Reviewed, UniProtKB/Swiss-Prot A0K3W0 (HIS2_BURCH)

Names and origin

Protein names

Recommended name:
    Phosphoribosyl-ATP pyrophosphatase
      Short name=PRA-PH
    EC=3.6.1.31

Gene names

Name:	hisE
Ordered Locus Names:	Bcen2424_0433

Organism

Burkholderia cenocepacia (strain HI2424) [Complete proteome] [HAMAP]

Taxonomic identifier

331272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	121 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-ATP + H2O = 1-(5-phosphoribosyl)-AMP + diphosphate. HAMAP MF_01020
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9. HAMAP MF_01020
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the PRA-PH family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosyl-ATP diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 121	121	Phosphoribosyl-ATP pyrophosphatase HAMAP MF_01020		PRO_1000063325

Sequences

	Sequence		Length	Mass (Da)
	A0K3W0-1 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: BF4B1B529EEE26F8	FASTA	121	13,274
	10 20 30 40 50 60 MTQSTEDTLL RLAAVIDSRK GGDPDQSYVS RLFHKGDDAV LKKIGEEATE VVLAAKDVRQ 70 80 90 100 110 120 GGAPSALVGE VADLWFHCLV MLSHFDLSPA DVIAELERRE GLSGIEEKAL RKRREREENG G

References

[1]

"Complete sequence of chromosome 1 of Burkholderia cenocepacia HI2424." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., LiPuma J.J., Gonzalez C.F., Konstantinidis K., Tiedje J.M., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000458 Genomic DNA. Translation: ABK07187.1.
RefSeq	YP_834080.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4450076.
GenomeReviews	Gene locus Bcen2424_0433 in contig CP000458_GR.
KEGG	bch:Bcen2424_0433.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	A0K3W0.
OMA	A0K3W0. LSGHAEK.
Family and domain databases
HAMAP	MF_01020. [Tree]
InterPro	IPR008179. PRib-ATP_pyrophosphohydrolase. [Graphical view]
Pfam	PF01503. PRA-PH. 1 hit. [Graphical view]
ProDom	PD002611. Pra_PH/CH. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR03188. histidine_hisI. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HIS2_BURCH

Accession

Primary (citable) accession number: A0K3W0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	December 12, 2006
Last modified:	June 16, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)