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A0K6X5

- IF2_BURCH

UniProt

A0K6X5 - IF2_BURCH

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Protein
Translation initiation factor IF-2
Gene
infB, Bcen2424_1500
Organism
Burkholderia cenocepacia (strain HI2424)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi480 – 4878GTP By similarity
Nucleotide bindingi526 – 5305GTP By similarity
Nucleotide bindingi580 – 5834GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTPase activity Source: UniProtKB-HAMAP
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBCEN331272:GHR7-1541-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor IF-2
    Gene namesi
    Name:infB
    Ordered Locus Names:Bcen2424_1500
    OrganismiBurkholderia cenocepacia (strain HI2424)
    Taxonomic identifieri331272 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
    ProteomesiUP000000776: Chromosome 1

    Subcellular locationi

    Cytoplasm By similarity UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 971971Translation initiation factor IF-2UniRule annotation
    PRO_1000008209Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi331272.Bcen2424_1500.

    Structurei

    3D structure databases

    ProteinModelPortaliA0K6X5.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini471 – 640170tr-type G
    Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni480 – 4878G1 By similarity
    Regioni505 – 5095G2 By similarity
    Regioni526 – 5294G3 By similarity
    Regioni580 – 5834G4 By similarity
    Regioni616 – 6183G5 By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0532.
    HOGENOMiHOG000076907.
    KOiK02519.
    OMAiDATGKTR.
    OrthoDBiEOG67HJSV.

    Family and domain databases

    Gene3Di3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00100_B. IF_2_B.
    InterProiIPR009061. DNA-bd_dom_put.
    IPR000795. EF_GTP-bd_dom.
    IPR013575. IF2_assoc_dom_bac.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view]
    PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 2 hits.
    PF11987. IF-2. 1 hit.
    PF08364. IF2_assoc. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view]
    SUPFAMiSSF46955. SSF46955. 1 hit.
    SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0K6X5-1 [UniParc]FASTAAdd to Basket

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    MASNNVAQFA AELKMPAGVL LEQLQAAGVQ KASEDDALSE TDKARLLDHL    50
    RKSHGATDGD KRKITLTRKH TSEIKQSDAT GKARTIQVEV RKKRTFVKRD 100
    DVAEGADQGQ AQVAEADDDA ELKRREEEAR REAELLEKQA QELRERQERL 150
    EREEAERRAR EEAAEAERRR AEEEAATKRA AAEVAAAQQQ AAAQQAAAEQ 200
    EATPTQSAQD EARAAAERAA QREAAKKAED AAREAADKAR AEQEEISKRR 250
    AAAEAEARAI REMMNTPRKA VVKAVEPPKP VEPPKPAEAK GTLHKPAKPE 300
    GAQARPAVKK PAGAAAPATT QAPAGAGDRN KKPGAGKGGW QDDAAKRRGI 350
    KTRGDSSGGV DRGWRGGPKG RGRHQDSSTF QAPTEPIVRE VHVPETVSVA 400
    DLAHKMSIKA SEVIKVMMKM GQMVTINQVL DQETAMIIVE ELGHRAVAAK 450
    LDDPEALLVE GESGTDAEQL PRPPVVTVMG HVDHGKTSLL DHIRRAKVAA 500
    GEAGGITQHI GAYHVDTPRG VITFLDTPGH EAFTAMRARG AKATDIVVLV 550
    VAADDGVMPQ TKEAIAHAKA GGVPIVVAIN KIDKPEANPD RVKQELVAEG 600
    VVPEEYGGDS PFVPVSAKTG AGIDDLLENV LLQAEVLELK APVEAPAKGI 650
    VIEAKLDKGK GPVATILVQS GTLNRGDIVL AGTAYGRVRA MLDENGKPTK 700
    EAGPSIPVEI QGLSEVPGAG EEVIVLPDER KAREIALFRQ GKFRDVKLAK 750
    QQAAKLESML EQMGEGEVQN LPLIIKADVQ GSQEALVQSL LKLSTDEVRV 800
    QIVHSAVGGI SENDVNLATA SKAVIIGFNT RADAQARKLA EANGIDIRYY 850
    NIIYDAVDEV KAAMSGMLAP EKREVITGMV EVRQVFKVPK IGTVAGCMVT 900
    DGIVKRSSSV RVLRNNVVIF TGELESLKRF KDDVKEVKQG FECGMSVKNF 950
    NDVTEGDQFE VFEVTEVART L 971
    Length:971
    Mass (Da):104,278
    Last modified:December 12, 2006 - v1
    Checksum:i90A5E7DB5D59FA23
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000458 Genomic DNA. Translation: ABK08252.1.
    RefSeqiWP_011545261.1. NC_008542.1.
    YP_835145.1. NC_008542.1.

    Genome annotation databases

    EnsemblBacteriaiABK08252; ABK08252; Bcen2424_1500.
    GeneIDi4448619.
    KEGGibch:Bcen2424_1500.
    PATRICi19060271. VBIBurCen15205_1507.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000458 Genomic DNA. Translation: ABK08252.1 .
    RefSeqi WP_011545261.1. NC_008542.1.
    YP_835145.1. NC_008542.1.

    3D structure databases

    ProteinModelPortali A0K6X5.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 331272.Bcen2424_1500.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK08252 ; ABK08252 ; Bcen2424_1500 .
    GeneIDi 4448619.
    KEGGi bch:Bcen2424_1500.
    PATRICi 19060271. VBIBurCen15205_1507.

    Phylogenomic databases

    eggNOGi COG0532.
    HOGENOMi HOG000076907.
    KOi K02519.
    OMAi DATGKTR.
    OrthoDBi EOG67HJSV.

    Enzyme and pathway databases

    BioCyci BCEN331272:GHR7-1541-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00100_B. IF_2_B.
    InterProi IPR009061. DNA-bd_dom_put.
    IPR000795. EF_GTP-bd_dom.
    IPR013575. IF2_assoc_dom_bac.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view ]
    PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 2 hits.
    PF11987. IF-2. 1 hit.
    PF08364. IF2_assoc. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view ]
    SUPFAMi SSF46955. SSF46955. 1 hit.
    SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Burkholderia cenocepacia HI2424."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.
      , Kim E., LiPuma J.J., Gonzalez C.F., Konstantinidis K., Tiedje J.M., Richardson P.
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HI2424.

    Entry informationi

    Entry nameiIF2_BURCH
    AccessioniPrimary (citable) accession number: A0K6X5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: December 12, 2006
    Last modified: September 3, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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