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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Burkholderia cenocepacia (strain HI2424)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi480 – 487GTPUniRule annotation8
Nucleotide bindingi526 – 530GTPUniRule annotation5
Nucleotide bindingi580 – 583GTPUniRule annotation4

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:Bcen2424_1500
OrganismiBurkholderia cenocepacia (strain HI2424)
Taxonomic identifieri331272 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000082091 – 971Translation initiation factor IF-2Add BLAST971

Structurei

3D structure databases

ProteinModelPortaliA0K6X5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini471 – 640tr-type GAdd BLAST170

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni480 – 487G1By similarity8
Regioni505 – 509G2By similarity5
Regioni526 – 529G3By similarity4
Regioni580 – 583G4By similarity4
Regioni616 – 618G5By similarity3

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076907.
KOiK02519.
OMAiEVIKQMM.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B. 1 hit.
InterProiIPR009061. DNA-bd_dom_put.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0K6X5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNNVAQFA AELKMPAGVL LEQLQAAGVQ KASEDDALSE TDKARLLDHL
60 70 80 90 100
RKSHGATDGD KRKITLTRKH TSEIKQSDAT GKARTIQVEV RKKRTFVKRD
110 120 130 140 150
DVAEGADQGQ AQVAEADDDA ELKRREEEAR REAELLEKQA QELRERQERL
160 170 180 190 200
EREEAERRAR EEAAEAERRR AEEEAATKRA AAEVAAAQQQ AAAQQAAAEQ
210 220 230 240 250
EATPTQSAQD EARAAAERAA QREAAKKAED AAREAADKAR AEQEEISKRR
260 270 280 290 300
AAAEAEARAI REMMNTPRKA VVKAVEPPKP VEPPKPAEAK GTLHKPAKPE
310 320 330 340 350
GAQARPAVKK PAGAAAPATT QAPAGAGDRN KKPGAGKGGW QDDAAKRRGI
360 370 380 390 400
KTRGDSSGGV DRGWRGGPKG RGRHQDSSTF QAPTEPIVRE VHVPETVSVA
410 420 430 440 450
DLAHKMSIKA SEVIKVMMKM GQMVTINQVL DQETAMIIVE ELGHRAVAAK
460 470 480 490 500
LDDPEALLVE GESGTDAEQL PRPPVVTVMG HVDHGKTSLL DHIRRAKVAA
510 520 530 540 550
GEAGGITQHI GAYHVDTPRG VITFLDTPGH EAFTAMRARG AKATDIVVLV
560 570 580 590 600
VAADDGVMPQ TKEAIAHAKA GGVPIVVAIN KIDKPEANPD RVKQELVAEG
610 620 630 640 650
VVPEEYGGDS PFVPVSAKTG AGIDDLLENV LLQAEVLELK APVEAPAKGI
660 670 680 690 700
VIEAKLDKGK GPVATILVQS GTLNRGDIVL AGTAYGRVRA MLDENGKPTK
710 720 730 740 750
EAGPSIPVEI QGLSEVPGAG EEVIVLPDER KAREIALFRQ GKFRDVKLAK
760 770 780 790 800
QQAAKLESML EQMGEGEVQN LPLIIKADVQ GSQEALVQSL LKLSTDEVRV
810 820 830 840 850
QIVHSAVGGI SENDVNLATA SKAVIIGFNT RADAQARKLA EANGIDIRYY
860 870 880 890 900
NIIYDAVDEV KAAMSGMLAP EKREVITGMV EVRQVFKVPK IGTVAGCMVT
910 920 930 940 950
DGIVKRSSSV RVLRNNVVIF TGELESLKRF KDDVKEVKQG FECGMSVKNF
960 970
NDVTEGDQFE VFEVTEVART L
Length:971
Mass (Da):104,278
Last modified:December 12, 2006 - v1
Checksum:i90A5E7DB5D59FA23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000458 Genomic DNA. Translation: ABK08252.1.
RefSeqiWP_011545261.1. NC_008542.1.

Genome annotation databases

EnsemblBacteriaiABK08252; ABK08252; Bcen2424_1500.
KEGGibch:Bcen2424_1500.
PATRICi19060271. VBIBurCen15205_1507.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000458 Genomic DNA. Translation: ABK08252.1.
RefSeqiWP_011545261.1. NC_008542.1.

3D structure databases

ProteinModelPortaliA0K6X5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK08252; ABK08252; Bcen2424_1500.
KEGGibch:Bcen2424_1500.
PATRICi19060271. VBIBurCen15205_1507.

Phylogenomic databases

HOGENOMiHOG000076907.
KOiK02519.
OMAiEVIKQMM.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B. 1 hit.
InterProiIPR009061. DNA-bd_dom_put.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIF2_BURCH
AccessioniPrimary (citable) accession number: A0K6X5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: November 2, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.