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A0KEG8

- GPPA_AERHH

UniProt

A0KEG8 - GPPA_AERHH

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Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. guanosine pentaphosphate catabolic process Source: InterPro
  2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciAHYD380703:GH2M-96-MONOMER.
UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolaseUniRule annotation
pppGpp-5'-phosphohydrolaseUniRule annotation
Gene namesi
Name:gppAUniRule annotation
Ordered Locus Names:AHA_0096
OrganismiAeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
Taxonomic identifieri380703 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas
ProteomesiUP000000756: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_0000314491Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi380703.AHA_0096.

Structurei

3D structure databases

ProteinModelPortaliA0KEG8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
KOiK01524.
OMAiGLHIEYK.
OrthoDBiEOG6M6JN6.

Family and domain databases

Gene3Di1.10.3210.10. 1 hit.
HAMAPiMF_01550. GppA.
InterProiIPR023709. Guo-5TP_3DP_PyrP.
IPR006674. HD_domain.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0KEG8 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHNSPLYAAI DLGSNSFHML VVREVAGALR TVTKVKRKVR LAAGLDPEFR
60 70 80 90 100
LSRAAMERGW DCLRLFSEQL QDIPADNIRV VGTATLRLAT NVDEFLSEAE
110 120 130 140 150
RVLNHSIEII SGEEEAKTIY EGVSWTSAGE GNRLVIDIGG ASTELVIGEH
160 170 180 190 200
SEAKLLNSLH MGCVTWLNNH FGDGELSEAR FKQAIAAAKA VLEKVAEDYR
210 220 230 240 250
ALGWRTCVGA SGTVQALQEI MLAQGKSERV TLPKLQELMG QAIACGKLDQ
260 270 280 290 300
LQLEGLAAER LTVFPSGLAI LIAIFETLGI ESMTLAGGAL REGLIYGLLG
310 320 330 340 350
NNHDCDARDR TADSLINRYQ LDKEHAERVR DTAVEAFNQL QPAWRLSKRY
360 370 380 390 400
GRPILRYAAL LHEIGLCIEY KKAPQHAAYI IDNIDMPGFT PAQKKLLSAL
410 420 430 440 450
LFNQRDEFKL EPLEKQGAVT GRQAIRLARI LRIALILCMR RTQGTVPRFT
460 470 480 490
LEADEDALTL TLPSGWLDEH YLRASELRFE VERQQKMGWP TRLLEA
Length:496
Mass (Da):55,133
Last modified:December 12, 2006 - v1
Checksum:i3166C56CE0D4D7B0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000462 Genomic DNA. Translation: ABK39541.1.
RefSeqiYP_854621.1. NC_008570.1.

Genome annotation databases

EnsemblBacteriaiABK39541; ABK39541; AHA_0096.
GeneIDi4490991.
KEGGiaha:AHA_0096.
PATRICi20777654. VBIAerHyd135212_0088.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000462 Genomic DNA. Translation: ABK39541.1 .
RefSeqi YP_854621.1. NC_008570.1.

3D structure databases

ProteinModelPortali A0KEG8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 380703.AHA_0096.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK39541 ; ABK39541 ; AHA_0096 .
GeneIDi 4490991.
KEGGi aha:AHA_0096.
PATRICi 20777654. VBIAerHyd135212_0088.

Phylogenomic databases

eggNOGi COG0248.
HOGENOMi HOG000258672.
KOi K01524.
OMAi GLHIEYK.
OrthoDBi EOG6M6JN6.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .
BioCyci AHYD380703:GH2M-96-MONOMER.

Family and domain databases

Gene3Di 1.10.3210.10. 1 hit.
HAMAPi MF_01550. GppA.
InterProi IPR023709. Guo-5TP_3DP_PyrP.
IPR006674. HD_domain.
IPR003695. Ppx_GppA.
[Graphical view ]
Pfami PF02541. Ppx-GppA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 7966 / NCIB 9240.

Entry informationi

Entry nameiGPPA_AERHH
AccessioniPrimary (citable) accession number: A0KEG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3