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A0K4Y2 (A0K4Y2_BURCH) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Serine hydroxymethyltransferase 1 HAMAP MF_00051
Short name=SHMT 1 HAMAP MF_00051
Short name=Serine methylase 1 HAMAP MF_00051
EC=2.1.2.1 HAMAP MF_00051
Gene names
Name:glyA1 HAMAP MF_00051
Ordered Locus Names:Bcen2424_0806
OrganismBurkholderia cenocepacia (strain HI2424) [Complete proteome] [HAMAP]
Taxonomic identifier331272 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length415 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Interconversion of serine and glycine By similarity. RuleBase RU000585 HAMAP MF_00051

Catalytic activity

5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. RuleBase RU000585 HAMAP MF_00051

Cofactor

Pyridoxal phosphate By similarity. RuleBase RU000585 HAMAP MF_00051

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_00051

One-carbon metabolism; tetrahydrofolate pathway. RuleBase RU000585

Subunit structure

Homotetramer By similarity. HAMAP MF_00051

Subcellular location

Cytoplasm By similarity HAMAP MF_00051.

Sequence similarities

Belongs to the SHMT family. RuleBase RU004104 HAMAP MF_00051

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Amino acid modifications

Modified residue2301N6-(pyridoxal phosphate)lysine By similarity HAMAP MF_00051

Sequences

Sequence LengthMass (Da)Tools
A0K4Y2 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 23DA2F79B0DC429A

FASTA41544,888
        10         20         30         40         50         60 
MFDRAQSTIA NVDPEIFAAI EQENRRQEDH IELIASENYT SPAVMAAQGS QLTNKYAEGY 

        70         80         90        100        110        120 
PGKRYYGGCE YVDVVEQLAI DRVKQLFGAE AANVQPNSGS QANQGVFFAM LKPGDTIMGM 

       130        140        150        160        170        180 
SLAHGGHLTH GSPVNMSGKW FNVVSYGLNE NEDIDYEAAE KLAQEHKPKL IVAGASAFAL 

       190        200        210        220        230        240 
KIDFERLAKI AKSVGAYLMV DMAHYAGLIA AGVYPNPVPH ADFVTTTTHK SLRGPRGGVI 

       250        260        270        280        290        300 
LMKAEYEKPI NSAIFPGIQG GPLMHVIAAK AVAFKEALSP EFKEYQQKVV ENARVLAETL 

       310        320        330        340        350        360 
VKRGLRIVSG RTESHVMLVD LRAKNITGKA AEAALGAAHI TVNKNAIPND PEKPFVTSGV 

       370        380        390        400        410 
RLGSPAMTTR GFGPAEAEQV GNLIADVLEN PEDAATIERV RAQVAELTKR FPVYR

« Hide

References

[1]"Complete sequence of chromosome 1 of Burkholderia cenocepacia HI2424."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., LiPuma J.J., Gonzalez C.F., Konstantinidis K., Tiedje J.M., Richardson P.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000458 Genomic DNA. Translation: ABK07559.1.
RefSeqYP_834452.1. NC_008542.1.

3D structure databases

ProteinModelPortalA0K4Y2.
SMRA0K4Y2. Positions 4-414.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0K4Y2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4450280.
GenomeReviewsGene locus Bcen2424_0806 in contig CP000458_GR.
KEGGbch:Bcen2424_0806.
PATRIC19058829. VBIBurCen15205_0806.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0112.
HOGENOMHBG301263.
OMAAHMTINK.
ProtClustDBPRK00011.

Family and domain databases

HAMAPMF_00051. SHMT.
[Tree]
InterProIPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR001085. Ser_HO-MeTrfase.
IPR019798. Ser_HO-MeTrfase_PLP_BS.
[Graphical view]
Gene3DG3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KOK00600.
PANTHERPTHR11680. Gly_HO-Metrfase. 1 hit.
PfamPF00464. SHMT. 1 hit.
[Graphical view]
PIRSFPIRSF000412. SHMT. 1 hit.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITEPS00096. SHMT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA0K4Y2_BURCH
AccessionPrimary (citable) accession number: A0K4Y2
Entry history
Integrated into UniProtKB/TrEMBL: December 12, 2006
Last sequence update: December 12, 2006
Last modified: December 14, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info