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A0K3S0 (AROB_BURCH) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:Bcen2424_0393
OrganismBurkholderia cenocepacia (strain HI2424) [Complete proteome] [HAMAP]
Taxonomic identifier331272 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3593593-dehydroquinate synthase HAMAP MF_00110
PRO_1000094471

Sequences

Sequence LengthMass (Da)Tools
A0K3S0 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: D6E78637CDD1F046

FASTA35937,865
        10         20         30         40         50         60 
MITVNVDLGD RAYPIHIGAG LIGRTELFAP HIKGSSVTIV TNTTVDPLYG DALRAALAPL 

        70         80         90        100        110        120 
GKRVSTVVLP DGEAYKNWET LNLIFDGLLT DHADRKTTLV ALGGGVVGDM TGFAAACYMR 

       130        140        150        160        170        180 
GVPFIQVPTT LLSQVDSSVG GKTGINHPLG KNMIGAFYQP QAVIADIGAL TTLPDRELAA 

       190        200        210        220        230        240 
GVAEVIKTGA IADAGFFDWI EANVEALNRR EPAALAHAVK RSCEIKASVV AADEREGGLR 

       250        260        270        280        290        300 
AILNFGHTFG HAIEAGLGYG EWLHGEAVGC GMVMAGDLSV RLGLLDEASR QRLDAVIAAA 

       310        320        330        340        350 
HLPTRGPALG DARYMDLMRV DKKAEAGAIK FILLKRFGDT LITQAPDEAV FATLAQTTR

« Hide

References

[1]"Complete sequence of chromosome 1 of Burkholderia cenocepacia HI2424."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., LiPuma J.J., Gonzalez C.F., Konstantinidis K., Tiedje J.M., Richardson P.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HI2424.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000458 Genomic DNA. Translation: ABK07147.1.
RefSeqYP_834040.1. NC_008542.1.

3D structure databases

ProteinModelPortalA0K3S0.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0K3S0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4448115.
GenomeReviewsGene locus Bcen2424_0393 in contig CP000458_GR.
KEGGbch:Bcen2424_0393.
PATRIC19057972. VBIBurCen15205_0387.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0337.
HOGENOMHBG632303.
OMAVMALEMS.
ProtClustDBPRK00002.

Enzyme and pathway databases

BioCycBCEN331272:BCEN2424_0393-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_BURCH
AccessionPrimary (citable) accession number: A0K3S0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 12, 2006
Last modified: December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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