ID   GPPA_AERHH              Reviewed;         496 AA.
AC   A0KEG8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   16-JUN-2009, entry version 15.
DE   RecName: Full=Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase;
DE            EC=3.6.1.40;
DE   AltName: Full=Guanosine pentaphosphate phosphohydrolase;
DE   AltName: Full=pppGpp-5'-phosphohydrolase;
GN   Name=gppA; OrderedLocusNames=AHA_0096;
OS   Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=380703;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16980456; DOI=10.1128/JB.00621-06;
RA   Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J.,
RA   Haft D.H., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M.,
RA   Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
RT   "Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all
RT   trades.";
RL   J. Bacteriol. 188:8272-8282(2006).
CC   -!- FUNCTION: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate
CC       (pppGpp) is a cytoplasmic signaling molecule which together with
CC       ppGpp controls the "stringent response", an adaptive process that
CC       allows bacteria to respond to amino acid starvation, resulting in
CC       the coordinated regulation of numerous cellular activities (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: Guanosine 5'-triphosphate,3'-diphosphate +
CC       H(2)O = guanosine 5'-diphosphate,3'-diphosphate + phosphate.
CC   -!- PATHWAY: Purine metabolism; ppGpp biosynthesis; ppGpp from GTP:
CC       step 1/2.
CC   -!- SIMILARITY: Belongs to the gppA/ppx family. GppA subfamily.
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DR   EMBL; CP000462; ABK39541.1; -; Genomic_DNA.
DR   RefSeq; YP_854621.1; -.
DR   GeneID; 4490991; -.
DR   GenomeReviews; CP000462_GR; AHA_0096.
DR   KEGG; aha:AHA_0096; -.
DR   TIGR; AHA_0096; -.
DR   OMA; A0KEG8; ANRRRND.
DR   GO; GO:0008894; F:guanosine-5'-triphosphate,3'-diphosphate di...; IEA:HAMAP.
DR   HAMAP; MF_01550; -; 1.
DR   InterPro; IPR003695; Ppx_GppA.
DR   Pfam; PF02541; Ppx-GppA; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase.
FT   CHAIN         1    496       Guanosine-5'-triphosphate,3'-diphosphate
FT                                pyrophosphatase.
FT                                /FTId=PRO_0000314491.
SQ   SEQUENCE   496 AA;  55133 MW;  3166C56CE0D4D7B0 CRC64;
     MHNSPLYAAI DLGSNSFHML VVREVAGALR TVTKVKRKVR LAAGLDPEFR LSRAAMERGW
     DCLRLFSEQL QDIPADNIRV VGTATLRLAT NVDEFLSEAE RVLNHSIEII SGEEEAKTIY
     EGVSWTSAGE GNRLVIDIGG ASTELVIGEH SEAKLLNSLH MGCVTWLNNH FGDGELSEAR
     FKQAIAAAKA VLEKVAEDYR ALGWRTCVGA SGTVQALQEI MLAQGKSERV TLPKLQELMG
     QAIACGKLDQ LQLEGLAAER LTVFPSGLAI LIAIFETLGI ESMTLAGGAL REGLIYGLLG
     NNHDCDARDR TADSLINRYQ LDKEHAERVR DTAVEAFNQL QPAWRLSKRY GRPILRYAAL
     LHEIGLCIEY KKAPQHAAYI IDNIDMPGFT PAQKKLLSAL LFNQRDEFKL EPLEKQGAVT
     GRQAIRLARI LRIALILCMR RTQGTVPRFT LEADEDALTL TLPSGWLDEH YLRASELRFE
     VERQQKMGWP TRLLEA
//