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A0KCQ9

- TYPH_BURCH

UniProt

A0KCQ9 - TYPH_BURCH

Protein

Thymidine phosphorylase

Gene

deoA

Organism
Burkholderia cenocepacia (strain HI2424)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.UniRule annotation

    Catalytic activityi

    Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. phosphorylase activity Source: InterPro
    2. pyrimidine-nucleoside phosphorylase activity Source: InterPro
    3. thymidine phosphorylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pyrimidine nucleobase metabolic process Source: InterPro
    2. pyrimidine nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciBCEN331272:GHR7-6325-MONOMER.
    UniPathwayiUPA00578; UER00638.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine phosphorylaseUniRule annotation (EC:2.4.2.4UniRule annotation)
    Alternative name(s):
    TdRPaseUniRule annotation
    Gene namesi
    Name:deoAUniRule annotation
    Ordered Locus Names:Bcen2424_6240
    OrganismiBurkholderia cenocepacia (strain HI2424)
    Taxonomic identifieri331272 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
    ProteomesiUP000000776: Chromosome 3

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 438438Thymidine phosphorylasePRO_0000335771Add
    BLAST

    Proteomic databases

    PRIDEiA0KCQ9.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi331272.Bcen2424_6240.

    Structurei

    3D structure databases

    ProteinModelPortaliA0KCQ9.
    SMRiA0KCQ9. Positions 1-437.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0213.
    HOGENOMiHOG000047313.
    KOiK00758.
    OMAiHYRITED.
    OrthoDBiEOG61ZTGG.

    Family and domain databases

    Gene3Di3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    HAMAPiMF_01628. Thymid_phosp.
    InterProiIPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR018090. Pyrmidine_PPas_bac/euk.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR013465. Thymidine_Pase.
    [Graphical view]
    PANTHERiPTHR10515. PTHR10515. 1 hit.
    PfamiPF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000478. TP_PyNP. 1 hit.
    SMARTiSM00941. PYNP_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsiTIGR02643. T_phosphoryl. 1 hit.
    TIGR02644. Y_phosphoryl. 1 hit.
    PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0KCQ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFLPQEFIRR KRDGQPLDRD DMAAFVRGVT DGSVTEGQVA AFAMAVYFND    50
    LSTDERVALT LAQRDSGDVL DWRALDLGGP VIDKHSTGGV GDVVSLMLGP 100
    MVAACGGYVP MISGRGLGHT GGTLDKLSAI PGYDVMPDTD AFRRTVREVG 150
    VAIIGQTARL APADKRIYAI RDVTATVESV AMITASILSK KLAAGLDGLV 200
    MDVKVGSGAF MPTAEKSAEL ARSIVDVGNG AGMKTTAILT DMNQSLAPCA 250
    GNALEVACAI DYLTGKSRPA RLHDVTMALS AELLVTGGLA RDAAHAREKL 300
    QQALDSGAAA ERFARMVAAL GGPADLLDAP ARHLARAAVI VPVPAPVSGV 350
    VQRVDCRALG LAVVALGGGR TRAEDAIDVS VGLSALAEIG QRIEAGEPLG 400
    FVHARDEAAA AHAVDAIRRG YVLGETGEAP PTLYQRVD 438
    Length:438
    Mass (Da):45,454
    Last modified:December 12, 2006 - v1
    Checksum:i1EEEEB4AC6F92063
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000460 Genomic DNA. Translation: ABK12972.1.
    RefSeqiWP_011545784.1. NC_008544.1.
    YP_839865.1. NC_008544.1.

    Genome annotation databases

    EnsemblBacteriaiABK12972; ABK12972; Bcen2424_6240.
    GeneIDi4454316.
    KEGGibch:Bcen2424_6240.
    PATRICi19070153. VBIBurCen15205_6387.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000460 Genomic DNA. Translation: ABK12972.1 .
    RefSeqi WP_011545784.1. NC_008544.1.
    YP_839865.1. NC_008544.1.

    3D structure databases

    ProteinModelPortali A0KCQ9.
    SMRi A0KCQ9. Positions 1-437.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 331272.Bcen2424_6240.

    Proteomic databases

    PRIDEi A0KCQ9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK12972 ; ABK12972 ; Bcen2424_6240 .
    GeneIDi 4454316.
    KEGGi bch:Bcen2424_6240.
    PATRICi 19070153. VBIBurCen15205_6387.

    Phylogenomic databases

    eggNOGi COG0213.
    HOGENOMi HOG000047313.
    KOi K00758.
    OMAi HYRITED.
    OrthoDBi EOG61ZTGG.

    Enzyme and pathway databases

    UniPathwayi UPA00578 ; UER00638 .
    BioCyci BCEN331272:GHR7-6325-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    HAMAPi MF_01628. Thymid_phosp.
    InterProi IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR018090. Pyrmidine_PPas_bac/euk.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR013465. Thymidine_Pase.
    [Graphical view ]
    PANTHERi PTHR10515. PTHR10515. 1 hit.
    Pfami PF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000478. TP_PyNP. 1 hit.
    SMARTi SM00941. PYNP_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsi TIGR02643. T_phosphoryl. 1 hit.
    TIGR02644. Y_phosphoryl. 1 hit.
    PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 3 of Burkholderia cenocepacia HI2424."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.
      , Kim E., LiPuma J.J., Gonzalez C.F., Konstantinidis K., Tiedje J.M., Richardson P.
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HI2424.

    Entry informationi

    Entry nameiTYPH_BURCH
    AccessioniPrimary (citable) accession number: A0KCQ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3