A0KA00 (KYNB_BURCH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kynurenine formamidase
Short name=KFA
EC=3.5.1.9

Alternative name(s):
N-formylkynurenine formamidase

Gene names

Name:	kynB
Ordered Locus Names:	Bcen2424_2577

Organism

Burkholderia cenocepacia (strain HI2424) [Complete proteome] [HAMAP]

Taxonomic identifier

331272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine By similarity.
Catalytic activity	N-formyl-L-kynurenine + H2O = formate + L-kynurenine.
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.
Sequence similarities	Belongs to the kynB family.

Ontologies

Keywords
Biological process	Tryptophan catabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	anthranilate metabolic process Inferred from sequence or structural similarity. Source: UniProtKB tryptophan catabolic process to kynurenine Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	arylformamidase activity Inferred from sequence or structural similarity. Source: UniProtKB formamidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 213	213	Kynurenine formamidase		PRO_0000362102

Sequences

	Sequence		Length	Mass (Da)
	A0KA00 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 14FC982FE7516C19	FASTA	213	22,677
	10 20 30 40 50 60 MDTLWDISPP VSPATPVWPG DTPVAVERVW RMEAGSPVNV ARLTLSPHTG AHCDAPLHYD 70 80 90 100 110 120 ADGAPIGAVP LDTYLGPCRV IHCIGASPVV RPADVEAALD GVPPRVLLRT YARAAVEQWD 130 140 150 160 170 180 SNFCAVAPDT VDLLAAHGVK LIGIDTPSLD PQESKTMDAH HRVRAHRMAI LEGIVLDDVP 190 200 210 PGDYELIALP LKFATLDASP VRAVLRALPA HAS

References

[1]

"Complete sequence of chromosome 1 of Burkholderia cenocepacia HI2424." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., LiPuma J.J., Gonzalez C.F., Konstantinidis K., Tiedje J.M., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HI2424.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000458 Genomic DNA. Translation: ABK09327.1.
RefSeq	YP_836220.1. NC_008542.1.
3D structure databases
ProteinModelPortal	A0KA00.
ModBase	Search...
Protein-protein interaction databases
STRING	A0KA00.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4449918.
GenomeReviews	Gene locus Bcen2424_2577 in contig CP000458_GR.
KEGG	bch:Bcen2424_2577.
PATRIC	19062584. VBIBurCen15205_2629.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1878.
HOGENOM	HBG686791.
OMA	HTSKWPL.
ProtClustDB	CLSK930430.
Enzyme and pathway databases
BioCyc	BCEN331272:BCEN2424_2577-MONOMER.
Family and domain databases
InterPro	IPR017484. Arylformamidase. IPR007325. Cyclase. [Graphical view]
KO	K07130.
Pfam	PF04199. Cyclase. 1 hit. [Graphical view]
TIGRFAMs	TIGR03035. Trp_arylform. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KYNB_BURCH

Accession

Primary (citable) accession number: A0KA00

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	December 12, 2006
Last modified:	December 14, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program