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A0KEG8

- GPPA_AERHH

UniProt

A0KEG8 - GPPA_AERHH

Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

    Catalytic activityi

    Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: InterPro
    3. phosphoric diester hydrolase activity Source: InterPro

    GO - Biological processi

    1. guanosine pentaphosphate catabolic process Source: InterPro
    2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciAHYD380703:GH2M-96-MONOMER.
    UniPathwayiUPA00908; UER00884.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
    Alternative name(s):
    Guanosine pentaphosphate phosphohydrolaseUniRule annotation
    pppGpp-5'-phosphohydrolaseUniRule annotation
    Gene namesi
    Name:gppAUniRule annotation
    Ordered Locus Names:AHA_0096
    OrganismiAeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
    Taxonomic identifieri380703 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas
    ProteomesiUP000000756: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 496496Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_0000314491Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi380703.AHA_0096.

    Structurei

    3D structure databases

    ProteinModelPortaliA0KEG8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0248.
    HOGENOMiHOG000258672.
    KOiK01524.
    OMAiGLHIEYK.
    OrthoDBiEOG6M6JN6.

    Family and domain databases

    Gene3Di1.10.3210.10. 1 hit.
    HAMAPiMF_01550. GppA.
    InterProiIPR023709. Guo-5TP_3DP_PyrP.
    IPR006674. HD_domain.
    IPR003695. Ppx_GppA.
    [Graphical view]
    PfamiPF02541. Ppx-GppA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0KEG8-1 [UniParc]FASTAAdd to Basket

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    MHNSPLYAAI DLGSNSFHML VVREVAGALR TVTKVKRKVR LAAGLDPEFR    50
    LSRAAMERGW DCLRLFSEQL QDIPADNIRV VGTATLRLAT NVDEFLSEAE 100
    RVLNHSIEII SGEEEAKTIY EGVSWTSAGE GNRLVIDIGG ASTELVIGEH 150
    SEAKLLNSLH MGCVTWLNNH FGDGELSEAR FKQAIAAAKA VLEKVAEDYR 200
    ALGWRTCVGA SGTVQALQEI MLAQGKSERV TLPKLQELMG QAIACGKLDQ 250
    LQLEGLAAER LTVFPSGLAI LIAIFETLGI ESMTLAGGAL REGLIYGLLG 300
    NNHDCDARDR TADSLINRYQ LDKEHAERVR DTAVEAFNQL QPAWRLSKRY 350
    GRPILRYAAL LHEIGLCIEY KKAPQHAAYI IDNIDMPGFT PAQKKLLSAL 400
    LFNQRDEFKL EPLEKQGAVT GRQAIRLARI LRIALILCMR RTQGTVPRFT 450
    LEADEDALTL TLPSGWLDEH YLRASELRFE VERQQKMGWP TRLLEA 496
    Length:496
    Mass (Da):55,133
    Last modified:December 12, 2006 - v1
    Checksum:i3166C56CE0D4D7B0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000462 Genomic DNA. Translation: ABK39541.1.
    RefSeqiYP_854621.1. NC_008570.1.

    Genome annotation databases

    EnsemblBacteriaiABK39541; ABK39541; AHA_0096.
    GeneIDi4490991.
    KEGGiaha:AHA_0096.
    PATRICi20777654. VBIAerHyd135212_0088.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000462 Genomic DNA. Translation: ABK39541.1 .
    RefSeqi YP_854621.1. NC_008570.1.

    3D structure databases

    ProteinModelPortali A0KEG8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 380703.AHA_0096.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK39541 ; ABK39541 ; AHA_0096 .
    GeneIDi 4490991.
    KEGGi aha:AHA_0096.
    PATRICi 20777654. VBIAerHyd135212_0088.

    Phylogenomic databases

    eggNOGi COG0248.
    HOGENOMi HOG000258672.
    KOi K01524.
    OMAi GLHIEYK.
    OrthoDBi EOG6M6JN6.

    Enzyme and pathway databases

    UniPathwayi UPA00908 ; UER00884 .
    BioCyci AHYD380703:GH2M-96-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3210.10. 1 hit.
    HAMAPi MF_01550. GppA.
    InterProi IPR023709. Guo-5TP_3DP_PyrP.
    IPR006674. HD_domain.
    IPR003695. Ppx_GppA.
    [Graphical view ]
    Pfami PF02541. Ppx-GppA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 7966 / NCIB 9240.

    Entry informationi

    Entry nameiGPPA_AERHH
    AccessioniPrimary (citable) accession number: A0KEG8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3