.
PF00158. Sigma54_activat. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00065. GAF. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF55781. SSF55781. 1 hit.
PROSITEiPS00675. SIGMA54_INTERACT_1. 1 hit.
PS00688. SIGMA54_INTERACT_3. 1 hit.
PS50045. SIGMA54_INTERACT_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0KEJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISTDSLARI ALDLQLGISH QDRFHRLIQS VRSLLNSDAS ALLRYEGGQF
60 70 80 90 100
IPLAIDGLMQ DVLGRRFALK DHPRMEAIAR AGDVVRFPAD SSLPDPYDGL
110 120 130 140 150
LPDHDDFKVH ACVGLPLFSD QALIGALTID GMNPTQFDAI SDEELRLVGA
160 170 180 190 200
LAAAALNNAL LLERLARQSS EPLVPGTRPG PEQPEMIGQS PAMARLRHEI
210 220 230 240 250
EVVANSELNV LILGETGVGK ELIAKAVHRG SQRAKAPLVY LNCAALPESV
260 270 280 290 300
AESELFGHVK GAFTGAIHNR AGKFELADQG TLFLDEIGEL SLPLQAKLLR
310 320 330 340 350
VLQYGDLQRI GDDTPLKVNV RILAATNRDL KQAVVEGQFR ADLYHRLSVF
360 370 380 390 400
PIHAPALRER PGDIPLLAGY FCERCRLSLG LEQLRIQPQA LQLLERHDWP
410 420 430 440 450
GNVRELEHAI HRAAVLARAE QGSQTPTLAS HHFNLAAGPL PPSTSPAMAP
460 470 480 490 500
MTPLPGGLGL RAATDAFQLA LIEQTLAAHN GNWAATARAL ELDSGNLHRL

AKRLGLKA
Length:508
Mass (Da):55,065
Last modified:December 12, 2006 - v1
Checksum:iA53D06D5653CFFD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000462 Genomic DNA. Translation: ABK35919.1.
RefSeqiWP_011704146.1. NC_008570.1.
YP_854649.1. NC_008570.1.

Genome annotation databases

EnsemblBacteriaiABK35919; ABK35919; AHA_0118.
GeneIDi4487498.
KEGGiaha:AHA_0118.
PATRICi20777700. VBIAerHyd135212_0111.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000462 Genomic DNA. Translation: ABK35919.1.
RefSeqiWP_011704146.1. NC_008570.1.
YP_854649.1. NC_008570.1.

3D structure databases

ProteinModelPortaliA0KEJ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi380703.AHA_0118.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK35919; ABK35919; AHA_0118.
GeneIDi4487498.
KEGGiaha:AHA_0118.
PATRICi20777700. VBIAerHyd135212_0111.

Phylogenomic databases

eggNOGiCOG3604.
HOGENOMiHOG000058487.
KOiK12266.
OMAiVHSCIGL.
OrthoDBiEOG6WHNMG.

Enzyme and pathway databases

UniPathwayiUPA00638.
BioCyciAHYD380703:GH2M-118-MONOMER.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
3.30.450.40. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01314. NorR.
InterProiIPR003593. AAA+_ATPase.
IPR003018. GAF.
IPR029016. GAF_dom-like.
IPR009057. Homeodomain-like.
IPR023944. NorR.
IPR027417. P-loop_NTPase.
IPR002078. Sigma_54_int.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR025944. Sigma_54_int_dom_CS.
[Graphical view]
PfamiPF01590. GAF. 1 hit.
PF00158. Sigma54_activat. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00065. GAF. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF55781. SSF55781. 1 hit.
PROSITEiPS00675. SIGMA54_INTERACT_1. 1 hit.
PS00688. SIGMA54_INTERACT_3. 1 hit.
PS50045. SIGMA54_INTERACT_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240.

Entry informationi

Entry nameiNORR_AERHH
AccessioniPrimary (citable) accession number: A0KEJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 12, 2006
Last modified: July 22, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.