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A0K593

- UPPP1_BURCH

UniProt

A0K593 - UPPP1_BURCH

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Protein
Undecaprenyl-diphosphatase 1
Gene
uppP1, Bcen2424_0917
Organism
Burkholderia cenocepacia (strain HI2424)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciBCEN331272:GHR7-941-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase 1 (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein 1
Undecaprenyl pyrophosphate phosphatase 1
Gene namesi
Name:uppP1
Ordered Locus Names:Bcen2424_0917
OrganismiBurkholderia cenocepacia (strain HI2424)
Taxonomic identifieri331272 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
ProteomesiUP000000776: Chromosome 1

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei83 – 10321Helical; Reviewed prediction
Add
BLAST
Transmembranei108 – 12821Helical; Reviewed prediction
Add
BLAST
Transmembranei187 – 20721Helical; Reviewed prediction
Add
BLAST
Transmembranei217 – 23721Helical; Reviewed prediction
Add
BLAST
Transmembranei252 – 27221Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 276276Undecaprenyl-diphosphatase 1UniRule annotation
PRO_0000290691Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi331272.Bcen2424_0917.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiWFIIVAT.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

A0K593-1 [UniParc]FASTAAdd to Basket

« Hide

MDWILICKAL ILGVVEGLTE FLPVSSTGHL IVAGSFLNFN DSHAKTFDVV    50
IQFGAILAVC WEYRQRIVSV VSGLPSRPDA QRFTLNVVIA TIPAIALGLL 100
FEKKIKAVLF SPVPVAFALV VGGAIILWAE ARQRERSEPP RVMSVDALTP 150
LDALKVGIAQ CFALVPGMSR SGSTIIGGML FGLDRRVATE FSFFLAIPII 200
FGATLYETVK DWQAFTVDSL GLFALGLVAA FVSAFVCVRW LLRYVATHDF 250
TVFAWYRIAF GLFVLLVGYS GWLNWA 276
Length:276
Mass (Da):30,227
Last modified:December 12, 2006 - v1
Checksum:i2E18CE6F2C99B5EF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000458 Genomic DNA. Translation: ABK07670.1.
RefSeqiYP_834563.1. NC_008542.1.

Genome annotation databases

EnsemblBacteriaiABK07670; ABK07670; Bcen2424_0917.
GeneIDi4450864.
KEGGibch:Bcen2424_0917.
PATRICi19059058. VBIBurCen15205_0920.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000458 Genomic DNA. Translation: ABK07670.1 .
RefSeqi YP_834563.1. NC_008542.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 331272.Bcen2424_0917.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK07670 ; ABK07670 ; Bcen2424_0917 .
GeneIDi 4450864.
KEGGi bch:Bcen2424_0917.
PATRICi 19059058. VBIBurCen15205_0920.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218356.
KOi K06153.
OMAi WFIIVAT.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci BCEN331272:GHR7-941-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Burkholderia cenocepacia HI2424."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.
    , Kim E., LiPuma J.J., Gonzalez C.F., Konstantinidis K., Tiedje J.M., Richardson P.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HI2424.

Entry informationi

Entry nameiUPPP1_BURCH
AccessioniPrimary (citable) accession number: A0K593
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: December 12, 2006
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi