Reviewed, UniProtKB/Swiss-Prot A0K6E4 (UPPP2_BURCH)

Names and origin

Protein names

Recommended name:
    Undecaprenyl-diphosphatase 2
    EC=3.6.1.27
Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase 2
    Bacitracin resistance protein 2

Gene names

Name:	uppP2
Ordered Locus Names:	Bcen2424_1319

Organism

Burkholderia cenocepacia (strain HI2424) [Complete proteome] [HAMAP]

Taxonomic identifier

331272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the uppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 276	276	Undecaprenyl-diphosphatase 2 HAMAP MF_01006		PRO_0000290692
Regions
	Transmembrane	1 – 21	21	Potential
	Transmembrane	44 – 64	21	Potential
	Transmembrane	87 – 107	21	Potential
	Transmembrane	114 – 134	21	Potential
	Transmembrane	150 – 170	21	Potential
	Transmembrane	190 – 210	21	Potential
	Transmembrane	222 – 242	21	Potential
	Transmembrane	251 – 271	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	A0K6E4-1 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: A949403217C71907	FASTA	276	30,218
	10 20 30 40 50 60 MSLWFLVFLS VLQGVTELFP VSSLGHTLLV PALFGMHIDK HAPQLLPFLV ALHLGTALAL 70 80 90 100 110 120 LWYFRARWIA LIGGFFAQLG GRKNDDGHLM WALIIGTIPT GIVGLLLEKR IERVFHDLRI 130 140 150 160 170 180 VAIALIVNGV LLWLGDRIQR SRAHQAPEKM TFKQAFFVGL AQIGALIPGF SRSGLTMIAG 190 200 210 220 230 240 NVAGLTAEKA AEFSFLLGTP IIFAAGVLEL PKLFHARDQL ADALLGGVLT AIAAYLSVRF 250 260 270 LMRYFEGRGR LASFGVYCVI AGVFCLGWFM LHPQPV

References

[1]

"Complete sequence of chromosome 1 of Burkholderia cenocepacia HI2424." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., LiPuma J.J., Gonzalez C.F., Konstantinidis K., Tiedje J.M., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000458 Genomic DNA. Translation: ABK08071.1.
RefSeq	YP_834964.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A0K6E4.
Genome annotation databases
GeneID	4450741.
GenomeReviews	Gene locus Bcen2424_1319 in contig CP000458_GR.
KEGG	bch:Bcen2424_1319.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	A0K6E4.
OMA	FALLWYF.
Family and domain databases
HAMAP	MF_01006. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UPPP2_BURCH

Accession

Primary (citable) accession number: A0K6E4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	December 12, 2006
Last modified:	November 3, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)