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A0K6E4 (UPPP2_BURCH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase 2

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein 2
Undecaprenyl pyrophosphate phosphatase 2
Gene names
Name:uppP2
Ordered Locus Names:Bcen2424_1319
OrganismBurkholderia cenocepacia (strain HI2424) [Complete proteome] [HAMAP]
Taxonomic identifier331272 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex

Protein attributes

Sequence length276 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 276276Undecaprenyl-diphosphatase 2 HAMAP-Rule MF_01006
PRO_0000290692

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane44 – 6421Helical; Potential
Transmembrane87 – 10721Helical; Potential
Transmembrane114 – 13421Helical; Potential
Transmembrane150 – 17021Helical; Potential
Transmembrane190 – 21021Helical; Potential
Transmembrane222 – 24221Helical; Potential
Transmembrane251 – 27121Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A0K6E4 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: A949403217C71907

FASTA27630,218
        10         20         30         40         50         60 
MSLWFLVFLS VLQGVTELFP VSSLGHTLLV PALFGMHIDK HAPQLLPFLV ALHLGTALAL 

        70         80         90        100        110        120 
LWYFRARWIA LIGGFFAQLG GRKNDDGHLM WALIIGTIPT GIVGLLLEKR IERVFHDLRI 

       130        140        150        160        170        180 
VAIALIVNGV LLWLGDRIQR SRAHQAPEKM TFKQAFFVGL AQIGALIPGF SRSGLTMIAG 

       190        200        210        220        230        240 
NVAGLTAEKA AEFSFLLGTP IIFAAGVLEL PKLFHARDQL ADALLGGVLT AIAAYLSVRF 

       250        260        270 
LMRYFEGRGR LASFGVYCVI AGVFCLGWFM LHPQPV 

« Hide

References

[1]"Complete sequence of chromosome 1 of Burkholderia cenocepacia HI2424."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., LiPuma J.J., Gonzalez C.F., Konstantinidis K., Tiedje J.M., Richardson P.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HI2424.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000458 Genomic DNA. Translation: ABK08071.1.
RefSeqYP_834964.1. NC_008542.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING331272.Bcen2424_1319.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK08071; ABK08071; Bcen2424_1319.
GeneID4450741.
KEGGbch:Bcen2424_1319.
PATRIC19059905. VBIBurCen15205_1329.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAWEFLATG.
OrthoDBEOG6QP13M.
ProtClustDBPRK12554.

Enzyme and pathway databases

BioCycBCEN331272:GHR7-1357-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP2_BURCH
AccessionPrimary (citable) accession number: A0K6E4
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: December 12, 2006
Last modified: February 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families