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Protein

Biosynthetic peptidoglycan transglycosylase

Gene

mtgA

Organism
Burkholderia cenocepacia (strain HI2424)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.UniRule annotation

Catalytic activityi

(GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n)-diphosphoundecaprenol + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = (GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n+1)-diphosphoundecaprenol + undecaprenyl diphosphate.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Protein family/group databases

CAZyiGT51. Glycosyltransferase Family 51.

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic peptidoglycan transglycosylaseUniRule annotation (EC:2.4.1.129UniRule annotation)
Alternative name(s):
Glycan polymeraseUniRule annotation
Peptidoglycan glycosyltransferase MtgAUniRule annotation
Short name:
PGTUniRule annotation
Gene namesi
Name:mtgAUniRule annotation
Ordered Locus Names:Bcen2424_0614
OrganismiBurkholderia cenocepacia (strain HI2424)
Taxonomic identifieri331272 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex

Subcellular locationi

  • Cell inner membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 42HelicalUniRule annotationAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000173001 – 245Biosynthetic peptidoglycan transglycosylaseAdd BLAST245

Structurei

3D structure databases

ProteinModelPortaliA0K4E0.
SMRiA0K4E0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 51 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000288116.
KOiK03814.
OMAiPAPKCFD.

Family and domain databases

Gene3Di1.10.3810.10. 1 hit.
HAMAPiMF_00766. PGT_MtgA. 1 hit.
InterProiView protein in InterPro
IPR001264. Glyco_trans_51.
IPR023346. Lysozyme-like_dom.
IPR011812. Pep_trsgly.
PfamiView protein in Pfam
PF00912. Transgly. 1 hit.
SUPFAMiSSF53955. SSF53955. 1 hit.
TIGRFAMsiTIGR02070. mono_pep_trsgly. 1 hit.

Sequencei

Sequence statusi: Complete.

A0K4E0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAVSGTQRT RTVSLARWAV YAGSVFAGAW LATQLFYLAQ IALWLFVNPG
60 70 80 90 100
STAFMRTDAW WLSRDTPPAQ IRHQWVPYDQ ISRNLKRALI ASEDSTFATN
110 120 130 140 150
NGYDVDAILQ AWEKNKARGR IVAGGSTITQ QLARNLFLSR EKSYIRKGQE
160 170 180 190 200
LIITWMLETV LDKERIFEIY LNSVEWGRGV YGAEAAARYY YKIPASRLGA
210 220 230 240
WQSARLAVML PKPRWFDAHR GSAYQAQRAA VIARRMGAAE LPQSE
Length:245
Mass (Da):27,768
Last modified:December 12, 2006 - v1
Checksum:iF1CD0362627E0F2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000458 Genomic DNA. Translation: ABK07367.1.
RefSeqiWP_011544539.1. NC_008542.1.

Genome annotation databases

EnsemblBacteriaiABK07367; ABK07367; Bcen2424_0614.
KEGGibch:Bcen2424_0614.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000458 Genomic DNA. Translation: ABK07367.1.
RefSeqiWP_011544539.1. NC_008542.1.

3D structure databases

ProteinModelPortaliA0K4E0.
SMRiA0K4E0.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGT51. Glycosyltransferase Family 51.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK07367; ABK07367; Bcen2424_0614.
KEGGibch:Bcen2424_0614.

Phylogenomic databases

HOGENOMiHOG000288116.
KOiK03814.
OMAiPAPKCFD.

Enzyme and pathway databases

UniPathwayiUPA00219.

Family and domain databases

Gene3Di1.10.3810.10. 1 hit.
HAMAPiMF_00766. PGT_MtgA. 1 hit.
InterProiView protein in InterPro
IPR001264. Glyco_trans_51.
IPR023346. Lysozyme-like_dom.
IPR011812. Pep_trsgly.
PfamiView protein in Pfam
PF00912. Transgly. 1 hit.
SUPFAMiSSF53955. SSF53955. 1 hit.
TIGRFAMsiTIGR02070. mono_pep_trsgly. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMTGA_BURCH
AccessioniPrimary (citable) accession number: A0K4E0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: June 7, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.