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A0KEG8

- GPPA_AERHH

UniProt

A0KEG8 - GPPA_AERHH

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Protein
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase
Gene
gppA, AHA_0096
Organism
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: InterPro
  3. phosphoric diester hydrolase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. guanosine pentaphosphate catabolic process Source: InterPro
  2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciAHYD380703:GH2M-96-MONOMER.
UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (EC:3.6.1.40)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene namesi
Name:gppA
Ordered Locus Names:AHA_0096
OrganismiAeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
Taxonomic identifieri380703 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas
ProteomesiUP000000756: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation
PRO_0000314491Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi380703.AHA_0096.

Structurei

3D structure databases

ProteinModelPortaliA0KEG8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
KOiK01524.
OMAiGLHIEYK.
OrthoDBiEOG6M6JN6.

Family and domain databases

Gene3Di1.10.3210.10. 1 hit.
HAMAPiMF_01550. GppA.
InterProiIPR023709. Guo-5TP_3DP_PyrP.
IPR006674. HD_domain.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0KEG8-1 [UniParc]FASTAAdd to Basket

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MHNSPLYAAI DLGSNSFHML VVREVAGALR TVTKVKRKVR LAAGLDPEFR    50
LSRAAMERGW DCLRLFSEQL QDIPADNIRV VGTATLRLAT NVDEFLSEAE 100
RVLNHSIEII SGEEEAKTIY EGVSWTSAGE GNRLVIDIGG ASTELVIGEH 150
SEAKLLNSLH MGCVTWLNNH FGDGELSEAR FKQAIAAAKA VLEKVAEDYR 200
ALGWRTCVGA SGTVQALQEI MLAQGKSERV TLPKLQELMG QAIACGKLDQ 250
LQLEGLAAER LTVFPSGLAI LIAIFETLGI ESMTLAGGAL REGLIYGLLG 300
NNHDCDARDR TADSLINRYQ LDKEHAERVR DTAVEAFNQL QPAWRLSKRY 350
GRPILRYAAL LHEIGLCIEY KKAPQHAAYI IDNIDMPGFT PAQKKLLSAL 400
LFNQRDEFKL EPLEKQGAVT GRQAIRLARI LRIALILCMR RTQGTVPRFT 450
LEADEDALTL TLPSGWLDEH YLRASELRFE VERQQKMGWP TRLLEA 496
Length:496
Mass (Da):55,133
Last modified:December 12, 2006 - v1
Checksum:i3166C56CE0D4D7B0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000462 Genomic DNA. Translation: ABK39541.1.
RefSeqiYP_854621.1. NC_008570.1.

Genome annotation databases

EnsemblBacteriaiABK39541; ABK39541; AHA_0096.
GeneIDi4490991.
KEGGiaha:AHA_0096.
PATRICi20777654. VBIAerHyd135212_0088.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000462 Genomic DNA. Translation: ABK39541.1 .
RefSeqi YP_854621.1. NC_008570.1.

3D structure databases

ProteinModelPortali A0KEG8.
ModBasei Search...

Protein-protein interaction databases

STRINGi 380703.AHA_0096.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK39541 ; ABK39541 ; AHA_0096 .
GeneIDi 4490991.
KEGGi aha:AHA_0096.
PATRICi 20777654. VBIAerHyd135212_0088.

Phylogenomic databases

eggNOGi COG0248.
HOGENOMi HOG000258672.
KOi K01524.
OMAi GLHIEYK.
OrthoDBi EOG6M6JN6.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .
BioCyci AHYD380703:GH2M-96-MONOMER.

Family and domain databases

Gene3Di 1.10.3210.10. 1 hit.
HAMAPi MF_01550. GppA.
InterProi IPR023709. Guo-5TP_3DP_PyrP.
IPR006674. HD_domain.
IPR003695. Ppx_GppA.
[Graphical view ]
Pfami PF02541. Ppx-GppA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 7966 / NCIB 9240.

Entry informationi

Entry nameiGPPA_AERHH
AccessioniPrimary (citable) accession number: A0KEG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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