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A0K8D0

- LPXB_BURCH

UniProt

A0K8D0 - LPXB_BURCH

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Burkholderia cenocepacia (strain HI2424)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciBCEN331272:GHR7-2056-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:Bcen2424_2006
    OrganismiBurkholderia cenocepacia (strain HI2424)
    Taxonomic identifieri331272 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
    ProteomesiUP000000776: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 389389Lipid-A-disaccharide synthasePRO_1000049385Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi331272.Bcen2424_2006.

    Structurei

    3D structure databases

    ProteinModelPortaliA0K8D0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OMAiIARMLVN.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A0K8D0-1 [UniParc]FASTAAdd to Basket

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    MPLPTNQLRL AMVAGEPSGD LLAASLLGGL RERLPESAQY YGIGGQRMIA    50
    QGFDSHWQMD KLTVRGYVEA LGQIPEILRI RGELKRQLLA ERPAAFIGVD 100
    APDFNFNVEQ AARDAGIPSI HFVCPSIWAW RGGRIKKIAK SVDHMLCLFP 150
    FEPAILDKAG VASTYVGHPL ADDIPLEPDT HGARIALGLP ADGPVIAVLP 200
    GSRRSEIALI GPTFFAAMAL MQQREPGVRF VMPAATPALR ELLQPLVDAH 250
    PQLALTITDG RSQVAMTAAD AILVKSGTVT LEAALLKKPM VISYKVPWLT 300
    GQIMRRQGYL PYVGLPNILA GRFVVPELLQ HFATPEALAD ATLTQLSDDA 350
    NRRTLTEVFT EMHLSLRQNT AAKAAEAVVR VLEQRKGRA 389
    Length:389
    Mass (Da):42,259
    Last modified:December 12, 2006 - v1
    Checksum:i380F666EDD039534
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000458 Genomic DNA. Translation: ABK08757.1.
    RefSeqiWP_011549546.1. NC_008542.1.
    YP_835650.1. NC_008542.1.

    Genome annotation databases

    EnsemblBacteriaiABK08757; ABK08757; Bcen2424_2006.
    GeneIDi4448460.
    KEGGibch:Bcen2424_2006.
    PATRICi19061359. VBIBurCen15205_2039.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000458 Genomic DNA. Translation: ABK08757.1 .
    RefSeqi WP_011549546.1. NC_008542.1.
    YP_835650.1. NC_008542.1.

    3D structure databases

    ProteinModelPortali A0K8D0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 331272.Bcen2424_2006.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK08757 ; ABK08757 ; Bcen2424_2006 .
    GeneIDi 4448460.
    KEGGi bch:Bcen2424_2006.
    PATRICi 19061359. VBIBurCen15205_2039.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OMAi IARMLVN.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci BCEN331272:GHR7-2056-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Burkholderia cenocepacia HI2424."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.
      , Kim E., LiPuma J.J., Gonzalez C.F., Konstantinidis K., Tiedje J.M., Richardson P.
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HI2424.

    Entry informationi

    Entry nameiLPXB_BURCH
    AccessioniPrimary (citable) accession number: A0K8D0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3