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Protein

Inositol 2-dehydrogenase

Gene

iolG

Organism
Burkholderia cenocepacia (strain HI2424)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose).UniRule annotation

Catalytic activityi

Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol 2-dehydrogenaseUniRule annotation (EC:1.1.1.18UniRule annotation)
Alternative name(s):
Myo-inositol 2-dehydrogenaseUniRule annotation
Short name:
MI 2-dehydrogenaseUniRule annotation
Gene namesi
Name:iolGUniRule annotation
Ordered Locus Names:Bcen2424_1428
OrganismiBurkholderia cenocepacia (strain HI2424)
Taxonomic identifieri331272 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003525611 – 337Inositol 2-dehydrogenaseAdd BLAST337

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA0K6Q3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Gfo/Idh/MocA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000227439.
KOiK00010.
OMAiACCEAGV.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01671. IolG. 1 hit.
InterProiIPR023794. MI/DCI_dehydrogenase.
IPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
IPR004104. OxRdtase_C.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
PF02894. GFO_IDH_MocA_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

A0K6Q3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLQIGVIGC GAIGQDHIRR LTRTLSGARV VAVNDIDPQQ ARDAVTKYGL
60 70 80 90 100
DAEIYGDGHE VVAAADVQAV LVTSWGPTHE AFVLDAIAHG KPVFCEKPLA
110 120 130 140 150
VTAEGCMRIV EAEVAHGKRL VQVGFMRPYD EGYRALKRVI DSGQIGAPLM
160 170 180 190 200
LHCAHRNQSV GERYTTDMAI TDTLIHELDV LRWLLGEDYA SAQVVYPKKT
210 220 230 240 250
RHASAHLADP QIVLLETASG VRIDVEIFVN CQYGYDIQCE VVGEQGIAKL
260 270 280 290 300
PDPPAVGLKH AARQSVEIMT DWKERFIASY DVELQAFIDG VRQGALTGPS
310 320 330
AWDGYAAAVA ADACVRAQQS GAVEPIAMAE RPAFYRG
Length:337
Mass (Da):36,547
Last modified:December 12, 2006 - v1
Checksum:i915E9D19105493AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000458 Genomic DNA. Translation: ABK08180.1.
RefSeqiWP_011545209.1. NC_008542.1.

Genome annotation databases

EnsemblBacteriaiABK08180; ABK08180; Bcen2424_1428.
KEGGibch:Bcen2424_1428.
PATRICi19060123. VBIBurCen15205_1435.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000458 Genomic DNA. Translation: ABK08180.1.
RefSeqiWP_011545209.1. NC_008542.1.

3D structure databases

ProteinModelPortaliA0K6Q3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK08180; ABK08180; Bcen2424_1428.
KEGGibch:Bcen2424_1428.
PATRICi19060123. VBIBurCen15205_1435.

Phylogenomic databases

HOGENOMiHOG000227439.
KOiK00010.
OMAiACCEAGV.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01671. IolG. 1 hit.
InterProiIPR023794. MI/DCI_dehydrogenase.
IPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
IPR004104. OxRdtase_C.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
PF02894. GFO_IDH_MocA_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIOLG_BURCH
AccessioniPrimary (citable) accession number: A0K6Q3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: December 12, 2006
Last modified: November 2, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.