A0K5L4 (UBIG_BURCH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-demethylubiquinone-9 3-methyltransferase
EC=2.1.1.64

Alternative name(s):
2-polyprenyl-6-hydroxyphenyl methylase
EC=2.1.1.222
3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase
Short name=DHHB methyltransferase

Gene names

Name:	ubiG
Ordered Locus Names:	Bcen2424_1038

Organism

Burkholderia cenocepacia (strain HI2424) [Complete proteome] [HAMAP]

Taxonomic identifier

331272 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex › Burkholderia cenocepacia

Protein attributes

Sequence length	232 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Non-specific O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway By similarity. HAMAP-Rule MF_00472
Catalytic activity	S-adenosyl-L-methionine + 3-demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n. HAMAP-Rule MF_00472 S-adenosyl-L-methionine + 3-(all-trans-polyprenyl)benzene-1,2-diol = S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-polyprenyl)phenol. HAMAP-Rule MF_00472
Pathway	Cofactor biosynthesis; ubiquinone biosynthesis. HAMAP-Rule MF_00472
Sequence similarities	Belongs to the methyltransferase superfamily. UbiG/COQ3 family.

Ontologies

Keywords
Biological process	Ubiquinone biosynthesis
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	ubiquinone biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity Inferred from electronic annotation. Source: InterPro 3-demethylubiquinone-9 3-O-methyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 232	232	3-demethylubiquinone-9 3-methyltransferase HAMAP-Rule MF_00472		PRO_1000013894

Sequences

	Sequence		Length	Mass (Da)
	A0K5L4 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: DA08760A324CDC27	FASTA	232	25,211
	10 20 30 40 50 60 MTNADPHELQ KFSDLAHRWW DPNAEFKPLH DLNPVRLGWI DAHAHLAGKR ALDIGCGGGI 70 80 90 100 110 120 LSESMAGLGA QVKGIDLSTE ALGVADLHSL ESGISVEYEA IAAEAIAARE PGTYDVVTCM 130 140 150 160 170 180 EMLEHVPSPG DIVAACATLV KPGGWVFFST LNRNLKSYLF AVIGAEYIAQ MLPKGTHDYA 190 200 210 220 230 RFIRPSELAS FVRATDLHIV EIKGITYHPI GKRFALSNDT DINYLVACRR GA

References

[1]

"Complete sequence of chromosome 1 of Burkholderia cenocepacia HI2424." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., LiPuma J.J., Gonzalez C.F., Konstantinidis K., Tiedje J.M., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HI2424.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000458 Genomic DNA. Translation: ABK07791.1.
RefSeq	YP_834684.1. NC_008542.1.
3D structure databases
ProteinModelPortal	A0K5L4.
ModBase	Search...
Protein-protein interaction databases
STRING	331272.Bcen2424_1038.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABK07791; ABK07791; Bcen2424_1038.
GeneID	4451083.
KEGG	bch:Bcen2424_1038.
PATRIC	19059310. VBIBurCen15205_1038.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2227.
HOGENOM	HOG000278065.
KO	K00568.
OMA	VIRACHR.
ProtClustDB	PRK05134.
Enzyme and pathway databases
BioCyc	BCEN331272:GHR7-4904-MONOMER.
UniPathway	UPA00232.
Family and domain databases
HAMAP	MF_00472. UbiG.
InterPro	IPR010233. UbiG_MeTrfase. [Graphical view]
PANTHER	PTHR23134. PTHR23134. 1 hit.
TIGRFAMs	TIGR01983. UbiG. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UBIG_BURCH

Accession

Primary (citable) accession number: A0K5L4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	December 12, 2006
Last modified:	May 1, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program