A0KE56 (XYLA_BURCH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Xylose isomerase
EC=5.3.1.5

Gene names

Name:	xylA
Ordered Locus Names:	Bcen2424_6740

Organism

Burkholderia cenocepacia (strain HI2424) [Complete proteome] [HAMAP]

Taxonomic identifier

331272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	440 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-xylose = D-xylulose. HAMAP MF_00455
Cofactor	Binds 2 magnesium ions per subunit By similarity. HAMAP MF_00455
Subunit structure	Homotetramer By similarity. HAMAP MF_00455
Subcellular location	Cytoplasm By similarity HAMAP MF_00455.
Sequence similarities	Belongs to the xylose isomerase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Pentose shunt Xylose metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	D-xylose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW pentose-phosphate shunt Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW xylose isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 440	440	Xylose isomerase HAMAP MF_00455		PRO_1000026434
Sites
	Active site	100	1	By similarity
	Active site	103	1	By similarity
	Metal binding	231	1	Magnesium 1 By similarity
	Metal binding	267	1	Magnesium 1 By similarity
	Metal binding	267	1	Magnesium 2 By similarity
	Metal binding	270	1	Magnesium 2 By similarity
	Metal binding	295	1	Magnesium 1 By similarity
	Metal binding	306	1	Magnesium 2 By similarity
	Metal binding	308	1	Magnesium 2 By similarity
	Metal binding	338	1	Magnesium 1 By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0KE56 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 84C3C1B2B707A885	FASTA	440	49,524
	10 20 30 40 50 60 MSYFEHIPAI RYEGPQSDNP LAYHHYDPDK RVLGKTLAEH LRIAVCYWHT FVWPGHDIFG 70 80 90 100 110 120 QGAFQRPWQQ PGDALERARQ KADAAFEFFT KLGTPFYTFH DTDVAPEGDS LRDYAANFAR 130 140 150 160 170 180 MVDYLGERQQ ASGVRLLWGT ANLFSHPRFA AGAATNPNPD VFAWAATQVC HALDATHRLG 190 200 210 220 230 240 GENYVLWGGR EGYETLLNTD LKRERDQFAR FLSMVVEHKH RIGFKGALLI EPKPQEPTKH 250 260 270 280 290 300 QYDYDVATVH GFLVQYGLQN EIRVNIEANH ATLAGHSFHH EIANAFALGV FGSVDANRGD 310 320 330 340 350 360 PQNGWDTDQF PNSVEELTLA FYEILRHGGF TTGGMNFDAK VRRQSIDPED LFYGHVGAID 370 380 390 400 410 420 VLALALERAA VLVENDRLDA LRRQRYAQWD DAFGRKILSG GYTLESLAAD ALARGVNPRH 430 440 ASGAQERLEN IVNQAIYGLR

References

[1]

"Complete sequence of chromosome 3 of Burkholderia cenocepacia HI2424." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., LiPuma J.J., Gonzalez C.F., Konstantinidis K., Tiedje J.M., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HI2424.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000460 Genomic DNA. Translation: ABK13469.1.
RefSeq	YP_840362.1. NC_008544.1.
3D structure databases
ProteinModelPortal	A0KE56.
SMR	A0KE56. Positions 2-438.
ModBase	Search...
Protein-protein interaction databases
STRING	A0KE56.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4453877.
GenomeReviews	Gene locus Bcen2424_6740 in contig CP000460_GR.
KEGG	bch:Bcen2424_6740.
PATRIC	19071226. VBIBurCen15205_6923.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2115.
HOGENOM	HBG297199.
OMA	LLGWDTD.
ProtClustDB	PRK05474.
Enzyme and pathway databases
BioCyc	BCEN331272:BCEN2424_6740-MONOMER.
Family and domain databases
HAMAP	MF_00455. Xylose_isom_A. [Tree]
InterPro	IPR013022. Xyl_isomerase-like_TIM-brl. IPR012307. Xyl_isomerase_TIM-brl. IPR013452. Xylose_isom_bac. IPR001998. Xylose_isomerase. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
KO	K01805.
Pfam	PF01261. AP_endonuc_2. 1 hit. [Graphical view]
PRINTS	PR00688. XYLOSISMRASE.
SUPFAM	SSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMs	TIGR02630. Xylose_isom_A. 1 hit.
PROSITE	PS51415. XYLOSE_ISOMERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

XYLA_BURCH

Accession

Primary (citable) accession number: A0KE56

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	December 12, 2006
Last modified:	December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program