Reviewed, UniProtKB/Swiss-Prot A0K936 (PSD_BURCH)

Names and origin

Protein names

Recommended name:
    Phosphatidylserine decarboxylase proenzyme
    EC=4.1.1.65
Cleaved into the following 2 chains:
    1- Recommended name:
            Phosphatidylserine decarboxylase alpha chain
    2- Recommended name:
            Phosphatidylserine decarboxylase beta chain

Gene names

Name:	psd
Ordered Locus Names:	Bcen2424_2262

Organism

Burkholderia cenocepacia (strain HI2424) [Complete proteome] [HAMAP]

Taxonomic identifier

331272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	214 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. HAMAP MF_00664
Cofactor	Pyruvoyl group By similarity.
Pathway	Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. HAMAP MF_00664
Sequence similarities	Belongs to the phosphatidylserine decarboxylase family. Type 3 subfamily.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
PTM	Zymogen
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phosphatidylethanolamine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	cofactor binding Inferred from electronic annotation. Source: InterPro phosphatidylserine decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 181	181	Phosphatidylserine decarboxylase beta chain By similarity		PRO_1000026632
	Chain	182 – 214	33	Phosphatidylserine decarboxylase alpha chain By similarity		PRO_1000026633
Sites
	Site	181 – 182	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	182	1	Pyruvic acid (Ser) By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0K936-1 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 1800E0DBBF7F8A45	FASTA	214	23,446
	10 20 30 40 50 60 MNYPHPIIAR EGWPFIAIAA VVALLIHAVG GFGFAWPFWL LLVFVVQFFR DPQRPIPAQP 70 80 90 100 110 120 NAVLCPADGR IVAVETAQDP YANREALKIS VFMNVFNVHS QRSPVDGAIS KVEYFPGAFL 130 140 150 160 170 180 NAAIDKASTE NERNAVVIQT ASGKTVTSVQ IAGLIARRIL CYVRAGEPLS RGQRYGFIRF 190 200 210 GSRVDVYLPL GSRAKVSIGE KVYASSTILA ELEQ

References

[1]

"Complete sequence of chromosome 1 of Burkholderia cenocepacia HI2424." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., LiPuma J.J., Gonzalez C.F., Konstantinidis K., Tiedje J.M., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000458 Genomic DNA. Translation: ABK09013.1.
RefSeq	YP_835906.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A0K936.
Genome annotation databases
GeneID	4449308.
GenomeReviews	Gene locus Bcen2424_2262 in contig CP000458_GR.
KEGG	bch:Bcen2424_2262.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	A0K936.
OMA	DKASEDN.
Family and domain databases
HAMAP	MF_00664. [Tree]
InterPro	IPR003817. PS_Dcarbxylase. IPR004428. PtdSer_deCO2ase_related. [Graphical view]
Pfam	PF02666. PS_Dcarbxylase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00164. PS_decarb_rel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PSD_BURCH

Accession

Primary (citable) accession number: A0K936

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	December 12, 2006
Last modified:	November 3, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)